F Handle

Affiliations

Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Department of Urology, Division of Experimental Urology, Medical University of Innsbruck, Innsbruck, Austria.

Publications (19)

Inhibition of the sterol regulatory element binding protein (SREB-P) SREBF-1 overcomes docetaxel resistance in advanced prostate cancer.

The American journal of pathology

Avec: Maximilian Peter Brandt , Olesya Vakhrusheva , Hubert Hackl , Tamas Daher , Katrin Tagscherer , Wilfried Roth , Igor Tsaur , Florian Handle , Andrea Eigentler , Zoran Culig , Christian Thomas , Holger H H Erb , Axel Haferkamp , Eva Jüngel , Martin Puhr

Targeting the CLK2/SRSF9 splicing axis in prostate cancer leads to decreased ARV7 expression.

Molecular oncology

Avec: Jasper Van Goubergen , Miroslav Peřina , Florian Handle , Elisa Morales , Anika Kremer , Oliver Schmidt , Glen Kristiansen , Marcus V Cronauer , Frédéric R Santer

p300 is upregulated by docetaxel and is a target in chemoresistant prostate cancer.

Endocrine-related cancer

Avec: Martina Gruber , Lavinia Ferrone , Martin Puhr , Frédéric R Santer , Tobias Furlan , Iris E Eder , Natalie Sampson , Georg Schäfer , Florian Handle , Zoran Culig

The Oncogenic Protein Kinase/ATPase RIOK1 Is Up-Regulated via the c-myc/E2F Transcription Factor Axis in Prostate Cancer.

The American journal of pathology

Avec: Florian Handle , Martin Puhr , Martina Gruber , Chiara Andolfi , Georg Schäfer , Helmut Klocker , Johannes Haybaeck , Peter De Wulf , Zoran Culig

Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.

PloS one

Avec: Holger H H Erb , Julia Bodenbender , Florian Handle , Tamara Diehl , Lukas Donix , Igor Tsaur , Martin Gleave , Axel Haferkamp , Johannes Huber , Susanne Fuessel , Eva Juengel , Zoran Culig , Christian Thomas

Targeting the glucocorticoid receptor signature gene Mono Amine Oxidase-A enhances the efficacy of chemo- and anti-androgen therapy in advanced prostate cancer.

Oncogene

Avec: Martin Puhr , Andrea Eigentler , Florian Handle , Hubert Hackl , Christian Ploner , Isabel Heidegger , Georg Schaefer , Maximilian P Brandt , Julia Hoefer , Gabri Van der Pluijm , Helmut Klocker

MYC-Mediated Ribosomal Gene Expression Sensitizes Enzalutamide-resistant Prostate Cancer Cells to EP300/CREBBP Inhibitors.

The American journal of pathology

Avec: Tobias Furlan , Alexander Kirchmair , Natalie Sampson , Martin Puhr , Martina Gruber , Zlatko Trajanoski , Frédéric R Santer , Walther Parson , Florian Handle , Zoran Culig

A disease-associated missense mutation in CYP4F3 affects the metabolism of leukotriene B4 via disruption of electron transfer.

Journal of cachexia, sarcopenia and muscle

Avec: Elien Smeets , Shengyun Huang , Xiao Yin Lee , Erika Van Nieuwenhove , Christine Helsen , Florian Handle , Lisa Moris , Sarah El Kharraz , Roy Eerlings , Wout Devlies , Mathijs Willemsen , Leoni Bücken , Teresa Prezzemolo , Stephanie Humblet-Baron , Arnout Voet , Anne Rochtus , Ann Van Schepdael , Francis de Zegher , Frank Claessens

Preadipocytes in human granulation tissue: role in wound healing and response to macrophage polarization.

Inflammation and regeneration

Avec: Tina Rauchenwald , Florian Handle , Catherine E Connolly , Antonia Degen , Christof Seifarth , Martin Hermann , Christoph H Tripp , Doris Wilflingseder , Susanne Lobenwein , Dragana Savic , Leo Pölzl , Evi M Morandi , Dolores Wolfram , Ira-Ida Skvortsova , Patrizia Stoitzner , Johannes Haybaeck , Marko Konschake , Gerhard Pierer , Christian Ploner

Drivers of AR indifferent anti-androgen resistance in prostate cancer cells.

Scientific reports

Avec: Florian Handle , Stefan Prekovic , Christine Helsen , Thomas Van den Broeck , Elien Smeets , Lisa Moris , Roy Eerlings , Sarah El Kharraz , Alfonso Urbanucci , Ian G Mills , Steven Joniau , Gerhardt Attard , Frank Claessens

Antizyme Inhibitor 1 Regulates Matrikine Expression and Enhances the Metastatic Potential of Aggressive Primary Prostate Cancer.

Molecular cancer research : MCR

Avec: Thomas Van den Broeck , Lisa Moris , Thomas Gevaert , Elai Davicioni , Bram Boeckx , Diether Lambrechts , Christine Helsen , Florian Handle , Bart Ghesquière , Stefaan Soenen , Elien Smeets , Roy Eerlings , Sarah El Kharraz , Wout Devlies , R Jeffrey Karnes , Tamara Lotan , Hendrik Van Poppel , Steven Joniau , Frank Claessens

Small-molecule profiling for steroid receptor activity using a universal steroid receptor reporter assay.

The Journal of steroid biochemistry and molecular biology

Avec: Roy Eerlings , Nana Barbakadze , Tien Nguyen , Nanuli Nadaraia , Elien Smeets , Lisa Moris , Florian Handle , Sarah El Kharraz , Wout Devlies , Arnout Voet , Wim Dehaen , Frank Claessens , Christine Helsen

Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts.

Oncogene

Avec: Andrea Eigentler , Florian Handle , Silvia Schanung , Antonia Degen , Hubert Hackl , Holger H H Erb , Georgios Fotakis , Julia Hoefer , Christian Ploner , Karin Jöhrer , Isabel Heidegger , Andreas Pircher , Werner Klotz , Manfred Herold , Georg Schäfer , Zoran Culig , Martin Puhr

MED12 and CDK8/19 modulate androgen receptor activity and enzalutamide response in prostate cancer.

Endocrinology

Avec: Chiara Andolfi , Caterina Bartolini , Elisa Morales , Büşra Gündoğdu , Martin Puhr , Juan Guzman , Sven Wach , Helge Taubert , Achim Aigner , Iris E Eder , Florian Handle , Zoran Culig

Preclinical Models in Prostate Cancer: Resistance to AR Targeting Therapies in Prostate Cancer.

Cancers

Avec: Wout Devlies , Florian Handle , Gaëtan Devos , Steven Joniau , Frank Claessens

The stem cell inhibitor salinomycin decreases colony formation potential and tumor-initiating population in docetaxel-sensitive and docetaxel-resistant prostate cancer cells.

The Prostate

Avec: Martina Gruber , Florian Handle , Zoran Culig

Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse.

Nature communications

Avec: S Taavitsainen , N Engedal , S Cao , A Erickson , S Prekovic , D Wetterskog , T Tolonen , E M Vuorinen , A Kiviaho , R Nätkin , T Häkkinen , W Devlies , S Henttinen , R Kaarijärvi , M Lahnalampi , H Kaljunen , K Nowakowska , H Syvälä , M Bläuer , P Cremaschi , F Claessens , T Visakorpi , T L J Tammela , T Murtola , K J Granberg , A D Lamb , K Ketola , I G Mills , G Attard , W Wang , M Nykter , A Urbanucci

The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation.

EMBO reports

Avec: Sarah El Kharraz , Vanessa Dubois , Martin E van Royen , Adriaan B Houtsmuller , Ekatarina Pavlova , Nina Atanassova , Tien Nguyen , Arnout Voet , Roy Eerlings , Florian Handle , Stefan Prekovic , Elien Smeets , Lisa Moris , Wout Devlies , Claes Ohlsson , Matti Poutanen , Kevin J Verstrepen , Geert Carmeliet , Kaisa-Mari Launonen , Laura Helminen , Jorma J Palvimo , Claude Libert , Dirk Vanderschueren , Christine Helsen , Frank Claessens

Rational evolution for altering the ligand preference of estrogen receptor alpha.

Protein science : a publication of the Protein Society

Avec: Roy Eerlings , Purvi Gupta , Xiao Yin Lee , Tien Nguyen , Sarah El Kharraz , Florian Handle , Elien Smeets , Lisa Moris , Wout Devlies , Bram Vandewinkel , Irina Thiry , Duy Tien Ta , Anton Gorkovskiy , Karin Voordeckers , Els Henckaerts , Vitor B Pinheiro , Frank Claessens , Kevin J Verstrepen , Arnout Voet , Christine Helsen

Réseau de co-auteurs

Florian Handle 18 collaborations

Zoran Culig 8 collaborations

Martin Puhr 7 collaborations

Frank Claessens 7 collaborations

Elien Smeets 6 collaborations

Christine Helsen 6 collaborations

Lisa Moris 6 collaborations

Sarah El Kharraz 6 collaborations

Roy Eerlings 6 collaborations

Wout Devlies 6 collaborations

Martina Gruber 4 collaborations

Arnout Voet 4 collaborations

Hubert Hackl 3 collaborations

Andrea Eigentler 3 collaborations

Holger H H Erb 3 collaborations

Frédéric R Santer 3 collaborations

Georg Schäfer 3 collaborations

Christian Ploner 3 collaborations

Steven Joniau 3 collaborations

Tien Nguyen 3 collaborations

Igor Tsaur 2 collaborations

Christian Thomas 2 collaborations

Axel Haferkamp 2 collaborations

Elisa Morales 2 collaborations

Tobias Furlan 2 collaborations

Iris E Eder 2 collaborations

Natalie Sampson 2 collaborations

Chiara Andolfi 2 collaborations

Helmut Klocker 2 collaborations

Johannes Haybaeck 2 collaborations

Isabel Heidegger 2 collaborations

Julia Hoefer 2 collaborations

Xiao Yin Lee 2 collaborations

Antonia Degen 2 collaborations

Stefan Prekovic 2 collaborations

Thomas Van den Broeck 2 collaborations

Kevin J Verstrepen 2 collaborations

Maximilian Peter Brandt 1 collaboration

Olesya Vakhrusheva 1 collaboration

Tamas Daher 1 collaboration

Katrin Tagscherer 1 collaboration

Wilfried Roth 1 collaboration

Eva Jüngel 1 collaboration

Jasper Van Goubergen 1 collaboration

Miroslav Peřina 1 collaboration

Anika Kremer 1 collaboration

Oliver Schmidt 1 collaboration

Glen Kristiansen 1 collaboration

Marcus V Cronauer 1 collaboration

Lavinia Ferrone 1 collaboration

Peter De Wulf 1 collaboration

Julia Bodenbender 1 collaboration

Tamara Diehl 1 collaboration

Lukas Donix 1 collaboration

Martin Gleave 1 collaboration

Johannes Huber 1 collaboration

Susanne Fuessel 1 collaboration

Eva Juengel 1 collaboration

Georg Schaefer 1 collaboration

Maximilian P Brandt 1 collaboration

Gabri Van der Pluijm 1 collaboration

Alexander Kirchmair 1 collaboration

Zlatko Trajanoski 1 collaboration

Walther Parson 1 collaboration

Shengyun Huang 1 collaboration

Erika Van Nieuwenhove 1 collaboration

Mathijs Willemsen 1 collaboration

Leoni Bücken 1 collaboration

Teresa Prezzemolo 1 collaboration

Stephanie Humblet-Baron 1 collaboration

Anne Rochtus 1 collaboration

Ann Van Schepdael 1 collaboration

Francis de Zegher 1 collaboration

Tina Rauchenwald 1 collaboration

Catherine E Connolly 1 collaboration

Christof Seifarth 1 collaboration

Martin Hermann 1 collaboration

Christoph H Tripp 1 collaboration

Doris Wilflingseder 1 collaboration

Susanne Lobenwein 1 collaboration

Dragana Savic 1 collaboration

Leo Pölzl 1 collaboration

Evi M Morandi 1 collaboration

Dolores Wolfram 1 collaboration

Ira-Ida Skvortsova 1 collaboration

Patrizia Stoitzner 1 collaboration

Marko Konschake 1 collaboration

Gerhard Pierer 1 collaboration

Alfonso Urbanucci 1 collaboration

Ian G Mills 1 collaboration

Gerhardt Attard 1 collaboration

Thomas Gevaert 1 collaboration

Elai Davicioni 1 collaboration

Bram Boeckx 1 collaboration

Diether Lambrechts 1 collaboration

Bart Ghesquière 1 collaboration

Stefaan Soenen 1 collaboration

R Jeffrey Karnes 1 collaboration

Tamara Lotan 1 collaboration

Hendrik Van Poppel 1 collaboration

Nana Barbakadze 1 collaboration

Nanuli Nadaraia 1 collaboration

Wim Dehaen 1 collaboration

Silvia Schanung 1 collaboration

Georgios Fotakis 1 collaboration

Karin Jöhrer 1 collaboration

Andreas Pircher 1 collaboration

Werner Klotz 1 collaboration

Manfred Herold 1 collaboration

Caterina Bartolini 1 collaboration

Büşra Gündoğdu 1 collaboration

Juan Guzman 1 collaboration

Sven Wach 1 collaboration

Helge Taubert 1 collaboration

Achim Aigner 1 collaboration

Gaëtan Devos 1 collaboration

S Taavitsainen 1 collaboration

N Engedal 1 collaboration

S Cao 1 collaboration

A Erickson 1 collaboration

S Prekovic 1 collaboration

D Wetterskog 1 collaboration

T Tolonen 1 collaboration

E M Vuorinen 1 collaboration

A Kiviaho 1 collaboration

R Nätkin 1 collaboration

T Häkkinen 1 collaboration

W Devlies 1 collaboration

S Henttinen 1 collaboration

R Kaarijärvi 1 collaboration

M Lahnalampi 1 collaboration

H Kaljunen 1 collaboration

K Nowakowska 1 collaboration

H Syvälä 1 collaboration

M Bläuer 1 collaboration

P Cremaschi 1 collaboration

F Claessens 1 collaboration

T Visakorpi 1 collaboration

T L J Tammela 1 collaboration

T Murtola 1 collaboration

K J Granberg 1 collaboration

A D Lamb 1 collaboration

K Ketola 1 collaboration

I G Mills 1 collaboration

G Attard 1 collaboration

W Wang 1 collaboration

M Nykter 1 collaboration

A Urbanucci 1 collaboration

Vanessa Dubois 1 collaboration

Martin E van Royen 1 collaboration

Adriaan B Houtsmuller 1 collaboration

Ekatarina Pavlova 1 collaboration

Nina Atanassova 1 collaboration

Claes Ohlsson 1 collaboration

Matti Poutanen 1 collaboration

Geert Carmeliet 1 collaboration

Kaisa-Mari Launonen 1 collaboration

Laura Helminen 1 collaboration

Jorma J Palvimo 1 collaboration

Claude Libert 1 collaboration

Dirk Vanderschueren 1 collaboration

Purvi Gupta 1 collaboration

Bram Vandewinkel 1 collaboration

Irina Thiry 1 collaboration

Duy Tien Ta 1 collaboration

Anton Gorkovskiy 1 collaboration

Karin Voordeckers 1 collaboration

Els Henckaerts 1 collaboration

Vitor B Pinheiro 1 collaboration