Younger epigenetic age is associated with higher cardiorespiratory fitness in individuals with airflow limitation.

Cardiovascular medicine Kinesiology Respiratory medicine

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
18 Oct 2024
Historique:
received: 19 02 2024
revised: 23 07 2024
accepted: 09 09 2024
medline: 11 10 2024
pubmed: 11 10 2024
entrez: 11 10 2024
Statut: epublish

Résumé

We hypothesized that increased cardiorespiratory fitness (CRF) slows down a person's aging, particularly in individuals with chronic airflow limitation (CAL). Participants aged ≥40 years (

Identifiants

DOI: 10.1016/j.isci.2024.110934 PMID: 39391738 PMC: PMC11465153
pubmed: 39391738
doi: 10.1016/j.isci.2024.110934
pii: S2589-0042(24)02159-X
pmc: PMC11465153
doi:

Types de publication

Journal Article

Langues

eng

Pagination

110934

Informations de copyright

© 2024 The Author(s).

Déclaration de conflit d'intérêts

The authors declare no competing interests.

Auteurs

Ana I Hernandez Cordero (AI)

Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, Canada.
Edwin S. H. Leong Healthy Aging Program, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

Carli Peters (C)

Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, Canada.

Xuan Li (X)

Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, Canada.

Chen Xi Yang (CX)

Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, Canada.

Amirthagowri Ambalavanan (A)

Department of Biomedical and Molecular Sciences, School of Medicine, and School of Computing, Queen's University, Kingston, Canada.

Julie L MacIsaac (JL)

Edwin S. H. Leong Healthy Aging Program, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.

Michael S Kobor (MS)

Edwin S. H. Leong Healthy Aging Program, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada.

Gregory J Fonseca (GJ)

McGill University Health Centre, McGill University, Montreal, Canada.

Dany Doiron (D)

McGill University Health Centre, McGill University, Montreal, Canada.

Wan Tan (W)

Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, Canada.

Jean Bourbeau (J)

McGill University Health Centre, McGill University, Montreal, Canada.

Dennis Jensen (D)

McGill University Health Centre, McGill University, Montreal, Canada.
Clinical Exercise & Respiratory Physiology Laboratory, Department of Kinesiology and Physical Education, Faculty of Education, McGill University, Montreal, Canada.

Don D Sin (DD)

Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, Canada.
Edwin S. H. Leong Healthy Aging Program, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, Canada.

Graeme J Koelwyn (GJ)

Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, Canada.
Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.

Michael K Stickland (MK)

Division of Pulmonary Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.

Qingling Duan (Q)

Department of Biomedical and Molecular Sciences, School of Medicine, and School of Computing, Queen's University, Kingston, Canada.

Janice M Leung (JM)

Centre for Heart Lung Innovation, St. Paul's Hospital and University of British Columbia, Vancouver, Canada.
Edwin S. H. Leong Healthy Aging Program, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

Classifications MeSH