Targeting Myeloid-Derived Suppressor Cells via Dual-Antibody Fluorescent Nanodiamond Conjugate.
MDSC
antibody conjugation
fluorescent nanodiamonds
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
17 Sep 2024
17 Sep 2024
Historique:
received:
29
07
2024
revised:
10
09
2024
accepted:
12
09
2024
medline:
27
9
2024
pubmed:
27
9
2024
entrez:
27
9
2024
Statut:
epublish
Résumé
Fluorescent nanodiamonds (FNDs) are carbon-based nanomaterials that emit bright, photostable fluorescence and exhibit a modifiable surface chemistry. Myeloid-derived suppressor cells (MDSCs) are an immunosuppressive cell population known to expand in cancer patients and contribute to worse patient outcomes. To target MDSC, glycidol-coated FND were conjugated with antibodies against the murine MDSC markers, CD11b and GR1 (dual-Ab FND). In vitro, dual-Ab FND uptake by murine MDSC was significantly higher than IgG-coated FND (94.7% vs. 69.0%,
Identifiants
pubmed: 39330666
pii: nano14181509
doi: 10.3390/nano14181509
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIH HHS
ID : P01 CA95426
Pays : United States
Organisme : NIH HHS
ID : P30 CA016058
Pays : United States
Organisme : NIH HHS
ID : T32 5T32CA090223
Pays : United States
Organisme : NIH HHS
ID : UM1 CA186712
Pays : United States
Organisme : NCI NIH HHS
ID : 75N91019C00014
Pays : United States
Organisme : NIH HHS
ID : HHSN268201300031C
Pays : United States