Charles J Eyermann

Affiliations

X-Chem Inc., 100 Beaver Street, Waltham, Massachusetts 02453, United States.

Publications (9)

Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening.

Journal of medicinal chemistry

Avec: Esther C Y Lee , Andrew J McRiner , Katy E Georgiadis , Julie Liu , Zooey Wang , Andrew D Ferguson , Benjamin Levin , Moritz von Rechenberg , Christopher D Hupp , Michael I Monteiro , Anthony D Keefe , Allison Olszewski , Paolo Centrella , Yanbin Liu , Shilpi Arora , John W Cuozzo , Ying Zhang , Matthew A Clark , Christelle Huguet , Anna Kohlmann

Antibacterial Spiropyrimidinetriones with N-Linked Azole Substituents on a Benzisoxazole Scaffold Targeting DNA Gyrase.

Journal of medicinal chemistry

Avec: Gregory S Basarab , Peter Doig , Vincent Galullo , Gunther Kern , Amy Kimzey , Amy Kutschke , Marshall Morningstar , Virna Schuck , Karthick Vishwanathan , Fei Zhou , Madhusudhan Gowravaram , Sheila Hauck

Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies.

Journal of medicinal chemistry

Avec: Candice Soares de Melo , Vinayak Singh , Alissa Myrick , Sandile B Simelane , Dale Taylor , Christel Brunschwig , Nina Lawrence , Dirk Schnappinger , Curtis A Engelhart , Anuradha Kumar , Tanya Parish , Qin Su , Timothy G Myers , Helena I M Boshoff , Clifton E Barry , Frederick A Sirgel , Paul D van Helden , Kirsteen I Buchanan , Tracy Bayliss , Simon R Green , Peter C Ray , Paul G Wyatt , Gregory S Basarab , Kelly Chibale , Sandeep R Ghorpade

High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.

Journal of medicinal chemistry

Avec: Hector Newman , Alen Krajnc , Dom Bellini , Grant A Boyle , Neil G Paterson , Katherine E McAuley , Robert Lesniak , Mukesh Gangar , Frank von Delft , Jürgen Brem , Kelly Chibale , Christopher J Schofield , Christopher G Dowson

Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity.

Journal of medicinal chemistry

Avec: Preshendren Govender , Rudolf Müller , Kawaljit Singh , Virsinha Reddy , Stephen Fienberg , Sandeep R Ghorpade , Lizbé Koekemoer , Alissa Myrick , Dirk Schnappinger , Curtis Engelhart , Jaclynn Meshanni , Jo Ann W Byl , Neil Osheroff , Vinayak Singh , Kelly Chibale , Gregory S Basarab

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.

Science (New York, N.Y.)

Avec: Melissa L Boby , Daren Fearon , Matteo Ferla , Mihajlo Filep , Lizbé Koekemoer , Matthew C Robinson , Auteur inconnu , John D Chodera , Alpha A Lee , Nir London , Annette von Delft , Frank von Delft , Hagit Achdout , Anthony Aimon , Dominic S Alonzi , Robert Arbon , Jasmin C Aschenbrenner , Blake H Balcomb , Elad Bar-David , Haim Barr , Amir Ben-Shmuel , James Bennett , Vitaliy A Bilenko , Bruce Borden , Pascale Boulet , Gregory R Bowman , Lennart Brewitz , Juliane Brun , Sarma Bvnbs , Mark Calmiano , Anna Carbery , Daniel W Carney , Emma Cattermole , Edcon Chang , Eugene Chernyshenko , Austin Clyde , Joseph E Coffland , Galit Cohen , Jason C Cole , Alessandro Contini , Lisa Cox , Tristan Ian Croll , Milan Cvitkovic , Steven De Jonghe , Alex Dias , Kim Donckers , David L Dotson , Alice Douangamath , Shirly Duberstein , Tim Dudgeon , Louise E Dunnett , Peter Eastman , Noam Erez , Michael Fairhead , Gwen Fate , Oleg Fedorov , Rafaela S Fernandes , Lori Ferrins , Richard Foster , Holly Foster , Laurent Fraisse , Ronen Gabizon , Adolfo García-Sastre , Victor O Gawriljuk , Paul Gehrtz , Carina Gileadi , Charline Giroud , William G Glass , Robert C Glen , Itai Glinert , Andre S Godoy , Marian Gorichko , Tyler Gorrie-Stone , Ed J Griffen , Amna Haneef , Storm Hassell Hart , Jag Heer , Michael Henry , Michelle Hill , Sam Horrell , Qiu Yu Judy Huang , Victor D Huliak , Matthew F D Hurley , Tomer Israely , Andrew Jajack , Jitske Jansen , Eric Jnoff , Dirk Jochmans , Tobias John , Benjamin Kaminow , Lulu Kang , Anastassia L Kantsadi , Peter W Kenny , J L Kiappes , Serhii O Kinakh , Boris Kovar , Tobias Krojer , Van Ngoc Thuy La , Sophie Laghnimi-Hahn , Bruce A Lefker , Haim Levy , Ryan M Lithgo , Ivan G Logvinenko , Petra Lukacik , Hannah Bruce Macdonald , Elizabeth M MacLean , Laetitia L Makower , Tika R Malla , Peter G Marples , Tatiana Matviiuk , Willam McCorkindale , Briana L McGovern , Sharon Melamed , Kostiantyn P Melnykov , Oleg Michurin , Pascal Miesen , Halina Mikolajek , Bruce F Milne , David Minh , Aaron Morris , Garrett M Morris , Melody Jane Morwitzer , Demetri Moustakas , Charles E Mowbray , Aline M Nakamura , Jose Brandao Neto , Johan Neyts , Luong Nguyen , Gabriela D Noske , Vladas Oleinikovas , Glaucius Oliva , Gijs J Overheul , C David Owen , Ruby Pai , Jin Pan , Nir Paran , Alexander Matthew Payne , Benjamin Perry , Maneesh Pingle , Jakir Pinjari , Boaz Politi , Ailsa Powell , Vladimír Pšenák , Iván Pulido , Reut Puni , Victor L Rangel , Rambabu N Reddi , Paul Rees , St Patrick Reid , Lauren Reid , Efrat Resnick , Emily Grace Ripka , Ralph P Robinson , Jaime Rodriguez-Guerra , Romel Rosales , Dominic A Rufa , Kadi Saar , Kumar Singh Saikatendu , Eidarus Salah , David Schaller , Jenke Scheen , Celia A Schiffer , Christopher J Schofield , Mikhail Shafeev , Aarif Shaikh , Ala M Shaqra , Jiye Shi , Khriesto Shurrush , Sukrit Singh , Assa Sittner , Peter Sjö , Rachael Skyner , Adam Smalley , Bart Smeets , Mihaela D Smilova , Leonardo J Solmesky , John Spencer , Claire Strain-Damerell , Vishwanath Swamy , Hadas Tamir , Jenny C Taylor , Rachael E Tennant , Warren Thompson , Andrew Thompson , Susana Tomásio , Charles W E Tomlinson , Igor S Tsurupa , Anthony Tumber , Ioannis Vakonakis , Ronald P van Rij , Laura Vangeel , Finny S Varghese , Mariana Vaschetto , Einat B Vitner , Vincent Voelz , Andrea Volkamer , Martin A Walsh , Walter Ward , Charlie Weatherall , Shay Weiss , Kris M White , Conor Francis Wild , Karolina D Witt , Matthew Wittmann , Nathan Wright , Yfat Yahalom-Ronen , Nese Kurt Yilmaz , Daniel Zaidmann , Ivy Zhang , Hadeer Zidane , Nicole Zitzmann , Sarah N Zvornicanin

Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure-Activity Relationship Studies, and Biological Assessment.

ACS omega

Avec: Rudolf Mueller , Virsinha Reddy , Aloysius T Nchinda , Fanuel Mebrahtu , Dale Taylor , Nina Lawrence , Lloyd Tanner , Marine Barnabe , Bin Zou , Ravinder R Kondreddi , Suresh B Lakshminarayana , Matthias Rottmann , Leslie J Street , Kelly Chibale

1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in

Journal of medicinal chemistry

Avec: Lutete Peguy Khonde , Rudolf Müller , Grant A Boyle , Virsinha Reddy , Aloysius T Nchinda , Stephen Fienberg , Vinayak Singh , Alissa Myrick , Efrem Abay , Mathew Njoroge , Nina Lawrence , Qin Su , Timothy G Myers , Helena I M Boshoff , Clifton E Barry , Frederick A Sirgel , Paul D van Helden , Lisa M Massoudi , Gregory T Robertson , Anne J Lenaerts , Gregory S Basarab , Sandeep R Ghorpade , Kelly Chibale

Probing the Requirements for Dual Angiotensin-Converting Enzyme C-Domain Selective/Neprilysin Inhibition.

Journal of medicinal chemistry

Avec: Lauren B Arendse , Gyles E Cozier , Gregory S Basarab , Sylva L Schwager , Kelly Chibale , K Ravi Acharya , Edward D Sturrock

Réseau de co-auteurs

Kelly Chibale 6 collaborations

Gregory S Basarab 5 collaborations

Vinayak Singh 3 collaborations

Alissa Myrick 3 collaborations

Nina Lawrence 3 collaborations

Sandeep R Ghorpade 3 collaborations

Virsinha Reddy 3 collaborations

Dale Taylor 2 collaborations

Dirk Schnappinger 2 collaborations

Qin Su 2 collaborations

Timothy G Myers 2 collaborations

Helena I M Boshoff 2 collaborations

Clifton E Barry 2 collaborations

Frederick A Sirgel 2 collaborations

Paul D van Helden 2 collaborations

Grant A Boyle 2 collaborations

Frank von Delft 2 collaborations

Christopher J Schofield 2 collaborations

Rudolf Müller 2 collaborations

Stephen Fienberg 2 collaborations

Lizbé Koekemoer 2 collaborations

Aloysius T Nchinda 2 collaborations

Esther C Y Lee 1 collaboration

Andrew J McRiner 1 collaboration

Katy E Georgiadis 1 collaboration

Julie Liu 1 collaboration

Zooey Wang 1 collaboration

Andrew D Ferguson 1 collaboration

Benjamin Levin 1 collaboration

Moritz von Rechenberg 1 collaboration

Christopher D Hupp 1 collaboration

Michael I Monteiro 1 collaboration

Anthony D Keefe 1 collaboration

Allison Olszewski 1 collaboration

Paolo Centrella 1 collaboration

Yanbin Liu 1 collaboration

Shilpi Arora 1 collaboration

John W Cuozzo 1 collaboration

Ying Zhang 1 collaboration

Matthew A Clark 1 collaboration

Christelle Huguet 1 collaboration

Anna Kohlmann 1 collaboration

Peter Doig 1 collaboration

Vincent Galullo 1 collaboration

Gunther Kern 1 collaboration

Amy Kimzey 1 collaboration

Amy Kutschke 1 collaboration

Marshall Morningstar 1 collaboration

Virna Schuck 1 collaboration

Karthick Vishwanathan 1 collaboration

Fei Zhou 1 collaboration

Madhusudhan Gowravaram 1 collaboration

Sheila Hauck 1 collaboration

Candice Soares de Melo 1 collaboration

Sandile B Simelane 1 collaboration

Christel Brunschwig 1 collaboration

Curtis A Engelhart 1 collaboration

Anuradha Kumar 1 collaboration

Tanya Parish 1 collaboration

Kirsteen I Buchanan 1 collaboration

Tracy Bayliss 1 collaboration

Simon R Green 1 collaboration

Peter C Ray 1 collaboration

Paul G Wyatt 1 collaboration

Hector Newman 1 collaboration

Alen Krajnc 1 collaboration

Dom Bellini 1 collaboration

Neil G Paterson 1 collaboration

Katherine E McAuley 1 collaboration

Robert Lesniak 1 collaboration

Mukesh Gangar 1 collaboration

Jürgen Brem 1 collaboration

Christopher G Dowson 1 collaboration

Preshendren Govender 1 collaboration

Kawaljit Singh 1 collaboration

Curtis Engelhart 1 collaboration

Jaclynn Meshanni 1 collaboration

Jo Ann W Byl 1 collaboration

Neil Osheroff 1 collaboration

Melissa L Boby 1 collaboration

Daren Fearon 1 collaboration

Matteo Ferla 1 collaboration

Mihajlo Filep 1 collaboration

Matthew C Robinson 1 collaboration

None None 1 collaboration

John D Chodera 1 collaboration

Alpha A Lee 1 collaboration

Nir London 1 collaboration

Annette von Delft 1 collaboration

Hagit Achdout 1 collaboration

Anthony Aimon 1 collaboration

Dominic S Alonzi 1 collaboration

Robert Arbon 1 collaboration

Jasmin C Aschenbrenner 1 collaboration

Blake H Balcomb 1 collaboration

Elad Bar-David 1 collaboration

Haim Barr 1 collaboration

Amir Ben-Shmuel 1 collaboration

James Bennett 1 collaboration

Vitaliy A Bilenko 1 collaboration

Bruce Borden 1 collaboration

Pascale Boulet 1 collaboration

Gregory R Bowman 1 collaboration

Lennart Brewitz 1 collaboration

Juliane Brun 1 collaboration

Sarma Bvnbs 1 collaboration

Mark Calmiano 1 collaboration

Anna Carbery 1 collaboration

Daniel W Carney 1 collaboration

Emma Cattermole 1 collaboration

Edcon Chang 1 collaboration

Eugene Chernyshenko 1 collaboration

Austin Clyde 1 collaboration

Joseph E Coffland 1 collaboration

Galit Cohen 1 collaboration

Jason C Cole 1 collaboration

Alessandro Contini 1 collaboration

Lisa Cox 1 collaboration

Tristan Ian Croll 1 collaboration

Milan Cvitkovic 1 collaboration

Steven De Jonghe 1 collaboration

Alex Dias 1 collaboration

Kim Donckers 1 collaboration

David L Dotson 1 collaboration

Alice Douangamath 1 collaboration

Shirly Duberstein 1 collaboration

Tim Dudgeon 1 collaboration

Louise E Dunnett 1 collaboration

Peter Eastman 1 collaboration

Noam Erez 1 collaboration

Michael Fairhead 1 collaboration

Gwen Fate 1 collaboration

Oleg Fedorov 1 collaboration

Rafaela S Fernandes 1 collaboration

Lori Ferrins 1 collaboration

Richard Foster 1 collaboration

Holly Foster 1 collaboration

Laurent Fraisse 1 collaboration

Ronen Gabizon 1 collaboration

Adolfo García-Sastre 1 collaboration

Victor O Gawriljuk 1 collaboration

Paul Gehrtz 1 collaboration

Carina Gileadi 1 collaboration

Charline Giroud 1 collaboration

William G Glass 1 collaboration

Robert C Glen 1 collaboration

Itai Glinert 1 collaboration

Andre S Godoy 1 collaboration

Marian Gorichko 1 collaboration

Tyler Gorrie-Stone 1 collaboration

Ed J Griffen 1 collaboration

Amna Haneef 1 collaboration

Storm Hassell Hart 1 collaboration

Jag Heer 1 collaboration

Michael Henry 1 collaboration

Michelle Hill 1 collaboration

Sam Horrell 1 collaboration

Qiu Yu Judy Huang 1 collaboration

Victor D Huliak 1 collaboration

Matthew F D Hurley 1 collaboration

Tomer Israely 1 collaboration

Andrew Jajack 1 collaboration

Jitske Jansen 1 collaboration

Eric Jnoff 1 collaboration

Dirk Jochmans 1 collaboration

Tobias John 1 collaboration

Benjamin Kaminow 1 collaboration

Lulu Kang 1 collaboration

Anastassia L Kantsadi 1 collaboration

Peter W Kenny 1 collaboration

J L Kiappes 1 collaboration

Serhii O Kinakh 1 collaboration

Boris Kovar 1 collaboration

Tobias Krojer 1 collaboration

Van Ngoc Thuy La 1 collaboration

Sophie Laghnimi-Hahn 1 collaboration

Bruce A Lefker 1 collaboration

Haim Levy 1 collaboration

Ryan M Lithgo 1 collaboration

Ivan G Logvinenko 1 collaboration

Petra Lukacik 1 collaboration

Hannah Bruce Macdonald 1 collaboration

Elizabeth M MacLean 1 collaboration

Laetitia L Makower 1 collaboration

Tika R Malla 1 collaboration

Peter G Marples 1 collaboration

Tatiana Matviiuk 1 collaboration

Willam McCorkindale 1 collaboration

Briana L McGovern 1 collaboration

Sharon Melamed 1 collaboration

Kostiantyn P Melnykov 1 collaboration

Oleg Michurin 1 collaboration

Pascal Miesen 1 collaboration

Halina Mikolajek 1 collaboration

Bruce F Milne 1 collaboration

David Minh 1 collaboration

Aaron Morris 1 collaboration

Garrett M Morris 1 collaboration

Melody Jane Morwitzer 1 collaboration

Demetri Moustakas 1 collaboration

Charles E Mowbray 1 collaboration

Aline M Nakamura 1 collaboration

Jose Brandao Neto 1 collaboration

Johan Neyts 1 collaboration

Luong Nguyen 1 collaboration

Gabriela D Noske 1 collaboration

Vladas Oleinikovas 1 collaboration

Glaucius Oliva 1 collaboration

Gijs J Overheul 1 collaboration

C David Owen 1 collaboration

Ruby Pai 1 collaboration

Jin Pan 1 collaboration

Nir Paran 1 collaboration

Alexander Matthew Payne 1 collaboration

Benjamin Perry 1 collaboration

Maneesh Pingle 1 collaboration

Jakir Pinjari 1 collaboration

Boaz Politi 1 collaboration

Ailsa Powell 1 collaboration

Vladimír Pšenák 1 collaboration

Iván Pulido 1 collaboration

Reut Puni 1 collaboration

Victor L Rangel 1 collaboration

Rambabu N Reddi 1 collaboration

Paul Rees 1 collaboration

St Patrick Reid 1 collaboration

Lauren Reid 1 collaboration

Efrat Resnick 1 collaboration

Emily Grace Ripka 1 collaboration

Ralph P Robinson 1 collaboration

Jaime Rodriguez-Guerra 1 collaboration

Romel Rosales 1 collaboration

Dominic A Rufa 1 collaboration

Kadi Saar 1 collaboration

Kumar Singh Saikatendu 1 collaboration

Eidarus Salah 1 collaboration

David Schaller 1 collaboration

Jenke Scheen 1 collaboration

Celia A Schiffer 1 collaboration

Mikhail Shafeev 1 collaboration

Aarif Shaikh 1 collaboration

Ala M Shaqra 1 collaboration

Jiye Shi 1 collaboration

Khriesto Shurrush 1 collaboration

Sukrit Singh 1 collaboration

Assa Sittner 1 collaboration

Peter Sjö 1 collaboration

Rachael Skyner 1 collaboration

Adam Smalley 1 collaboration

Bart Smeets 1 collaboration

Mihaela D Smilova 1 collaboration

Leonardo J Solmesky 1 collaboration

John Spencer 1 collaboration

Claire Strain-Damerell 1 collaboration

Vishwanath Swamy 1 collaboration

Hadas Tamir 1 collaboration

Jenny C Taylor 1 collaboration

Rachael E Tennant 1 collaboration

Warren Thompson 1 collaboration

Andrew Thompson 1 collaboration

Susana Tomásio 1 collaboration

Charles W E Tomlinson 1 collaboration

Igor S Tsurupa 1 collaboration

Anthony Tumber 1 collaboration

Ioannis Vakonakis 1 collaboration

Ronald P van Rij 1 collaboration

Laura Vangeel 1 collaboration

Finny S Varghese 1 collaboration

Mariana Vaschetto 1 collaboration

Einat B Vitner 1 collaboration

Vincent Voelz 1 collaboration

Andrea Volkamer 1 collaboration

Martin A Walsh 1 collaboration

Walter Ward 1 collaboration

Charlie Weatherall 1 collaboration

Shay Weiss 1 collaboration

Kris M White 1 collaboration

Conor Francis Wild 1 collaboration

Karolina D Witt 1 collaboration

Matthew Wittmann 1 collaboration

Nathan Wright 1 collaboration

Yfat Yahalom-Ronen 1 collaboration

Nese Kurt Yilmaz 1 collaboration

Daniel Zaidmann 1 collaboration

Ivy Zhang 1 collaboration

Hadeer Zidane 1 collaboration

Nicole Zitzmann 1 collaboration

Sarah N Zvornicanin 1 collaboration

Rudolf Mueller 1 collaboration

Fanuel Mebrahtu 1 collaboration

Lloyd Tanner 1 collaboration

Marine Barnabe 1 collaboration

Bin Zou 1 collaboration

Ravinder R Kondreddi 1 collaboration

Suresh B Lakshminarayana 1 collaboration

Matthias Rottmann 1 collaboration

Leslie J Street 1 collaboration

Lutete Peguy Khonde 1 collaboration

Efrem Abay 1 collaboration

Mathew Njoroge 1 collaboration

Lisa M Massoudi 1 collaboration

Gregory T Robertson 1 collaboration

Anne J Lenaerts 1 collaboration

Lauren B Arendse 1 collaboration

Gyles E Cozier 1 collaboration

Sylva L Schwager 1 collaboration

K Ravi Acharya 1 collaboration

Edward D Sturrock 1 collaboration