Multidimensional profiling of human T cells reveals high CD38 expression, marking recent thymic emigrants and age-related naive T cell remodeling.

PBMC aging human naive T cells recent thymic emigrants

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
17 Sep 2024
Historique:
received: 26 01 2024
revised: 21 06 2024
accepted: 28 08 2024
medline: 26 9 2024
pubmed: 26 9 2024
entrez: 25 9 2024
Statut: aheadofprint

Résumé

Thymic involution is a key factor in human immune aging, leading to reduced thymic output and a decline in recent thymic emigrant (RTE) naive T cells in circulation. Currently, the precise definition of human RTEs and their corresponding cell surface markers lacks clarity. Analysis of single-cell RNA-seq/ATAC-seq data distinguished RTEs by the expression of SOX4, IKZF2, and TOX and CD38 protein, whereby surface CD38

Identifiants

DOI: 10.1016/j.immuni.2024.08.019 PMID: 39321807
pubmed: 39321807
pii: S1074-7613(24)00418-7
doi: 10.1016/j.immuni.2024.08.019
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Pavla Bohacova (P)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Marina Terekhova (M)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Petr Tsurinov (P)

JetBrains Research, Paphos 8021, Cyprus.

Riley Mullins (R)

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.

Kamila Husarcikova (K)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Irina Shchukina (I)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Alina Ulezko Antonova (AU)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Barbora Echalar (B)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Jan Kossl (J)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Adam Saidu (A)

Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Thomas Francis (T)

Centre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London SE1 1UL, UK.

Chelsea Mannie (C)

Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

Laura Arthur (L)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Stephen D R Harridge (SDR)

Centre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London SE1 1UL, UK.

Daniel Kreisel (D)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

Philip A Mudd (PA)

Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO 63110, USA.

Angela M Taylor (AM)

Department of Medicine, Cardiovascular Division, University of Virginia, Charlottesville, VA 22903, USA.

Coleen A McNamara (CA)

Department of Medicine, Cardiovascular Division, University of Virginia, Charlottesville, VA 22903, USA; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22903, USA.

Marina Cella (M)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Sidharth V Puram (SV)

Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA; Rob Ebert and Greg Stubblefield Head and Neck Tumor Center at Siteman Cancer Center, St. Louis, MO 63110, USA.

Theo van den Broek (T)

Center for Translational Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht 3584CX, the Netherlands.

Femke van Wijk (F)

Center for Translational Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht 3584CX, the Netherlands.

Pirooz Eghtesady (P)

Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

Maxim N Artyomov (MN)

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: martyomov@wustl.edu.

Classifications MeSH