Fabien Beaufils

Affiliations

CHU Bordeaux, CRCM Pédiatrique, CIC 1401, Place Amélie Raba Léon, F-33000 Bordeaux, France.
Centre de Recherche Cardio-Thoracique de Bordeaux, INSERM, University Bordeaux, U1045, F-33000 Bordeaux, France.
Fédération Hospitalo-Universitaire FHU, ACRONIM, F-33000 Bordeaux, France.

Publications (21)

Preclinical Development of PQR514, a Highly Potent PI3K Inhibitor Bearing a Difluoromethyl-Pyrimidine Moiety.

ACS medicinal chemistry letters

Avec: Chiara Borsari , Denise Rageot , Florent Beaufils , Thomas Bohnacker , Erhan Keles , Ivan Buslov , Anna Melone , Alexander M Sele , Paul Hebeisen , Doriano Fabbro , Petra Hillmann , Matthias P Wymann

A Conformational Restriction Strategy for the Identification of a Highly Selective Pyrimido-pyrrolo-oxazine mTOR Inhibitor.

Journal of medicinal chemistry

Avec: Chiara Borsari , Denise Rageot , Alix Dall'Asen , Thomas Bohnacker , Anna Melone , Alexander M Sele , Eileen Jackson , Jean-Baptiste Langlois , Florent Beaufils , Paul Hebeisen , Doriano Fabbro , Petra Hillmann , Matthias P Wymann

Increased Fecal Calprotectin Is Associated with Worse Gastrointestinal Symptoms and Quality of Life Scores in Children with Cystic Fibrosis.

Journal of clinical medicine

Avec: Emmanuel Mas , Marie Mittaine , Martin Addra , Michael Fayon , Laurence Delhaes , Haude Clouzeau , François Galode , Thierry Lamireau , Stéphanie Bui , Raphaël Enaud

The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks.

Frontiers in cellular and infection microbiology

Avec: Raphaël Enaud , Renaud Prevel , Eleonora Ciarlo , Gregoire Wieërs , Benoit Guery , Laurence Delhaes

Rhinovirus infection of bronchial epithelium induces specific bronchial smooth muscle cell migration of severe asthmatic patients.

The Journal of allergy and clinical immunology

Avec: Alexis Celle , Pauline Esteves , Guillaume Cardouat , Edmée Eyraud , Isabelle Dupin , Elise Maurat , Sabrina Lacomme , Olga Ousova , Hugues Begueret , Matthieu Thumerel , Roger Marthan , Pierre-Olivier Girodet , Patrick Berger , Thomas Trian

Cellular and molecular mechanisms of NiONPs toxicity on eel hepatocytes HEPA-E1: An illustration of the impact of Ni release from mining activity in New Caledonia.

Chemosphere

Avec: Ophélie Germande , Guillemine Daffe , Patrice Gonzalez , Stéphane Mornet , Megi Bejko , Marie-Hélène Errera , Sabrina Lacomme , Etienne Gontier , Christelle Guibert , Isabelle Baudrimont , Magalie Baudrimont

Predicting exacerbations in severe preschool wheezers.

Pediatric pulmonology

Avec: Michael Fayon ,

4-(Difluoromethyl)-5-(4-((3

Journal of medicinal chemistry

Avec: Chiara Borsari , Erhan Keles , Denise Rageot , Andrea Treyer , Thomas Bohnacker , Lukas Bissegger , Martina De Pascale , Anna Melone , Rohitha Sriramaratnam , Florent Beaufils , Matthias Hamburger , Paul Hebeisen , Wolfgang Löscher , Doriano Fabbro , Petra Hillmann , Matthias P Wymann

The lower respiratory airway wall in children in health and disease.

ERJ open research

Avec: Michael Fayon ,

Adherence, reliability, and variability of home spirometry telemonitoring in cystic fibrosis.

Frontiers in pediatrics

Avec: Raphaël Enaud , François Gallode , Grégory Boucher , Julie Macey , Patrick Berger , Michael Fayon , Stéphanie Bui

Dietary intake assessment in children with cystic fibrosis using 3-day food diaries: a single-centre study.

Frontiers in pediatrics

Avec: Margaux Gaschignard , Pauline Gallet , Haude Clouzeau , Joris Menard , Aurélie Costanzo , Lucie Nouard , Laurence Delhaes , Candice Tetard , Thierry Lamireau , Michael Fayon , Stéphanie Bui , Raphaël Enaud

The Novel TORC1/2 Kinase Inhibitor PQR620 Has Anti-Tumor Activity in Lymphomas as a Single Agent and in Combination with Venetoclax.

Cancers

Avec: Chiara Tarantelli , Eugenio Gaudio , Petra Hillmann , Filippo Spriano , Giulio Sartori , Luca Aresu , Luciano Cascione , Denise Rageot , Ivo Kwee , Florent Beaufils , Emanuele Zucca , Anastasios Stathis , Matthias P Wymann , Vladimir Cmiljanovic , Doriano Fabbro , Francesco Bertoni

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Journal of medicinal chemistry

Avec: Denise Rageot , Thomas Bohnacker , Erhan Keles , Jacob A McPhail , Reece M Hoffmann , Anna Melone , Chiara Borsari , Rohitha Sriramaratnam , Alexander M Sele , Florent Beaufils , Paul Hebeisen , Doriano Fabbro , Petra Hillmann , John E Burke , Matthias P Wymann

Mitochondria are involved in bronchial smooth muscle remodeling in severe preschool wheezers.

The Journal of allergy and clinical immunology

Avec: Pauline Esteves , Raphaël Enaud , Ophélie Germande , Alexis Celle , Roger Marthan , Thomas Trian , Michael Fayon , Patrick Berger

Nutritional impact of CFTR modulators in children with cystic fibrosis.

Frontiers in pediatrics

Avec: Margaux Gaschignard , Florian Lussac-Sorton , Pauline Gallet , Haude Clouzeau , Joris Menard , Aurélie Costanzo , Lucie Nouard , Laurence Delhaes , Candice Tetard , Thierry Lamireau , Michael Fayon , Stéphanie Bui , Raphaël Enaud

Brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor reduce huntingtin levels in cell models of HD.

Neuropharmacology

Avec: Elisabeth Singer , Carolin Walter , Doriano Fabbro , Denise Rageot , Florent Beaufils , Matthias P Wymann , Nadine Rischert , Olaf Riess , Petra Hillmann , Huu Phuc Nguyen

Reduced Intestinal Inflammation With Lumacaftor/Ivacaftor in Adolescents With Cystic Fibrosis.

Journal of pediatric gastroenterology and nutrition

Avec: Candice Tétard , Marie Mittaine , Stéphanie Bui , Pascale Maumus , Michael Fayon , Pierre-Regis Burgel , Thierry Lamireau , Laurence Delhaes , Emmanuel Mas , Raphaël Enaud

NiONPs-induced alteration in calcium signaling and mitochondrial function in pulmonary artery endothelial cells involves oxidative stress and TRPV4 channels disruption.

Nanotoxicology

Avec: Ophélie Germande , Magalie Baudrimont , Véronique Freund-Michel , Thomas Ducret , Jean-François Quignard , Marie-Hélène Errera , Sabrina Lacomme , Etienne Gontier , Stéphane Mornet , Megi Bejko , Bernard Muller , Roger Marthan , Christelle Guibert , Juliette Deweirdt , Isabelle Baudrimont

Bronchial epithelia from adults and children: SARS-CoV-2 spread via syncytia formation and type III interferon infectivity restriction.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Guillaume Beucher , Marie-Lise Blondot , Alexis Celle , Noémie Pied , Patricia Recordon-Pinson , Pauline Esteves , Muriel Faure , Mathieu Métifiot , Sabrina Lacomme , Denis Dacheux , Derrick R Robinson , Gernot Längst , Marie-Edith Lafon , Patrick Berger , Marc Landry , Denis Malvy , Thomas Trian , Marie-Line Andreola , Harald Wodrich

Investigation of morpholine isosters for the development of a potent, selective and metabolically stable mTOR kinase inhibitor.

European journal of medicinal chemistry

Avec: Martina De Pascale , Lukas Bissegger , Chiara Tarantelli , Florent Beaufils , Alessandro Prescimone , Hayget Mohamed Seid Hedad , Omar Kayali , Clara Orbegozo , Luka Raguž , Thorsten Schaefer , Paul Hebeisen , Francesco Bertoni , Matthias P Wymann , Chiara Borsari

Home-spirometry exacerbation profiles in children with cystic fibrosis.

Pediatric pulmonology

Avec: Benoit Bouteleux , Michael Fayon , Stéphanie Bui

Réseau de co-auteurs

Michael Fayon 9 collaborations

Florent Beaufils 7 collaborations

Matthias P Wymann 7 collaborations

Raphaël Enaud 7 collaborations

Denise Rageot 6 collaborations

Doriano Fabbro 6 collaborations

Petra Hillmann 6 collaborations

Stéphanie Bui 6 collaborations

Chiara Borsari 5 collaborations

Paul Hebeisen 5 collaborations

Laurence Delhaes 5 collaborations

Thomas Bohnacker 4 collaborations

Anna Melone 4 collaborations

Thierry Lamireau 4 collaborations

Sabrina Lacomme 4 collaborations

Patrick Berger 4 collaborations

Erhan Keles 3 collaborations

Alexander M Sele 3 collaborations

Haude Clouzeau 3 collaborations

Alexis Celle 3 collaborations

Pauline Esteves 3 collaborations

Roger Marthan 3 collaborations

Thomas Trian 3 collaborations

Ophélie Germande 3 collaborations

Emmanuel Mas 2 collaborations

Marie Mittaine 2 collaborations

Stéphane Mornet 2 collaborations

Megi Bejko 2 collaborations

Marie-Hélène Errera 2 collaborations

Etienne Gontier 2 collaborations

Christelle Guibert 2 collaborations

Isabelle Baudrimont 2 collaborations

Magalie Baudrimont 2 collaborations

Lukas Bissegger 2 collaborations

Martina De Pascale 2 collaborations

Rohitha Sriramaratnam 2 collaborations

Margaux Gaschignard 2 collaborations

Pauline Gallet 2 collaborations

Joris Menard 2 collaborations

Aurélie Costanzo 2 collaborations

Lucie Nouard 2 collaborations

Candice Tetard 2 collaborations

Chiara Tarantelli 2 collaborations

Francesco Bertoni 2 collaborations

Ivan Buslov 1 collaboration

Alix Dall'Asen 1 collaboration

Eileen Jackson 1 collaboration

Jean-Baptiste Langlois 1 collaboration

Martin Addra 1 collaboration

François Galode 1 collaboration

Renaud Prevel 1 collaboration

Eleonora Ciarlo 1 collaboration

Gregoire Wieërs 1 collaboration

Benoit Guery 1 collaboration

Guillaume Cardouat 1 collaboration

Edmée Eyraud 1 collaboration

Isabelle Dupin 1 collaboration

Elise Maurat 1 collaboration

Olga Ousova 1 collaboration

Hugues Begueret 1 collaboration

Matthieu Thumerel 1 collaboration

Pierre-Olivier Girodet 1 collaboration

Guillemine Daffe 1 collaboration

Patrice Gonzalez 1 collaboration

Andrea Treyer 1 collaboration

Matthias Hamburger 1 collaboration

Wolfgang Löscher 1 collaboration

François Gallode 1 collaboration

Grégory Boucher 1 collaboration

Julie Macey 1 collaboration

Eugenio Gaudio 1 collaboration

Filippo Spriano 1 collaboration

Giulio Sartori 1 collaboration

Luca Aresu 1 collaboration

Luciano Cascione 1 collaboration

Ivo Kwee 1 collaboration

Emanuele Zucca 1 collaboration

Anastasios Stathis 1 collaboration

Vladimir Cmiljanovic 1 collaboration

Jacob A McPhail 1 collaboration

Reece M Hoffmann 1 collaboration

John E Burke 1 collaboration

Florian Lussac-Sorton 1 collaboration

Elisabeth Singer 1 collaboration

Carolin Walter 1 collaboration

Nadine Rischert 1 collaboration

Olaf Riess 1 collaboration

Huu Phuc Nguyen 1 collaboration

Candice Tétard 1 collaboration

Pascale Maumus 1 collaboration

Pierre-Regis Burgel 1 collaboration

Véronique Freund-Michel 1 collaboration

Thomas Ducret 1 collaboration

Jean-François Quignard 1 collaboration

Bernard Muller 1 collaboration

Juliette Deweirdt 1 collaboration

Guillaume Beucher 1 collaboration

Marie-Lise Blondot 1 collaboration

Noémie Pied 1 collaboration

Patricia Recordon-Pinson 1 collaboration

Muriel Faure 1 collaboration

Mathieu Métifiot 1 collaboration

Denis Dacheux 1 collaboration

Derrick R Robinson 1 collaboration

Gernot Längst 1 collaboration

Marie-Edith Lafon 1 collaboration

Marc Landry 1 collaboration

Denis Malvy 1 collaboration

Marie-Line Andreola 1 collaboration

Harald Wodrich 1 collaboration

Alessandro Prescimone 1 collaboration

Hayget Mohamed Seid Hedad 1 collaboration

Omar Kayali 1 collaboration

Clara Orbegozo 1 collaboration

Luka Raguž 1 collaboration

Thorsten Schaefer 1 collaboration

Benoit Bouteleux 1 collaboration