David W Morgens

Affiliations

Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA.

Publications (24)

Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway.

Cell reports

Avec: Michael M Dubreuil , Kanji Okumoto , Masanori Honsho , Kévin Contrepois , Brittany Lee-McMullen , Gavin McAllister Traber , Ria S Sood , Scott J Dixon , Michael P Snyder , Yukio Fujiki , Michael C Bassik

Targeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion.

Scientific reports

Avec: Laura M Prolo , Amy Li , Scott F Owen , Jonathon J Parker , Kara Foshay , Ryan T Nitta , Sara Bolin , Christy M Wilson , Johana C M Vega L , Emily J Luo , Gigi Nwagbo , Allen Waziri , Gordon Li , Richard J Reimer , Michael C Bassik , Gerald A Grant

High-throughput discovery and characterization of viral transcriptional effectors in human cells.

Cell systems

Avec: Connor H Ludwig , Abby R Thurm , Kevin J Yang , Josh Tycko , Michael C Bassik , Britt A Glaunsinger , Lacramioara Bintu

Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.

Nature neuroscience

Avec: Julia Marschallinger , Tal Iram , Macy Zardeneta , Song E Lee , Benoit Lehallier , Michael S Haney , John V Pluvinage , Vidhu Mathur , Oliver Hahn , Justin Kim , Julia Tevini , Thomas K Felder , Heimo Wolinski , Carolyn R Bertozzi , Michael C Bassik , Ludwig Aigner , Tony Wyss-Coray

Functional characterization of the PI3K/AKT/MTOR signaling pathway for targeted therapy in B-precursor acute lymphoblastic leukemia.

Cancer gene therapy

Avec: Patricia K Grüninger , Franziska Uhl , Heike Herzog , Gaia Gentile , Marta Andrade-Martinez , Tobias Schmidt , Kyuho Han , Michael C Bassik , Michael L Cleary , Oliver Gorka , Robert Zeiser , Olaf Groß , Jesús Duque-Afonso

Death-seq identifies regulators of cell death and senolytic therapies.

Cell metabolism

Avec: Alex Colville , Jie-Yu Liu , Cristina Rodriguez-Mateo , Samantha Thomas , Heather D Ishak , Ronghao Zhou , Julian D D Klein , Armon Goshayeshi , Jayesh S Salvi , David Yao , Kaitlyn Spees , Scott J Dixon , Chun Liu , June-Wha Rhee , Celine Lai , Joseph C Wu , Michael C Bassik , Thomas A Rando

CRISPR-Cas9 screens reveal regulators of ageing in neural stem cells.

Nature

Avec: Tyson J Ruetz , Angela N Pogson , Chloe M Kashiwagi , Stephanie D Gagnon , Bhek Morton , Eric D Sun , Jeeyoon Na , Robin W Yeo , Dena S Leeman , C Kimberly Tsui , Amy Li , Michael C Bassik , Anne Brunet

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.

Nature neuroscience

Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements.

Nature communications

Avec: Josh Tycko , Michael Wainberg , Georgi K Marinov , Oana Ursu , Gaelen T Hess , Braeden K Ego , Aradhana , Amy Li , Alisa Truong , Alexandro E Trevino , Kaitlyn Spees , David Yao , Irene M Kaplow , Peyton G Greenside , Douglas H Phanstiel , Michael P Snyder , Lacramioara Bintu , William J Greenleaf , Anshul Kundaje , Michael C Bassik

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains.

Nature

Avec: John V Pluvinage , Michael S Haney , Benjamin A H Smith , Jerry Sun , Tal Iram , Liana Bonanno , Lulin Li , Davis P Lee , Andrew C Yang , Steven R Shuken , David Gate , Madeleine Scott , Purvesh Khatri , Jian Luo , Carolyn R Bertozzi , Michael C Bassik , Tony Wyss-Coray

The N

Nature communications

Avec: Masanori Yoshinaga , Kyuho Han , Takuro Horii , Ryosuke Kobayashi , Tatsuaki Tsuruyama , Fabian Hia , Shota Yasukura , Asako Kajiya , Ting Cai , Pedro H C Cruz , Alexis Vandenbon , Yutaka Suzuki , Yukio Kawahara , Izuho Hatada , Michael C Bassik , Osamu Takeuchi

Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation.

Developmental cell

Avec: Melissa A Roberts , Kirandeep K Deol , Alyssa J Mathiowetz , Mike Lange , Dara E Leto , Julian Stevenson , Sayed Hadi Hashemi , Emilee Easter , Kartoosh Heydari , Mike A Nalls , Michael C Bassik , Martin Kampmann , Ron R Kopito , Faraz Faghri , James A Olzmann

Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.

Molecular cell

Avec: Kathryn T Bieging-Rolett , Alyssa M Kaiser , Anthony M Boutelle , Jose A Seoane , Eric L Van Nostrand , Changyu Zhu , Shauna L Houlihan , Stephano S Mello , Brian A Yee , Jacob McClendon , Sarah E Pierce , Ian P Winters , Mengxiong Wang , Andrew J Connolly , Scott W Lowe , Christina Curtis , Gene W Yeo , Monte M Winslow , Michael C Bassik , Laura D Attardi

Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins.

eLife

Avec: Charlene Chan , Andrew J Kane , Nicholas R Weir , Amy Li , Michael M Dubreuil , C Kimberly Tsui , Gaelen T Hess , Adam Lavertu , Kyuho Han , Nicole Polyakov , Jing Zhou , Emma L Handy , Philip Alabi , Amanda Dombroski , David Yao , Russ B Altman , Jason K Sello , Vladimir Denic , Michael C Bassik

CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation.

Neuron

Avec: Weiwei Cheng , Shaopeng Wang , Zhe Zhang , Lindsey R Hayes , Soojin Lee , Bede Portz , Yongzhi Xie , Baotram V Nguyen , Michael S Haney , Shirui Yan , Daoyuan Dong , Alyssa N Coyne , Junhua Yang , Fengfan Xian , Don W Cleveland , Zhaozhu Qiu , Jeffrey D Rothstein , James Shorter , Fen-Biao Gao , Michael C Bassik , Shuying Sun

Genome-wide synthetic lethal CRISPR screen identifies FIS1 as a genetic interactor of ALS-linked C9ORF72.

Brain research

Avec: Noori Chai , Michael S Haney , Julien Couthouis , Alyssa Benjamin , Kathryn Wu , James Ousey , Shirleen Fang , Sarah Finer , Michael C Bassik , Aaron D Gitler

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.

bioRxiv : the preprint server for biology

Avec: Alyssa J Mathiowetz , Emily S Meymand , Kirandeep K Deol , Güneş Parlakgül , Mike Lange , Stephany P Pang , Melissa A Roberts , Emily F Torres , Danielle M Jorgens , Reena Zalpuri , Misun Kang , Casadora Boone , Yaohuan Zhang , Emily Tso , Yingjiang Zhou , Saswata Talukdar , Tim P Levine , Gregory Ku , Ana Paula Arruda , James A Olzmann

Development of combination therapies with BTK inhibitors and dasatinib to treat CNS-infiltrating E2A-PBX1+/preBCR+ ALL.

Blood advances

Avec: Gaia Gentile , Teresa Poggio , Antonella Catalano , Minna Voutilainen , Mari Lahnalampi , Marta Andrade-Martinez , Tobias Ma , Roman Sankowski , Lina Goncharenko , Stefan Tholen , Kyuho Han , Marco Prinz , Michael Lübbert , Sophia Engel , Tanja N Hartmann , Gunnar Cario , Martin Schrappe , Lennart Lenk , Martin Stanulla , Justus Duyster , Peter Bronsert , Michael Bassik , Michael L Cleary , Oliver Schilling , Merja Heinäniemi , Jesus Duque-Afonso

Author Correction: Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.

Nature neuroscience

CRISPR-Cas9 screens identify regulators of antibody-drug conjugate toxicity.

Nature chemical biology

Avec: C Kimberly Tsui , Robyn M Barfield , Curt R Fischer , Amy Li , Benjamin A H Smith , Melissa Anne Gray , Carolyn R Bertozzi , David Rabuka , Michael C Bassik

Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation.

Molecular cell

Avec: Dara E Leto , Lichao Zhang , Christopher P Walczak , Joshua E Elias , Michael C Bassik , Ron R Kopito

A Two-tiered functional screen identifies herpesviral transcriptional modifiers and their essential domains.

PLoS pathogens

Avec: Divya Nandakumar , Allison L Didychuk , Kevin J Yang , Britt A Glaunsinger

Protocol for performing pooled CRISPR-Cas9 loss-of-function screens.

STAR protocols

Avec: Alyssa J Mathiowetz , Melissa A Roberts , James A Olzmann , Zhipeng Li

Coding and non-coding elements comprise a regulatory network controlling transcription in Kaposi's sarcoma-associated herpesvirus.

bioRxiv : the preprint server for biology

Avec: Leah Gulyas , Alejandro Rivera-Madera , Annabelle S Souza , Britt A Glaunsinger

Réseau de co-auteurs

Michael C Bassik 19 collaborations

Michael S Haney 6 collaborations

Amy Li 5 collaborations

Carolyn R Bertozzi 5 collaborations

Tal Iram 4 collaborations

John V Pluvinage 4 collaborations

Tony Wyss-Coray 4 collaborations

Kyuho Han 4 collaborations

Britt A Glaunsinger 3 collaborations

Julia Marschallinger 3 collaborations

Macy Zardeneta 3 collaborations

Song E Lee 3 collaborations

Benoit Lehallier 3 collaborations

Vidhu Mathur 3 collaborations

Oliver Hahn 3 collaborations

Justin Kim 3 collaborations

Julia Tevini 3 collaborations

Thomas K Felder 3 collaborations

Heimo Wolinski 3 collaborations

Ludwig Aigner 3 collaborations

David Yao 3 collaborations

C Kimberly Tsui 3 collaborations

Melissa A Roberts 3 collaborations

Alyssa J Mathiowetz 3 collaborations

James A Olzmann 3 collaborations

Michael M Dubreuil 2 collaborations

Scott J Dixon 2 collaborations

Michael P Snyder 2 collaborations

Kevin J Yang 2 collaborations

Josh Tycko 2 collaborations

Lacramioara Bintu 2 collaborations

Gaia Gentile 2 collaborations

Marta Andrade-Martinez 2 collaborations

Michael L Cleary 2 collaborations

Kaitlyn Spees 2 collaborations

Gaelen T Hess 2 collaborations

Benjamin A H Smith 2 collaborations

Kirandeep K Deol 2 collaborations

Mike Lange 2 collaborations

Dara E Leto 2 collaborations

Ron R Kopito 2 collaborations

Kanji Okumoto 1 collaboration

Masanori Honsho 1 collaboration

Kévin Contrepois 1 collaboration

Brittany Lee-McMullen 1 collaboration

Gavin McAllister Traber 1 collaboration

Ria S Sood 1 collaboration

Yukio Fujiki 1 collaboration

Laura M Prolo 1 collaboration

Scott F Owen 1 collaboration

Jonathon J Parker 1 collaboration

Kara Foshay 1 collaboration

Ryan T Nitta 1 collaboration

Sara Bolin 1 collaboration

Christy M Wilson 1 collaboration

Johana C M Vega L 1 collaboration

Emily J Luo 1 collaboration

Gigi Nwagbo 1 collaboration

Allen Waziri 1 collaboration

Gordon Li 1 collaboration

Richard J Reimer 1 collaboration

Gerald A Grant 1 collaboration

Connor H Ludwig 1 collaboration

Abby R Thurm 1 collaboration

Patricia K Grüninger 1 collaboration

Franziska Uhl 1 collaboration

Heike Herzog 1 collaboration

Tobias Schmidt 1 collaboration

Oliver Gorka 1 collaboration

Robert Zeiser 1 collaboration

Olaf Groß 1 collaboration

Jesús Duque-Afonso 1 collaboration

Alex Colville 1 collaboration

Jie-Yu Liu 1 collaboration

Cristina Rodriguez-Mateo 1 collaboration

Samantha Thomas 1 collaboration

Heather D Ishak 1 collaboration

Ronghao Zhou 1 collaboration

Julian D D Klein 1 collaboration

Armon Goshayeshi 1 collaboration

Jayesh S Salvi 1 collaboration

Chun Liu 1 collaboration

June-Wha Rhee 1 collaboration

Celine Lai 1 collaboration

Joseph C Wu 1 collaboration

Thomas A Rando 1 collaboration

Tyson J Ruetz 1 collaboration

Angela N Pogson 1 collaboration

Chloe M Kashiwagi 1 collaboration

Stephanie D Gagnon 1 collaboration

Bhek Morton 1 collaboration

Eric D Sun 1 collaboration

Jeeyoon Na 1 collaboration

Robin W Yeo 1 collaboration

Dena S Leeman 1 collaboration

Anne Brunet 1 collaboration

Michael Wainberg 1 collaboration

Georgi K Marinov 1 collaboration

Oana Ursu 1 collaboration

Braeden K Ego 1 collaboration

None Aradhana 1 collaboration

Alisa Truong 1 collaboration

Alexandro E Trevino 1 collaboration

Irene M Kaplow 1 collaboration

Peyton G Greenside 1 collaboration

Douglas H Phanstiel 1 collaboration

William J Greenleaf 1 collaboration

Anshul Kundaje 1 collaboration

Jerry Sun 1 collaboration

Liana Bonanno 1 collaboration

Lulin Li 1 collaboration

Davis P Lee 1 collaboration

Andrew C Yang 1 collaboration

Steven R Shuken 1 collaboration

David Gate 1 collaboration

Madeleine Scott 1 collaboration

Purvesh Khatri 1 collaboration

Jian Luo 1 collaboration

Masanori Yoshinaga 1 collaboration

Takuro Horii 1 collaboration

Ryosuke Kobayashi 1 collaboration

Tatsuaki Tsuruyama 1 collaboration

Fabian Hia 1 collaboration

Shota Yasukura 1 collaboration

Asako Kajiya 1 collaboration

Ting Cai 1 collaboration

Pedro H C Cruz 1 collaboration

Alexis Vandenbon 1 collaboration

Yutaka Suzuki 1 collaboration

Yukio Kawahara 1 collaboration

Izuho Hatada 1 collaboration

Osamu Takeuchi 1 collaboration

Julian Stevenson 1 collaboration

Sayed Hadi Hashemi 1 collaboration

Emilee Easter 1 collaboration

Kartoosh Heydari 1 collaboration

Mike A Nalls 1 collaboration

Martin Kampmann 1 collaboration

Faraz Faghri 1 collaboration

Kathryn T Bieging-Rolett 1 collaboration

Alyssa M Kaiser 1 collaboration

Anthony M Boutelle 1 collaboration

Jose A Seoane 1 collaboration

Eric L Van Nostrand 1 collaboration

Changyu Zhu 1 collaboration

Shauna L Houlihan 1 collaboration

Stephano S Mello 1 collaboration

Brian A Yee 1 collaboration

Jacob McClendon 1 collaboration

Sarah E Pierce 1 collaboration

Ian P Winters 1 collaboration

Mengxiong Wang 1 collaboration

Andrew J Connolly 1 collaboration

Scott W Lowe 1 collaboration

Christina Curtis 1 collaboration

Gene W Yeo 1 collaboration

Monte M Winslow 1 collaboration

Laura D Attardi 1 collaboration

Charlene Chan 1 collaboration

Andrew J Kane 1 collaboration

Nicholas R Weir 1 collaboration

Adam Lavertu 1 collaboration

Nicole Polyakov 1 collaboration

Jing Zhou 1 collaboration

Emma L Handy 1 collaboration

Philip Alabi 1 collaboration

Amanda Dombroski 1 collaboration

Russ B Altman 1 collaboration

Jason K Sello 1 collaboration

Vladimir Denic 1 collaboration

Weiwei Cheng 1 collaboration

Shaopeng Wang 1 collaboration

Zhe Zhang 1 collaboration

Lindsey R Hayes 1 collaboration

Soojin Lee 1 collaboration

Bede Portz 1 collaboration

Yongzhi Xie 1 collaboration

Baotram V Nguyen 1 collaboration

Shirui Yan 1 collaboration

Daoyuan Dong 1 collaboration

Alyssa N Coyne 1 collaboration

Junhua Yang 1 collaboration

Fengfan Xian 1 collaboration

Don W Cleveland 1 collaboration

Zhaozhu Qiu 1 collaboration

Jeffrey D Rothstein 1 collaboration

James Shorter 1 collaboration

Fen-Biao Gao 1 collaboration

Shuying Sun 1 collaboration

Noori Chai 1 collaboration

Julien Couthouis 1 collaboration

Alyssa Benjamin 1 collaboration

Kathryn Wu 1 collaboration

James Ousey 1 collaboration

Shirleen Fang 1 collaboration

Sarah Finer 1 collaboration

Aaron D Gitler 1 collaboration

Emily S Meymand 1 collaboration

Güneş Parlakgül 1 collaboration

Stephany P Pang 1 collaboration

Emily F Torres 1 collaboration

Danielle M Jorgens 1 collaboration

Reena Zalpuri 1 collaboration

Misun Kang 1 collaboration

Casadora Boone 1 collaboration

Yaohuan Zhang 1 collaboration

Emily Tso 1 collaboration

Yingjiang Zhou 1 collaboration

Saswata Talukdar 1 collaboration

Tim P Levine 1 collaboration

Gregory Ku 1 collaboration

Ana Paula Arruda 1 collaboration

Teresa Poggio 1 collaboration

Antonella Catalano 1 collaboration

Minna Voutilainen 1 collaboration

Mari Lahnalampi 1 collaboration

Tobias Ma 1 collaboration

Roman Sankowski 1 collaboration

Lina Goncharenko 1 collaboration

Stefan Tholen 1 collaboration

Marco Prinz 1 collaboration

Michael Lübbert 1 collaboration

Sophia Engel 1 collaboration

Tanja N Hartmann 1 collaboration

Gunnar Cario 1 collaboration

Martin Schrappe 1 collaboration

Lennart Lenk 1 collaboration

Martin Stanulla 1 collaboration

Justus Duyster 1 collaboration

Peter Bronsert 1 collaboration

Michael Bassik 1 collaboration

Oliver Schilling 1 collaboration

Merja Heinäniemi 1 collaboration

Jesus Duque-Afonso 1 collaboration

Robyn M Barfield 1 collaboration

Curt R Fischer 1 collaboration

Melissa Anne Gray 1 collaboration

David Rabuka 1 collaboration

Lichao Zhang 1 collaboration

Christopher P Walczak 1 collaboration

Joshua E Elias 1 collaboration

Divya Nandakumar 1 collaboration

Allison L Didychuk 1 collaboration

Zhipeng Li 1 collaboration

Leah Gulyas 1 collaboration

Alejandro Rivera-Madera 1 collaboration

Annabelle S Souza 1 collaboration