Adam R Offenbacher

Affiliations

Department of Chemistry, East Carolina University, Greenville, North Carolina 27858, United States.

ORCID: 0000-0001-6990-7178

Publications (26)

Membrane-Mimicking Reverse Micelles for High-Resolution Interfacial Study of Proteins and Membranes.

Langmuir : the ACS journal of surfaces and colloids

Avec: Courtney L Labrecque , Aubree L Nolan , Angela M Develin , Abdul J Castillo , Brian Fuglestad

Development of Transient Recombinant Expression and Affinity Chromatography Systems for Human Fibrinogen.

International journal of molecular sciences

Avec: Grega Popovic , Nicholas C Kirby , Taylor C Dement , Kristine M Peterson , Caroline E Daub , Heather A Belcher , Martin Guthold , Nathan E Hudson

Temporal and spatial resolution of distal protein motions that activate hydrogen tunneling in soybean lipoxygenase.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Jan Paulo T Zaragoza , Shenshen Hu , Christine L Gee , Zachary M Firestein , Natalie Minnetian , Zhenyu Deng , Flora Fan , Anthony T Iavarone , Judith P Klinman

Impact of

Biochemistry

Avec: Chris Whittington , Ajay Sharma , S Gage Hill , Anthony T Iavarone , Brian M Hoffman ,

Mutagenesis, Hydrogen-Deuterium Exchange, and Molecular Docking Investigations Establish the Dimeric Interface of Human Platelet-Type 12-Lipoxygenase.

Biochemistry

Avec: Wan-Chen Tsai , Ansari Mukhtar Aleem , Chris Whittington , Wilian A Cortopassi , Chakrapani Kalyanaraman , Angel Baroz , Anthony T Iavarone , Ewa Skrzypczak-Jankun , Matthew P Jacobson , Theodore Holman

Detection of Catalytically Linked Conformational Changes in Wild-Type Class Ia Ribonucleotide Reductase Using Reaction-Induced FTIR Spectroscopy.

The journal of physical chemistry. B

Avec: Ryan Atlee Watson , Bridgette A Barry

Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder.

Archives of biochemistry and biophysics

Avec: Michelle Tran , Rachel L Signorelli , Adriana Yamaguchi , Eefie Chen , Michael Holinstat , Anthony T Iavarone , Theodore Holman

Identification of the Thermal Activation Network in Human 15-Lipoxygenase-2: Divergence from Plant Orthologs and Its Relationship to Hydrogen Tunneling Activation Barriers.

ACS catalysis

Avec: Amanda Ohler , Paris E Taylor , Jasmine A Bledsoe , Anthony T Iavarone , Nathaniel C Gilbert ,

A Proton Wire Mediates Proton Coupled Electron Transfer from Hydroxyurea and Other Hydroxamic Acids to Tyrosyl Radical in Class Ia Ribonucleotide Reductase.

The journal of physical chemistry. B

Avec: Bridgette A Barry

Impact of Local Electrostatics on the Redox Properties of Tryptophan Radicals in Azurin: Implications for Redox-Active Tryptophans in Proton-Coupled Electron Transfer.

The journal of physical chemistry letters

Avec: Kristin J Tyson , Amanda N Davis , Jessica L Norris , Libero J Bartolotti , Eli G Hvastkovs ,

Detecting and Characterizing the Kinetic Activation of Thermal Networks in Proteins: Thermal Transfer from a Distal, Solvent-Exposed Loop to the Active Site in Soybean Lipoxygenase.

The journal of physical chemistry. B

Avec: Jan Paulo T Zaragoza , Andy Nguy , Natalie Minnetian , Zhenyu Deng , Anthony T Iavarone , Judith P Klinman

Comparative kinetic isotope effects on first- and second-order rate constants of soybean lipoxygenase variants uncover a substrate-binding network.

The Journal of biological chemistry

Avec: Shenshen Hu , Edbert D Lu , Judith P Klinman

The journal of physical chemistry letters

Avec: Mohammad S Safiarian , R Atlee Watson , Raquel L Lieberman , Bridgette A Barry ,

Electrochemical and Structural Study of the Buried Tryptophan in Azurin: Effects of Hydration and Polarity on the Redox Potential of W48.

The journal of physical chemistry. B

Avec: Kristin Tyson , Chanin B Tangtartharakul , Matthias Zeug , Nathan Findling , Alice Haddy , Eli Hvastkovs , Jun-Yong Choe , Judy E Kim ,

Fatty Acid Allosteric Regulation of C-H Activation in Plant and Animal Lipoxygenases.

Molecules (Basel, Switzerland)

Avec: Theodore R Holman

The Soybean Lipoxygenase-Substrate Complex: Correlation between the Properties of Tunneling-Ready States and ENDOR-Detected Structures of Ground States.

Biochemistry

Avec: Ajay Sharma , Peter E Doan , Judith P Klinman , Brian M Hoffman

Kinetic Characterization of the C-H Activation Step for the Lipoxygenase from the Pathogenic Fungus

Biochemistry

Avec: Anastasiia Kostenko , Katherine Ray , Anthony T Iavarone ,

Biophysical Characterization of a Disabled Double Mutant of Soybean Lipoxygenase: The "Undoing" of Precise Substrate Positioning Relative to Metal Cofactor and an Identified Dynamical Network.

Journal of the American Chemical Society

Avec: Shenshen Hu , Erin M Thompson , Christine L Gee , Jarett Wilcoxen , Cody A M Carr , Daniil M Prigozhin , Vanessa Yang , Tom Alber , R David Britt , James S Fraser , Judith P Klinman

Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.

Bioorganic & medicinal chemistry

Avec: Wan-Chen Tsai , Nathan C Gilbert , Amanda Ohler , Michelle Armstrong , Steven Perry , Chakrapani Kalyanaraman , Adam Yasgar , Ganesha Rai , Anton Simeonov , Ajit Jadhav , Melissa Standley , Hsiau-Wei Lee , Phillip Crews , Anthony T Iavarone , Matthew P Jacobson , David B Neau , Marcia Newcomer , Theodore R Holman

Investigating membrane-binding properties of lipoxygenases using surface plasmon resonance.

Biochemical and biophysical research communications

Avec: Denise L Rohlik , Ethan Patel , Nathaniel C Gilbert , Brandon L Garcia

Systematic mapping of the conformational landscape and dynamism of soluble fibrinogen.

Journal of thrombosis and haemostasis : JTH

Avec: Jose E E Pinelo , Pragya Manandhar , Grega Popovic , Katherine Ray , Mehmet F Tasdelen , Quoc Nguyen , Anthony T Iavarone , Nathan E Hudson , Mehmet Sen

Synthesis of redox-active fluorinated 5-hydroxytryptophans as molecular reporters for biological electron transfer.

Chemical communications (Cambridge, England)

Avec: Amanda Ohler , Hanna Long , Kei Ohgo , Kristin Tyson , David Murray , Amanda Davis , Chris Whittington , Eli G Hvastkovs , Liam Duffy , Alice Haddy , Andrew L Sargent , William E Allen ,

Thermodynamic and biophysical study of fatty acid effector binding to soybean lipoxygenase: implications for allostery driven by helix α2 dynamics.

FEBS letters

Avec: Daniella E Roberts , Amy M Benton , Claire Fabian-Bayola , Anne M Spuches ,

Biochemistry

Avec: Ajay Sharma , Chris Whittington , Mohammed Jabed , S Gage Hill , Anastasiia Kostenko , Tao Yu , Pengfei Li , Peter E Doan , Brian M Hoffman ,

Effect of solvent viscosity on the activation barrier of hydrogen tunneling in the lipoxygenase reaction.

Archives of biochemistry and biophysics

Avec: Luis Guevara , Melissa Gouge , Amanda Ohler , S Gage Hill , Soham Patel ,

Substitution of the mononuclear, non-heme iron cofactor in lipoxygenases for structural studies.

Methods in enzymology

Avec: Andrew Jakobowski , S Gage Hill , S Wyatt Guy ,

Réseau de co-auteurs

Anthony T Iavarone 9 collaborations

Judith P Klinman 5 collaborations

Chris Whittington 4 collaborations

S Gage Hill 4 collaborations

Amanda Ohler 4 collaborations

Shenshen Hu 3 collaborations

Ajay Sharma 3 collaborations

Brian M Hoffman 3 collaborations

Bridgette A Barry 3 collaborations

Grega Popovic 2 collaborations

Nathan E Hudson 2 collaborations

Jan Paulo T Zaragoza 2 collaborations

Christine L Gee 2 collaborations

Natalie Minnetian 2 collaborations

Zhenyu Deng 2 collaborations

Wan-Chen Tsai 2 collaborations

Chakrapani Kalyanaraman 2 collaborations

Matthew P Jacobson 2 collaborations

Theodore Holman 2 collaborations

Nathaniel C Gilbert 2 collaborations

Eli G Hvastkovs 2 collaborations

Kristin Tyson 2 collaborations

Alice Haddy 2 collaborations

Theodore R Holman 2 collaborations

Peter E Doan 2 collaborations

Anastasiia Kostenko 2 collaborations

Katherine Ray 2 collaborations

Courtney L Labrecque 1 collaboration

Aubree L Nolan 1 collaboration

Angela M Develin 1 collaboration

Abdul J Castillo 1 collaboration

Brian Fuglestad 1 collaboration

Nicholas C Kirby 1 collaboration

Taylor C Dement 1 collaboration

Kristine M Peterson 1 collaboration

Caroline E Daub 1 collaboration

Heather A Belcher 1 collaboration

Martin Guthold 1 collaboration

Zachary M Firestein 1 collaboration

Flora Fan 1 collaboration

Ansari Mukhtar Aleem 1 collaboration

Wilian A Cortopassi 1 collaboration

Angel Baroz 1 collaboration

Ewa Skrzypczak-Jankun 1 collaboration

Ryan Atlee Watson 1 collaboration

Michelle Tran 1 collaboration

Rachel L Signorelli 1 collaboration

Adriana Yamaguchi 1 collaboration

Eefie Chen 1 collaboration

Michael Holinstat 1 collaboration

Paris E Taylor 1 collaboration

Jasmine A Bledsoe 1 collaboration

Kristin J Tyson 1 collaboration

Amanda N Davis 1 collaboration

Jessica L Norris 1 collaboration

Libero J Bartolotti 1 collaboration

Andy Nguy 1 collaboration

Edbert D Lu 1 collaboration

Mohammad S Safiarian 1 collaboration

R Atlee Watson 1 collaboration

Raquel L Lieberman 1 collaboration

Chanin B Tangtartharakul 1 collaboration

Matthias Zeug 1 collaboration

Nathan Findling 1 collaboration

Eli Hvastkovs 1 collaboration

Jun-Yong Choe 1 collaboration

Judy E Kim 1 collaboration

Erin M Thompson 1 collaboration

Jarett Wilcoxen 1 collaboration

Cody A M Carr 1 collaboration

Daniil M Prigozhin 1 collaboration

Vanessa Yang 1 collaboration

Tom Alber 1 collaboration

R David Britt 1 collaboration

James S Fraser 1 collaboration

Nathan C Gilbert 1 collaboration

Michelle Armstrong 1 collaboration

Steven Perry 1 collaboration

Adam Yasgar 1 collaboration

Ganesha Rai 1 collaboration

Anton Simeonov 1 collaboration

Ajit Jadhav 1 collaboration

Melissa Standley 1 collaboration

Hsiau-Wei Lee 1 collaboration

Phillip Crews 1 collaboration

David B Neau 1 collaboration

Marcia Newcomer 1 collaboration

Denise L Rohlik 1 collaboration

Ethan Patel 1 collaboration

Brandon L Garcia 1 collaboration

Jose E E Pinelo 1 collaboration

Pragya Manandhar 1 collaboration

Mehmet F Tasdelen 1 collaboration

Quoc Nguyen 1 collaboration

Mehmet Sen 1 collaboration

Hanna Long 1 collaboration

Kei Ohgo 1 collaboration

David Murray 1 collaboration

Amanda Davis 1 collaboration

Liam Duffy 1 collaboration

Andrew L Sargent 1 collaboration

William E Allen 1 collaboration

Daniella E Roberts 1 collaboration

Amy M Benton 1 collaboration

Claire Fabian-Bayola 1 collaboration

Anne M Spuches 1 collaboration

Mohammed Jabed 1 collaboration

Tao Yu 1 collaboration

Pengfei Li 1 collaboration

Luis Guevara 1 collaboration

Melissa Gouge 1 collaboration

Soham Patel 1 collaboration

Andrew Jakobowski 1 collaboration

S Wyatt Guy 1 collaboration