Eric A Sobie

Affiliations

Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Publications (22)

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy.

Clinical pharmacology and therapeutics

Avec: Zhihua Li , Gary R Mirams , Takashi Yoshinaga , Bradley J Ridder , Xiaomei Han , Janell E Chen , Norman L Stockbridge , Todd A Wisialowski , Bruce Damiano , Stefano Severi , Pierre Morissette , Peter R Kowey , Mark Holbrook , Godfrey Smith , Randall L Rasmusson , Michael Liu , Zhen Song , Zhilin Qu , Derek J Leishman , Jill Steidl-Nichols , Blanca Rodriguez , Alfonso Bueno-Orovio , Xin Zhou , Elisa Passini , Andrew G Edwards , Stefano Morotti , Haibo Ni , Eleonora Grandi , Colleen E Clancy , Jamie Vandenberg , Adam Hill , Mikiko Nakamura , Thomas Singer , Liudmila Polonchuk , Andrea Greiter-Wilke , Ken Wang , Stephane Nave , Aaron Fullerton , Michelangelo Paci , Flora Musuamba Tshinanu , David G Strauss

Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity.

Nature communications

Avec: J G Coen van Hasselt , Rayees Rahman , Jens Hansen , Alan Stern , Jaehee V Shim , Yuguang Xiong , Amanda Pickard , Gomathi Jayaraman , Bin Hu , Milind Mahajan , James M Gallo , Joseph Goldfarb , Marc R Birtwistle , Avner Schlessinger , Evren U Azeloglu , Ravi Iyengar

Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.

Nature communications

Avec: Chrystian Junqueira Alves , Rafael Dariolli , Jonathan Haydak , Sangjo Kang , Theodore Hannah , Robert J Wiener , Stefanie DeFronzo , Rut Tejero , Gabriele L Gusella , Aarthi Ramakrishnan , Rodrigo Alves Dias , Alexandre Wojcinski , Santosh Kesari , Li Shen , José Paulo Rodrigues Furtado de Mendonça , Evren U Azeloglu , Hongyan Zou , Roland H Friedel

Creating cell-specific computational models of stem cell-derived cardiomyocytes using optical experiments.

PLoS computational biology

Avec: Janice Yang , Neil J Daily , Taylor K Pullinger , Tetsuro Wakatsuki ,

Investigational treatments for COVID-19 may increase ventricular arrhythmia risk through drug interactions.

medRxiv : the preprint server for health sciences

Avec: Meera Varshneya , Itziar Irurzun-Arana , Chiara Campana , Rafael Dariolli , Amy Gutierrez , Taylor K Pullinger ,

Prediction of arrhythmia susceptibility through mathematical modeling and machine learning.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Meera Varshneya , Xueyan Mei ,

Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity.

Scientific data

Avec: Yuguang Xiong , Tong Liu , Tong Chen , Jens Hansen , Bin Hu , Yibang Chen , Gomathi Jayaraman , Stephan Schürer , Dusica Vidovic , Joseph Goldfarb , Marc R Birtwistle , Ravi Iyengar , Hong Li , Evren U Azeloglu

Creating cell-specific computational models of stem cell-derived cardiomyocytes using optical experiments.

bioRxiv : the preprint server for biology

Avec: Janice Yang , Neil Daily , Taylor K Pullinger , Tetsuro Wakatsuki ,

Coupling and heterogeneity modulate pacemaking capability in healthy and diseased two-dimensional sinoatrial node tissue models.

PLoS computational biology

Avec: Chiara Campana , Eugenio Ricci , Chiara Bartolucci , Stefano Severi ,

Multiscale mapping of transcriptomic signatures for cardiotoxic drugs.

Nature communications

Avec: Jens Hansen , Yuguang Xiong , Mustafa M Siddiq , Priyanka Dhanan , Bin Hu , Bhavana Shewale , Arjun S Yadaw , Gomathi Jayaraman , Rosa E Tolentino , Yibang Chen , Pedro Martinez , Kristin G Beaumont , Robert Sebra , Dusica Vidovic , Stephan C Schürer , Joseph Goldfarb , James M Gallo , Marc R Birtwistle , Evren U Azeloglu , Seth I Berger , Angel Chan , Christoph Schaniel , Nicole C Dubois , Ravi Iyengar

Quantitative analysis of variability in an integrated model of human ventricular electrophysiology and β-adrenergic signaling.

Journal of molecular and cellular cardiology

Avec: Jingqi Q X Gong , Monica E Susilo , Anna Sher , Cynthia J Musante ,

Frontiers in physiology

Avec: Rafael Dariolli , Chiara Campana , Amy Gutierrez ,

Protein structure-based gene expression signatures.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Rayees Rahman , Nicole Zatorski , Jens Hansen , Yuguang Xiong , J G Coen van Hasselt , Marc R Birtwistle , Evren U Azeloglu , Ravi Iyengar , Avner Schlessinger

Cell-to-cell heterogeneity in ion channel conductance impacts substrate vulnerability to arrhythmia.

American journal of physiology. Heart and circulatory physiology

Avec: Taylor K Pullinger ,

A distinct molecular mechanism by which phenytoin rescues a novel long QT 3 variant.

Journal of molecular and cellular cardiology

Avec: Ivan Gando , Chiara Campana , Reina Bianca Tan , Frank Cecchin , William A Coetzee

A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals.

Stem cell reports

Avec: Christoph Schaniel , Priyanka Dhanan , Bin Hu , Yuguang Xiong , Teeya Raghunandan , David M Gonzalez , Rafael Dariolli , Sunita L D'Souza , Arjun S Yadaw , Jens Hansen , Gomathi Jayaraman , Bino Mathew , Moara Machado , Seth I Berger , Joseph Tripodi , Vesna Najfeld , Jalaj Garg , Marc Miller , Colleen S Surlyn , Katherine C Michelis , Neelima C Tangirala , Himali Weerahandi , David C Thomas , Kristin G Beaumont , Robert Sebra , Milind Mahajan , Eric Schadt , Dusica Vidovic , Stephan C Schürer , Joseph Goldfarb , Evren U Azeloglu , Marc R Birtwistle , Jason C Kovacic , Nicole C Dubois , Ravi Iyengar

The role of β-adrenergic system remodeling in human heart failure: A mechanistic investigation.

Journal of molecular and cellular cardiology

Avec: Maria T Mora , Jingqi Q X Gong , Beatriz Trenor

Circulation. Arrhythmia and electrophysiology

Avec: Nelson A Rodríguez , Nihir Patel , Rafael Dariolli , Simon Ng , Angelika G Aleman , Jingqi Q X Gong , Hung-Mo Lin , Matthew Rodríguez , Rebecca Josowitz , Katia Sol-Church , Karen W Gripp , Xianming Lin , Soomin C Song , Glenn I Fishman , Bruce D Gelb

Inflammation as a Risk Factor in Cardiotoxicity: An Important Consideration for Screening During Drug Development.

Frontiers in pharmacology

Avec: Chiara Campana , Rafael Dariolli , Mohamed Boutjdir ,

Investigational Treatments for COVID-19 may Increase Ventricular Arrhythmia Risk Through Drug Interactions.

CPT: pharmacometrics & systems pharmacology

Avec: Meera Varshneya , Itziar Irurzun-Arana , Chiara Campana , Rafael Dariolli , Amy Gutierrez , Taylor K Pullinger ,

PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes.

Cell stem cell

Avec: Nadeera M Wickramasinghe , David Sachs , Bhavana Shewale , David M Gonzalez , Priyanka Dhanan-Krishnan , Denis Torre , Elizabeth LaMarca , Serena Raimo , Rafael Dariolli , Madhavika N Serasinghe , Joshua Mayourian , Robert Sebra , Kristin Beaumont , Srinivas Iyengar , Deborah L French , Arne Hansen , Thomas Eschenhagen , Jerry E Chipuk , Adam Jacobs , Schahram Akbarian , Harry Ischiropoulos , Avi Ma'ayan , Sander M Houten , Kevin Costa , Nicole C Dubois

Time-regulated transcripts with the potential to modulate human pluripotent stem cell-derived cardiomyocyte differentiation.

Stem cell research & therapy

Avec: Juan J A M Muñoz , Rafael Dariolli , Caio Mateus da Silva , Elida A Neri , Iuri C Valadão , Lauro Thiago Turaça , Vanessa M Lima , Mariana Lombardi Peres de Carvalho , Mariliza R Velho , Jose E Krieger

Réseau de co-auteurs

Rafael Dariolli 9 collaborations

Evren U Azeloglu 6 collaborations

Chiara Campana 6 collaborations

Jens Hansen 5 collaborations

Yuguang Xiong 5 collaborations

Marc R Birtwistle 5 collaborations

Ravi Iyengar 5 collaborations

Taylor K Pullinger 5 collaborations

Gomathi Jayaraman 4 collaborations

Bin Hu 4 collaborations

Joseph Goldfarb 4 collaborations

Meera Varshneya 3 collaborations

Amy Gutierrez 3 collaborations

Dusica Vidovic 3 collaborations

Robert Sebra 3 collaborations

Nicole C Dubois 3 collaborations

Jingqi Q X Gong 3 collaborations

Stefano Severi 2 collaborations

J G Coen van Hasselt 2 collaborations

Rayees Rahman 2 collaborations

Milind Mahajan 2 collaborations

James M Gallo 2 collaborations

Avner Schlessinger 2 collaborations

Janice Yang 2 collaborations

Tetsuro Wakatsuki 2 collaborations

Itziar Irurzun-Arana 2 collaborations

Yibang Chen 2 collaborations

Priyanka Dhanan 2 collaborations

Bhavana Shewale 2 collaborations

Arjun S Yadaw 2 collaborations

Kristin G Beaumont 2 collaborations

Stephan C Schürer 2 collaborations

Seth I Berger 2 collaborations

Christoph Schaniel 2 collaborations

David M Gonzalez 2 collaborations

Zhihua Li 1 collaboration

Gary R Mirams 1 collaboration

Takashi Yoshinaga 1 collaboration

Bradley J Ridder 1 collaboration

Xiaomei Han 1 collaboration

Janell E Chen 1 collaboration

Norman L Stockbridge 1 collaboration

Todd A Wisialowski 1 collaboration

Bruce Damiano 1 collaboration

Pierre Morissette 1 collaboration

Peter R Kowey 1 collaboration

Mark Holbrook 1 collaboration

Godfrey Smith 1 collaboration

Randall L Rasmusson 1 collaboration

Michael Liu 1 collaboration

Zhen Song 1 collaboration

Zhilin Qu 1 collaboration

Derek J Leishman 1 collaboration

Jill Steidl-Nichols 1 collaboration

Blanca Rodriguez 1 collaboration

Alfonso Bueno-Orovio 1 collaboration

Xin Zhou 1 collaboration

Elisa Passini 1 collaboration

Andrew G Edwards 1 collaboration

Stefano Morotti 1 collaboration

Haibo Ni 1 collaboration

Eleonora Grandi 1 collaboration

Colleen E Clancy 1 collaboration

Jamie Vandenberg 1 collaboration

Adam Hill 1 collaboration

Mikiko Nakamura 1 collaboration

Thomas Singer 1 collaboration

Liudmila Polonchuk 1 collaboration

Andrea Greiter-Wilke 1 collaboration

Ken Wang 1 collaboration

Stephane Nave 1 collaboration

Aaron Fullerton 1 collaboration

Michelangelo Paci 1 collaboration

Flora Musuamba Tshinanu 1 collaboration

David G Strauss 1 collaboration

Alan Stern 1 collaboration

Jaehee V Shim 1 collaboration

Amanda Pickard 1 collaboration

Chrystian Junqueira Alves 1 collaboration

Jonathan Haydak 1 collaboration

Sangjo Kang 1 collaboration

Theodore Hannah 1 collaboration

Robert J Wiener 1 collaboration

Stefanie DeFronzo 1 collaboration

Rut Tejero 1 collaboration

Gabriele L Gusella 1 collaboration

Aarthi Ramakrishnan 1 collaboration

Rodrigo Alves Dias 1 collaboration

Alexandre Wojcinski 1 collaboration

Santosh Kesari 1 collaboration

Li Shen 1 collaboration

José Paulo Rodrigues Furtado de Mendonça 1 collaboration

Hongyan Zou 1 collaboration

Roland H Friedel 1 collaboration

Neil J Daily 1 collaboration

Xueyan Mei 1 collaboration

Tong Liu 1 collaboration

Tong Chen 1 collaboration

Stephan Schürer 1 collaboration

Hong Li 1 collaboration

Neil Daily 1 collaboration

Eugenio Ricci 1 collaboration

Chiara Bartolucci 1 collaboration

Mustafa M Siddiq 1 collaboration

Rosa E Tolentino 1 collaboration

Pedro Martinez 1 collaboration

Angel Chan 1 collaboration

Monica E Susilo 1 collaboration

Anna Sher 1 collaboration

Cynthia J Musante 1 collaboration

Nicole Zatorski 1 collaboration

Ivan Gando 1 collaboration

Reina Bianca Tan 1 collaboration

Frank Cecchin 1 collaboration

William A Coetzee 1 collaboration

Teeya Raghunandan 1 collaboration

Sunita L D'Souza 1 collaboration

Bino Mathew 1 collaboration

Moara Machado 1 collaboration

Joseph Tripodi 1 collaboration

Vesna Najfeld 1 collaboration

Jalaj Garg 1 collaboration

Marc Miller 1 collaboration

Colleen S Surlyn 1 collaboration

Katherine C Michelis 1 collaboration

Neelima C Tangirala 1 collaboration

Himali Weerahandi 1 collaboration

David C Thomas 1 collaboration

Eric Schadt 1 collaboration

Jason C Kovacic 1 collaboration

Maria T Mora 1 collaboration

Beatriz Trenor 1 collaboration

Nelson A Rodríguez 1 collaboration

Nihir Patel 1 collaboration

Simon Ng 1 collaboration

Angelika G Aleman 1 collaboration

Hung-Mo Lin 1 collaboration

Matthew Rodríguez 1 collaboration

Rebecca Josowitz 1 collaboration

Katia Sol-Church 1 collaboration

Karen W Gripp 1 collaboration

Xianming Lin 1 collaboration

Soomin C Song 1 collaboration

Glenn I Fishman 1 collaboration

Bruce D Gelb 1 collaboration

Mohamed Boutjdir 1 collaboration

Nadeera M Wickramasinghe 1 collaboration

David Sachs 1 collaboration

Priyanka Dhanan-Krishnan 1 collaboration

Denis Torre 1 collaboration

Elizabeth LaMarca 1 collaboration

Serena Raimo 1 collaboration

Madhavika N Serasinghe 1 collaboration

Joshua Mayourian 1 collaboration

Kristin Beaumont 1 collaboration

Srinivas Iyengar 1 collaboration

Deborah L French 1 collaboration

Arne Hansen 1 collaboration

Thomas Eschenhagen 1 collaboration

Jerry E Chipuk 1 collaboration

Adam Jacobs 1 collaboration

Schahram Akbarian 1 collaboration

Harry Ischiropoulos 1 collaboration

Avi Ma'ayan 1 collaboration

Sander M Houten 1 collaboration

Kevin Costa 1 collaboration

Juan J A M Muñoz 1 collaboration

Caio Mateus da Silva 1 collaboration

Elida A Neri 1 collaboration

Iuri C Valadão 1 collaboration

Lauro Thiago Turaça 1 collaboration

Vanessa M Lima 1 collaboration

Mariana Lombardi Peres de Carvalho 1 collaboration

Mariliza R Velho 1 collaboration

Jose E Krieger 1 collaboration