Alan R Saltiel

Affiliations

Department of Medicine, University of California San Diego, La Jolla, CA 92093.

Publications (23)

YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Lirui Wang , Magdalena Mazagova , Chuyue Pan , Song Yang , Katharina Brandl , Jun Liu , Shannon M Reilly , Yanhan Wang , Zhaorui Miao , Rohit Loomba , Na Lu , Qinglong Guo , Jihua Liu , Ruth T Yu , Michael Downes , Ronald M Evans , David A Brenner , Bruce Beutler , Bernd Schnabl

FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition.

The Journal of clinical investigation

Avec: Shannon M Reilly , Mohammad Abu-Odeh , Magdalene Ameka , Julia H DeLuca , Meghan C Naber , Benyamin Dadpey , Nima Ebadat , Andrew V Gomez , Xiaoling Peng , BreAnne Poirier , Elyse Walk , Matthew J Potthoff ,

p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.

JCI insight

Avec: Vitor F Martins , Samuel A LaBarge , Alexandra Stanley , Kristoffer Svensson , Chao-Wei Hung , Omer Keinan , Theodore P Ciaraldi , Dion Banoian , Ji E Park , Christina Ha , Byron Hetrick , Gretchen A Meyer , Andrew Philp , Larry L David , Robert R Henry , Joseph E Aslan , Carrie E McCurdy , Simon Schenk

β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity.

The Journal of clinical investigation

Avec: Joseph M Valentine , Maryam Ahmadian , Omer Keinan , Mohammad Abu-Odeh , Peng Zhao , Xin Zhou , Mark P Keller , Hui Gao , Ruth T Yu , Christopher Liddle , Michael Downes , Jin Zhang , Aldons J Lusis , Alan D Attie , Ronald M Evans , Mikael Rydén ,

Neutralization of Oxidized Phospholipids Ameliorates Non-alcoholic Steatohepatitis.

Cell metabolism

Avec: Xiaoli Sun , Jason S Seidman , Peng Zhao , Ty D Troutman , Nathanael J Spann , Xuchu Que , Fangli Zhou , Zhongji Liao , Martina Pasillas , Xiaohong Yang , Jason A Magida , Tatiana Kisseleva , David A Brenner , Michael Downes , Ronald M Evans , Sotirios Tsimikas , Christopher K Glass , Joseph L Witztum

Science translational medicine

Avec: Jing Yong , Vishal S Parekh , Shannon M Reilly , Jonamani Nayak , Zhouji Chen , Cynthia Lebeaupin , Insook Jang , Jiangwei Zhang , Thazha P Prakash , Hong Sun , Sue Murray , Shuling Guo , Julio E Ayala , Leslie S Satin , Randal J Kaufman

Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation.

Nature metabolism

Avec: Wenmin Xia , Preethi Veeragandham , Yu Cao , Yayun Xu , Torrey E Rhyne , Jiaxin Qian , Chao-Wei Hung , Peng Zhao , Ying Jones , Hui Gao , Christopher Liddle , Ruth T Yu , Michael Downes , Ronald M Evans , Mikael Rydén , Martin Wabitsch , Zichen Wang , Hiroyuki Hakozaki , Johannes Schöneberg , Shannon M Reilly , Jianfeng Huang ,

Diet and feeding pattern modulate diurnal dynamics of the ileal microbiome and transcriptome.

Cell reports

Avec: Ana Carolina Dantas Machado , Steven D Brown , Amulya Lingaraju , Vignesh Sivaganesh , Cameron Martino , Amandine Chaix , Peng Zhao , Antonio F M Pinto , Max W Chang , R Alexander Richter , Alan Saghatelian , Rob Knight , Satchidananda Panda , Amir Zarrinpar

From overnutrition to liver injury: AMP-activated protein kinase in nonalcoholic fatty liver diseases.

The Journal of biological chemistry

Avec: Peng Zhao ,

Synthesis of deuterium-labelled amlexanox and its metabolic stability against mouse, rat, and human microsomes.

Journal of labelled compounds & radiopharmaceuticals

Avec: Xinmin Gan , Michael W Wilson , Tyler S Beyett , Bo Wen , Duxin Sun , Scott D Larsen , John J G Tesmer , Hollis D Showalter

Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes.

Nature

Avec: Omer Keinan , Joseph M Valentine , Haopeng Xiao , Sushil K Mahata , Shannon M Reilly , Mohammad Abu-Odeh , Julia H Deluca , Benyamin Dadpey , Leslie Cho , Austin Pan , Ruth T Yu , Yang Dai , Christopher Liddle , Michael Downes , Ronald M Evans , Aldons J Lusis , Markku Laakso , Edward T Chouchani , Mikael Rydén ,

TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation.

Cell metabolism

Avec: Jin Young Huh , Shannon M Reilly , Mohammad Abu-Odeh , Anne N Murphy , Sushil K Mahata , Jinyu Zhang , Yoori Cho , Jong Bae Seo , Chao-Wei Hung , Courtney R Green , Christian M Metallo ,

Interaction of Adipocyte Metabolic and Immune Functions Through TBK1.

Frontiers in immunology

Avec: Peng Zhao ,

FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes.

Cell reports

Avec: Mohammad Abu-Odeh , Yuan Zhang , Shannon M Reilly , Nima Ebadat , Omer Keinan , Joseph M Valentine , Maziar Hafezi-Bakhtiari , Hadeel Ashayer , Lana Mamoun , Xin Zhou , Jin Zhang , Ruth T Yu , Yang Dai , Christopher Liddle , Michael Downes , Ronald M Evans , Steven A Kliewer , David J Mangelsdorf ,

The TBK1/IKKε inhibitor amlexanox improves dyslipidemia and prevents atherosclerosis.

JCI insight

Avec: Peng Zhao , Xiaoli Sun , Zhongji Liao , Hong Yu , Dan Li , Zeyang Shen , Christopher K Glass , Joseph L Witztum ,

Bi-allelic Variants in RALGAPA1 Cause Profound Neurodevelopmental Disability, Muscular Hypotonia, Infantile Spasms, and Feeding Abnormalities.

American journal of human genetics

Avec: Matias Wagner , Yuliya Skorobogatko , Ben Pode-Shakked , Cynthia M Powell , Bader Alhaddad , Annette Seibt , Ortal Barel , Gali Heimer , Chen Hoffmann , Laurie A Demmer , Yezmin Perilla-Young , Marc Remke , Dagmar Wieczorek , Tharsini Navaratnarajah , Peter Lichtner , Dirk Klee , Hanan E Shamseldin , Fuad Al Mutairi , Ertan Mayatepek , Tim Strom , Thomas Meitinger , Fowzan S Alkuraya , Yair Anikster , Felix Distelmaier

Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3.

Nature metabolism

Avec: Shannon M Reilly , Chao-Wei Hung , Maryam Ahmadian , Peng Zhao , Omer Keinan , Andrew V Gomez , Julia H DeLuca , Benyamin Dadpey , Donald Lu , Jessica Zaid , BreAnne Poirier , Xiaoling Peng , Ruth T Yu , Michael Downes , Christopher Liddle , Ronald M Evans , Anne N Murphy ,

An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis.

Science (New York, N.Y.)

Avec: Peng Zhao , Xiaoli Sun , Cynthia Chaggan , Zhongji Liao , Kai In Wong , Feng He , Seema Singh , Rohit Loomba , Michael Karin , Joseph L Witztum ,

Roles of IκB kinases and TANK-binding kinase 1 in hepatic lipid metabolism and nonalcoholic fatty liver disease.

Experimental & molecular medicine

Avec: Jin Young Huh ,

Voices: Insulin and beyond.

Cell metabolism

Avec: Jesse Roth , Frances M Ashcroft , Claes B Wollheim , Timothy J Kieffer , Alan D Cherrington , Richard N Bergman , Roy Taylor , Sonia M Najjar , Oluf Pedersen , Helga Ellingsgaard , Jens Juul Holst , Michael A Nauck , Takashi Kadowaki , Michael P Czech , Silvia Corvera , Barbara E Corkey , Mark A Atkinson

Insulin signaling in health and disease.

The Journal of clinical investigation

Avec:

NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ.

Nature communications

Avec: Jianfeng Huang , Juan F Linares , Angeles Duran , Wenmin Xia , Timo D Müller , Maria T Diaz-Meco , Jorge Moscat

Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness.

Cell metabolism

Avec: Li Gu , Yahui Zhu , Kosuke Watari , Maiya Lee , Junlai Liu , Sofia Perez , Melinda Thai , Joshua E Mayfield , Bichen Zhang , Karina Cunha E Rocha , Fuming Li , Laura C Kim , Alexander C Jones , Igor H Wierzbicki , Xiao Liu , Alexandra C Newton , Tatiana Kisseleva , Jun Hee Lee , Wei Ying , David J Gonzalez , M Celeste Simon , Michael Karin

Réseau de co-auteurs

Peng Zhao 9 collaborations

Shannon M Reilly 8 collaborations

Michael Downes 7 collaborations

Ronald M Evans 7 collaborations

Ruth T Yu 6 collaborations

Mohammad Abu-Odeh 5 collaborations

Omer Keinan 5 collaborations

Christopher Liddle 5 collaborations

Chao-Wei Hung 4 collaborations

Benyamin Dadpey 3 collaborations

Joseph M Valentine 3 collaborations

Mikael Rydén 3 collaborations

Xiaoli Sun 3 collaborations

Zhongji Liao 3 collaborations

Joseph L Witztum 3 collaborations

Rohit Loomba 2 collaborations

David A Brenner 2 collaborations

Julia H DeLuca 2 collaborations

Nima Ebadat 2 collaborations

Andrew V Gomez 2 collaborations

Xiaoling Peng 2 collaborations

BreAnne Poirier 2 collaborations

Maryam Ahmadian 2 collaborations

Xin Zhou 2 collaborations

Hui Gao 2 collaborations

Jin Zhang 2 collaborations

Aldons J Lusis 2 collaborations

Tatiana Kisseleva 2 collaborations

Christopher K Glass 2 collaborations

Wenmin Xia 2 collaborations

Jianfeng Huang 2 collaborations

Sushil K Mahata 2 collaborations

Yang Dai 2 collaborations

Jin Young Huh 2 collaborations

Anne N Murphy 2 collaborations

Michael Karin 2 collaborations

Lirui Wang 1 collaboration

Magdalena Mazagova 1 collaboration

Chuyue Pan 1 collaboration

Song Yang 1 collaboration

Katharina Brandl 1 collaboration

Jun Liu 1 collaboration

Yanhan Wang 1 collaboration

Zhaorui Miao 1 collaboration

Na Lu 1 collaboration

Qinglong Guo 1 collaboration

Jihua Liu 1 collaboration

Bruce Beutler 1 collaboration

Bernd Schnabl 1 collaboration

Magdalene Ameka 1 collaboration

Meghan C Naber 1 collaboration

Elyse Walk 1 collaboration

Matthew J Potthoff 1 collaboration

Vitor F Martins 1 collaboration

Samuel A LaBarge 1 collaboration

Alexandra Stanley 1 collaboration

Kristoffer Svensson 1 collaboration

Theodore P Ciaraldi 1 collaboration

Dion Banoian 1 collaboration

Ji E Park 1 collaboration

Christina Ha 1 collaboration

Byron Hetrick 1 collaboration

Gretchen A Meyer 1 collaboration

Andrew Philp 1 collaboration

Larry L David 1 collaboration

Robert R Henry 1 collaboration

Joseph E Aslan 1 collaboration

Carrie E McCurdy 1 collaboration

Simon Schenk 1 collaboration

Mark P Keller 1 collaboration

Alan D Attie 1 collaboration

Jason S Seidman 1 collaboration

Ty D Troutman 1 collaboration

Nathanael J Spann 1 collaboration

Xuchu Que 1 collaboration

Fangli Zhou 1 collaboration

Martina Pasillas 1 collaboration

Xiaohong Yang 1 collaboration

Jason A Magida 1 collaboration

Sotirios Tsimikas 1 collaboration

Jing Yong 1 collaboration

Vishal S Parekh 1 collaboration

Jonamani Nayak 1 collaboration

Zhouji Chen 1 collaboration

Cynthia Lebeaupin 1 collaboration

Insook Jang 1 collaboration

Jiangwei Zhang 1 collaboration

Thazha P Prakash 1 collaboration

Hong Sun 1 collaboration

Sue Murray 1 collaboration

Shuling Guo 1 collaboration

Julio E Ayala 1 collaboration

Leslie S Satin 1 collaboration

Randal J Kaufman 1 collaboration

Preethi Veeragandham 1 collaboration

Yu Cao 1 collaboration

Yayun Xu 1 collaboration

Torrey E Rhyne 1 collaboration

Jiaxin Qian 1 collaboration

Ying Jones 1 collaboration

Martin Wabitsch 1 collaboration

Zichen Wang 1 collaboration

Hiroyuki Hakozaki 1 collaboration

Johannes Schöneberg 1 collaboration

Ana Carolina Dantas Machado 1 collaboration

Steven D Brown 1 collaboration

Amulya Lingaraju 1 collaboration

Vignesh Sivaganesh 1 collaboration

Cameron Martino 1 collaboration

Amandine Chaix 1 collaboration

Antonio F M Pinto 1 collaboration

Max W Chang 1 collaboration

R Alexander Richter 1 collaboration

Alan Saghatelian 1 collaboration

Rob Knight 1 collaboration

Satchidananda Panda 1 collaboration

Amir Zarrinpar 1 collaboration

Xinmin Gan 1 collaboration

Michael W Wilson 1 collaboration

Tyler S Beyett 1 collaboration

Bo Wen 1 collaboration

Duxin Sun 1 collaboration

Scott D Larsen 1 collaboration

John J G Tesmer 1 collaboration

Hollis D Showalter 1 collaboration

Haopeng Xiao 1 collaboration

Julia H Deluca 1 collaboration

Leslie Cho 1 collaboration

Austin Pan 1 collaboration

Markku Laakso 1 collaboration

Edward T Chouchani 1 collaboration

Jinyu Zhang 1 collaboration

Yoori Cho 1 collaboration

Jong Bae Seo 1 collaboration

Courtney R Green 1 collaboration

Christian M Metallo 1 collaboration

Yuan Zhang 1 collaboration

Maziar Hafezi-Bakhtiari 1 collaboration

Hadeel Ashayer 1 collaboration

Lana Mamoun 1 collaboration

Steven A Kliewer 1 collaboration

David J Mangelsdorf 1 collaboration

Hong Yu 1 collaboration

Dan Li 1 collaboration

Zeyang Shen 1 collaboration

Matias Wagner 1 collaboration

Yuliya Skorobogatko 1 collaboration

Ben Pode-Shakked 1 collaboration

Cynthia M Powell 1 collaboration

Bader Alhaddad 1 collaboration

Annette Seibt 1 collaboration

Ortal Barel 1 collaboration

Gali Heimer 1 collaboration

Chen Hoffmann 1 collaboration

Laurie A Demmer 1 collaboration

Yezmin Perilla-Young 1 collaboration

Marc Remke 1 collaboration

Dagmar Wieczorek 1 collaboration

Tharsini Navaratnarajah 1 collaboration

Peter Lichtner 1 collaboration

Dirk Klee 1 collaboration

Hanan E Shamseldin 1 collaboration

Fuad Al Mutairi 1 collaboration

Ertan Mayatepek 1 collaboration

Tim Strom 1 collaboration

Thomas Meitinger 1 collaboration

Fowzan S Alkuraya 1 collaboration

Yair Anikster 1 collaboration

Felix Distelmaier 1 collaboration

Donald Lu 1 collaboration

Jessica Zaid 1 collaboration

Cynthia Chaggan 1 collaboration

Kai In Wong 1 collaboration

Feng He 1 collaboration

Seema Singh 1 collaboration

Jesse Roth 1 collaboration

Frances M Ashcroft 1 collaboration

Claes B Wollheim 1 collaboration

Timothy J Kieffer 1 collaboration

Alan D Cherrington 1 collaboration

Richard N Bergman 1 collaboration

Roy Taylor 1 collaboration

Sonia M Najjar 1 collaboration

Oluf Pedersen 1 collaboration

Helga Ellingsgaard 1 collaboration

Jens Juul Holst 1 collaboration

Michael A Nauck 1 collaboration

Takashi Kadowaki 1 collaboration

Michael P Czech 1 collaboration

Silvia Corvera 1 collaboration

Barbara E Corkey 1 collaboration

Mark A Atkinson 1 collaboration

Juan F Linares 1 collaboration

Angeles Duran 1 collaboration

Timo D Müller 1 collaboration

Maria T Diaz-Meco 1 collaboration

Jorge Moscat 1 collaboration

Li Gu 1 collaboration

Yahui Zhu 1 collaboration

Kosuke Watari 1 collaboration

Maiya Lee 1 collaboration

Junlai Liu 1 collaboration

Sofia Perez 1 collaboration

Melinda Thai 1 collaboration

Joshua E Mayfield 1 collaboration

Bichen Zhang 1 collaboration

Karina Cunha E Rocha 1 collaboration

Fuming Li 1 collaboration

Laura C Kim 1 collaboration

Alexander C Jones 1 collaboration

Igor H Wierzbicki 1 collaboration

Xiao Liu 1 collaboration

Alexandra C Newton 1 collaboration

Jun Hee Lee 1 collaboration

Wei Ying 1 collaboration

David J Gonzalez 1 collaboration

M Celeste Simon 1 collaboration