Immunotherapy for ovarian cancer: towards a tailored immunophenotype-based approach.


Journal

Nature reviews. Clinical oncology
ISSN: 1759-4782
Titre abrégé: Nat Rev Clin Oncol
Pays: England
ID NLM: 101500077

Informations de publication

Date de publication:
04 Sep 2024
Historique:
accepted: 12 08 2024
medline: 5 9 2024
pubmed: 5 9 2024
entrez: 4 9 2024
Statut: aheadofprint

Résumé

Despite documented evidence that ovarian cancer cells express immune-checkpoint molecules, such as PD-1 and PD-L1, and of a positive correlation between the presence of tumour-infiltrating lymphocytes and favourable overall survival outcomes in patients with this tumour type, the results of trials testing immune-checkpoint inhibitors (ICIs) in these patients thus far have been disappointing. The lack of response to ICIs can be attributed to tumour heterogeneity as well as inherent or acquired resistance associated with the tumour microenvironment (TME). Understanding tumour immunobiology, discovering biomarkers for patient selection and establishing optimal treatment combinations remains the hope but also a key challenge for the future application of immunotherapy in ovarian cancer. In this Review, we summarize results from trials testing ICIs in patients with ovarian cancer. We propose the implementation of a systematic CD8

Identifiants

pubmed: 39232212
doi: 10.1038/s41571-024-00937-4
pii: 10.1038/s41571-024-00937-4
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. Springer Nature Limited.

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Auteurs

Eleonora Ghisoni (E)

Department of Oncology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.
Agora Cancer Research Center, Lausanne, Switzerland.

Matteo Morotti (M)

Department of Oncology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.
Agora Cancer Research Center, Lausanne, Switzerland.

Apostolos Sarivalasis (A)

Department of Oncology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

Alizée J Grimm (AJ)

Department of Oncology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.
Agora Cancer Research Center, Lausanne, Switzerland.

Lana Kandalaft (L)

Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.
Center of Experimental Therapeutics, Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland.

Denarda Dangaj Laniti (DD)

Department of Oncology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland.
Agora Cancer Research Center, Lausanne, Switzerland.

George Coukos (G)

Department of Oncology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland. george.coukos@chuv.ch.
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne (UNIL), Lausanne, Switzerland. george.coukos@chuv.ch.
Agora Cancer Research Center, Lausanne, Switzerland. george.coukos@chuv.ch.

Classifications MeSH