Alex J B Kreutzberger

Publications (21)

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the pre-hairpin intermediate of the spike protein.

bioRxiv : the preprint server for biology

Avec: Kailu Yang , Chuchu Wang , Ravi Ojha , Suvi Kuivanen , Sergio Couoh-Cardel , Serena Muratcioglu , Timothy J Eisen , K Ian White , Richard G Held , Subu Subramanian , Kendra Marcus , Richard A Pfuetzner , Luis Esquivies , Catherine A Doyle , John Kuriyan , Olli Vapalahti , Giuseppe Balistreri , Tomas Kirchhausen , Axel T Brunger

Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease.

Journal of virology

Avec: Anwesha Sanyal , Ravi Ojha , Jesse D Pyle , Olli Vapalahti , Giuseppe Balistreri , Tom Kirchhausen

SARS-CoV-2 requires acidic pH to infect cells.

bioRxiv : the preprint server for biology

Avec: Anwesha Sanyal , Anand Saminathan , Louis-Marie Bloyet , Spencer Stumpf , Zhuoming Liu , Ravi Ojha , Markku T Patjas , Ahmed Geneid , Gustavo Scanavachi , Catherine A Doyle , Elliott Somerville , Ricardo Bango Da Cunha Correira , Giuseppe Di Caprio , Sanna Toppila-Salmi , Antti Mäkitie , Volker Kiessling , Olli Vapalahti , Sean P J Whelan , Giuseppe Balistreri , Tom Kirchhausen

Complexin-1 and synaptotagmin-1 compete for binding sites on membranes containing PtdInsP

Biophysical journal

Avec: Qian Liang , Akosua P Ofosuhene , Volker Kiessling , Binyong Liang , Lukas K Tamm , David S Cafiso

SARS-CoV-2 requires acidic pH to infect cells.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Anwesha Sanyal , Anand Saminathan , Louis-Marie Bloyet , Spencer Stumpf , Zhuoming Liu , Ravi Ojha , Markku T Patjas , Ahmed Geneid , Gustavo Scanavachi , Catherine A Doyle , Elliott Somerville , Ricardo Bango Da Cunha Correia , Giuseppe Di Caprio , Sanna Toppila-Salmi , Antti Mäkitie , Volker Kiessling , Olli Vapalahti , Sean P J Whelan , Giuseppe Balistreri , Tom Kirchhausen

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein.

Proceedings of the National Academy of Sciences of the United States of America

Membrane lipids couple synaptotagmin to SNARE-mediated granule fusion in insulin-secreting cells.

Molecular biology of the cell

Avec: Chase Amos , Volker Kiessling , Noah A Schenk , Ramkumar Mohan , Sarah Nyenhuis , Catherine A Doyle , Hong-Yin Wang , Kandice Levental , Ilya Levental , Arun Anantharam , Lukas K Tamm

Endosomal fusion of pH-dependent enveloped viruses requires ion channel TRPM7.

Nature communications

Avec: Catherine A Doyle , Gregory W Busey , Wesley H Iobst , Volker Kiessling , Chloe Renken , Hansa Doppalapudi , Marta E Stremska , Mohan C Manjegowda , Mohd Arish , Weiming Wang , Shardul Naphade , Joel Kennedy , Louis-Marie Bloyet , Cassandra E Thompson , Paul W Rothlauf , Eric J Stipes , Sean P J Whelan , Lukas K Tamm , Jie Sun , Bimal N Desai

Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2.

eLife

Avec: Volker Kiessling , Catherine A Doyle , Noah Schenk , Clint M Upchurch , Margaret Elmer-Dixon , Amanda E Ward , Julia Preobraschenski , Syed S Hussein , Weronika Tomaka , Patrick Seelheim , Iman Kattan , Megan Harris , Binyong Liang , Anne K Kenworthy , Bimal N Desai , Norbert Leitinger , Arun Anantharam , J David Castle , Lukas K Tamm

Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry.

Nature structural & molecular biology

Avec: Jinwoo Lee , Laura Odongo , Elizabeth A Nelson , David A Nyenhuis , Volker Kiessling , Binyong Liang , David S Cafiso , Judith M White , Lukas K Tamm

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Ruochen Zang , James Brett Case , Eylan Yutuc , Xiucui Ma , Sheng Shen , Maria Florencia Gomez Castro , Zhuoming Liu , Qiru Zeng , Haiyan Zhao , Juhee Son , Paul W Rothlauf , Gaopeng Hou , Hu Zhang , Sayantan Bose , Xin Wang , Michael D Vahey , Kartik Mani , William J Griffiths , Tom Kirchhausen , Daved H Fremont , Haitao Guo , Abhinav Diwan , Yuqin Wang , Michael S Diamond , Sean P J Whelan , Siyuan Ding

Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Kailu Yang , Chuchu Wang , K Ian White , Richard A Pfuetzner , Luis Esquivies , Tomas Kirchhausen , Axel T Brunger

Inherited nuclear pore substructures template post-mitotic pore assembly.

Developmental cell

Avec: Yi-Ying Chou , Srigokul Upadhyayula , Justin Houser , Kangmin He , Wesley Skillern , Gustavo Scanavachi , Song Dang , Anwesha Sanyal , Kazuka G Ohashi , Giuseppe Di Caprio , Tegy John Vadakkan , Tom Kirchhausen

Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease.

bioRxiv : the preprint server for biology

Avec: Anwesha Sanyal , Ravi Ojha , Jesse D Pyle , Olli Vapalahti , Giuseppe Balistreri , Tom Kirchhausen

An antibody from single human V

Science immunology

Avec: Sai Luo , Jun Zhang , Amanda Eaton , Robert J Edwards , Changbin Jing , Hai-Qiang Dai , Gregory D Sempowski , Kenneth Cronin , Robert Parks , Adam Yongxin Ye , Katayoun Mansouri , Maggie Barr , Novalia Pishesha , Aimee Chapdelaine Williams , Lucas Vieira Francisco , Anand Saminathan , Hanqin Peng , Himanshu Batra , Lorenza Bellusci , Surender Khurana , S Munir Alam , David C Montefiori , Kevin O Saunders , Ming Tian , Hidde Ploegh , Tom Kirchhausen , Bing Chen , Barton F Haynes , Frederick W Alt

Drunken lipid membranes, not drunken SNARE proteins, promote fusion in a model of neurotransmitter release.

Frontiers in molecular neuroscience

Avec: Robert E Coffman , Katelyn N Kraichely , Volker Kiessling , Lukas K Tamm , Dixon J Woodbury

In vitro fusion of single synaptic and dense core vesicles reproduces key physiological properties.

Nature communications

Avec: Volker Kiessling , Christopher Stroupe , Binyong Liang , Julia Preobraschenski , Marcelo Ganzella , Mark A B Kreutzberger , Robert Nakamoto , Reinhard Jahn , J David Castle , Lukas K Tamm

Unraveling the mechanisms of calcium-dependent secretion.

The Journal of general physiology

Avec: Arun Anantharam ,

Rhomboid distorts lipids to break the viscosity-imposed speed limit of membrane diffusion.

Science (New York, N.Y.)

Avec: Ming Ji , Jesse Aaron , Ljubica Mihaljević , Siniša Urban

Synaptotagmin-7 enhances calcium-sensing of chromaffin cell granules and slows discharge of granule cargos.

Journal of neurochemistry

Avec: Mounir Bendahmane , Alina Morales , Noah A Schenk , Ramkumar Mohan , Shreeya Bakshi , Julie M Philippe , Shuang Zhang , Volker Kiessling , Lukas K Tamm , David R Giovannucci , Paul M Jenkins , Arun Anantharam

Conserved arginine residues in synaptotagmin 1 regulate fusion pore expansion through membrane contact.

Nature communications

Avec: Sarah B Nyenhuis , Nakul Karandikar , Volker Kiessling , Anusa Thapa , Binyong Liang , Lukas K Tamm , David S Cafiso

Réseau de co-auteurs

Volker Kiessling 11 collaborations

Lukas K Tamm 9 collaborations

Tom Kirchhausen 8 collaborations

Catherine A Doyle 7 collaborations

Ravi Ojha 6 collaborations

Olli Vapalahti 6 collaborations

Giuseppe Balistreri 6 collaborations

Anwesha Sanyal 5 collaborations

Binyong Liang 5 collaborations

Sean P J Whelan 4 collaborations

Arun Anantharam 4 collaborations

Kailu Yang 3 collaborations

Chuchu Wang 3 collaborations

K Ian White 3 collaborations

Richard A Pfuetzner 3 collaborations

Luis Esquivies 3 collaborations

Axel T Brunger 3 collaborations

Anand Saminathan 3 collaborations

Louis-Marie Bloyet 3 collaborations

Zhuoming Liu 3 collaborations

Gustavo Scanavachi 3 collaborations

Giuseppe Di Caprio 3 collaborations

David S Cafiso 3 collaborations

Suvi Kuivanen 2 collaborations

Sergio Couoh-Cardel 2 collaborations

Serena Muratcioglu 2 collaborations

Timothy J Eisen 2 collaborations

Richard G Held 2 collaborations

Subu Subramanian 2 collaborations

Kendra Marcus 2 collaborations

John Kuriyan 2 collaborations

Tomas Kirchhausen 2 collaborations

Jesse D Pyle 2 collaborations

Spencer Stumpf 2 collaborations

Markku T Patjas 2 collaborations

Ahmed Geneid 2 collaborations

Elliott Somerville 2 collaborations

Sanna Toppila-Salmi 2 collaborations

Antti Mäkitie 2 collaborations

Noah A Schenk 2 collaborations

Ramkumar Mohan 2 collaborations

Paul W Rothlauf 2 collaborations

Bimal N Desai 2 collaborations

Julia Preobraschenski 2 collaborations

J David Castle 2 collaborations

Ricardo Bango Da Cunha Correira 1 collaboration

Qian Liang 1 collaboration

Akosua P Ofosuhene 1 collaboration

Ricardo Bango Da Cunha Correia 1 collaboration

Chase Amos 1 collaboration

Sarah Nyenhuis 1 collaboration

Hong-Yin Wang 1 collaboration

Kandice Levental 1 collaboration

Ilya Levental 1 collaboration

Gregory W Busey 1 collaboration

Wesley H Iobst 1 collaboration

Chloe Renken 1 collaboration

Hansa Doppalapudi 1 collaboration

Marta E Stremska 1 collaboration

Mohan C Manjegowda 1 collaboration

Mohd Arish 1 collaboration

Weiming Wang 1 collaboration

Shardul Naphade 1 collaboration

Joel Kennedy 1 collaboration

Cassandra E Thompson 1 collaboration

Eric J Stipes 1 collaboration

Jie Sun 1 collaboration

Noah Schenk 1 collaboration

Clint M Upchurch 1 collaboration

Margaret Elmer-Dixon 1 collaboration

Amanda E Ward 1 collaboration

Syed S Hussein 1 collaboration

Weronika Tomaka 1 collaboration

Patrick Seelheim 1 collaboration

Iman Kattan 1 collaboration

Megan Harris 1 collaboration

Anne K Kenworthy 1 collaboration

Norbert Leitinger 1 collaboration

Jinwoo Lee 1 collaboration

Laura Odongo 1 collaboration

Elizabeth A Nelson 1 collaboration

David A Nyenhuis 1 collaboration

Judith M White 1 collaboration

Ruochen Zang 1 collaboration

James Brett Case 1 collaboration

Eylan Yutuc 1 collaboration

Xiucui Ma 1 collaboration

Sheng Shen 1 collaboration

Maria Florencia Gomez Castro 1 collaboration

Qiru Zeng 1 collaboration

Haiyan Zhao 1 collaboration

Juhee Son 1 collaboration

Gaopeng Hou 1 collaboration

Hu Zhang 1 collaboration

Sayantan Bose 1 collaboration

Xin Wang 1 collaboration

Michael D Vahey 1 collaboration

Kartik Mani 1 collaboration

William J Griffiths 1 collaboration

Daved H Fremont 1 collaboration

Haitao Guo 1 collaboration

Abhinav Diwan 1 collaboration

Yuqin Wang 1 collaboration

Michael S Diamond 1 collaboration

Siyuan Ding 1 collaboration

Yi-Ying Chou 1 collaboration

Srigokul Upadhyayula 1 collaboration

Justin Houser 1 collaboration

Kangmin He 1 collaboration

Wesley Skillern 1 collaboration

Song Dang 1 collaboration

Kazuka G Ohashi 1 collaboration

Tegy John Vadakkan 1 collaboration

Sai Luo 1 collaboration

Jun Zhang 1 collaboration

Amanda Eaton 1 collaboration

Robert J Edwards 1 collaboration

Changbin Jing 1 collaboration

Hai-Qiang Dai 1 collaboration

Gregory D Sempowski 1 collaboration

Kenneth Cronin 1 collaboration

Robert Parks 1 collaboration

Adam Yongxin Ye 1 collaboration

Katayoun Mansouri 1 collaboration

Maggie Barr 1 collaboration

Novalia Pishesha 1 collaboration

Aimee Chapdelaine Williams 1 collaboration

Lucas Vieira Francisco 1 collaboration

Hanqin Peng 1 collaboration

Himanshu Batra 1 collaboration

Lorenza Bellusci 1 collaboration

Surender Khurana 1 collaboration

S Munir Alam 1 collaboration

David C Montefiori 1 collaboration

Kevin O Saunders 1 collaboration

Ming Tian 1 collaboration

Hidde Ploegh 1 collaboration

Bing Chen 1 collaboration

Barton F Haynes 1 collaboration

Frederick W Alt 1 collaboration

Robert E Coffman 1 collaboration

Katelyn N Kraichely 1 collaboration

Dixon J Woodbury 1 collaboration

Christopher Stroupe 1 collaboration

Marcelo Ganzella 1 collaboration

Mark A B Kreutzberger 1 collaboration

Robert Nakamoto 1 collaboration

Reinhard Jahn 1 collaboration

Ming Ji 1 collaboration

Jesse Aaron 1 collaboration

Ljubica Mihaljević 1 collaboration

Siniša Urban 1 collaboration

Mounir Bendahmane 1 collaboration

Alina Morales 1 collaboration

Shreeya Bakshi 1 collaboration

Julie M Philippe 1 collaboration

Shuang Zhang 1 collaboration

David R Giovannucci 1 collaboration

Paul M Jenkins 1 collaboration

Sarah B Nyenhuis 1 collaboration

Nakul Karandikar 1 collaboration

Anusa Thapa 1 collaboration