Laboratory of Applied Pharmacology, Institute of Drug Technology, Oswaldo Cruz Foundation, Rua Sizenando Nabuco 100, Manguinhos, Rio de Janeiro 21041-250, RJ, Brazil; Center for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. Avenida Brasil 4036, room 814, Manguinhos, Rio de Janeiro 21040-361, RJ, Brazil.