Horseshoe kidney with teratoid type of Wilms tumor: a rare case report.
Case report
Horseshoe kidney
Pediatrics
Teratoid
Wilms tumor
Journal
BMC nephrology
ISSN: 1471-2369
Titre abrégé: BMC Nephrol
Pays: England
ID NLM: 100967793
Informations de publication
Date de publication:
23 Aug 2024
23 Aug 2024
Historique:
received:
29
03
2024
accepted:
14
08
2024
medline:
24
8
2024
pubmed:
24
8
2024
entrez:
23
8
2024
Statut:
epublish
Résumé
Horseshoe kidney is the most common renal fusion anomaly, and Wilms tumor is the most frequent renal malignancy in children. The occurrence of Wilms tumor in association with horseshoe kidney is a scarce anomaly. However, the arising of a teratoid type, which is a rare variant of Wilms tumor in a horseshoe kidney, is exceptionally unique. This report presents a 5-year-old male admitted with horseshoe kidney involved by a large heterogeneous calcified mass that was diagnose on biopsy as Wilms tumor blastemal dominant. According to the local and regional extension and metastatic tumor in the lungs, the patient underwent neoadjuvant chemotherapy and then surgery. Post-operative pathologic findings confirmed the diagnosis of teratoid Wilms tumor. The occurrence of renal anomalies associated with a malignancy might be more frequent in the clinical environment. There are numerous differential diagnoses for renal tumors and masses, but the possibility of exceptional anomalies should not be denied, and clinicians should be prepared for these occasions. Although studies propose that chemotherapy has a trivial effect on teratoid Wilms tumors, it is essential to evaluate the tumor for any possibility of regression in non-teratoid regions before proceeding to upfront tumoral resection.
Sections du résumé
BACKGROUND
BACKGROUND
Horseshoe kidney is the most common renal fusion anomaly, and Wilms tumor is the most frequent renal malignancy in children. The occurrence of Wilms tumor in association with horseshoe kidney is a scarce anomaly. However, the arising of a teratoid type, which is a rare variant of Wilms tumor in a horseshoe kidney, is exceptionally unique.
CASE PRESENTATION
METHODS
This report presents a 5-year-old male admitted with horseshoe kidney involved by a large heterogeneous calcified mass that was diagnose on biopsy as Wilms tumor blastemal dominant. According to the local and regional extension and metastatic tumor in the lungs, the patient underwent neoadjuvant chemotherapy and then surgery. Post-operative pathologic findings confirmed the diagnosis of teratoid Wilms tumor.
CONCLUSIONS
CONCLUSIONS
The occurrence of renal anomalies associated with a malignancy might be more frequent in the clinical environment. There are numerous differential diagnoses for renal tumors and masses, but the possibility of exceptional anomalies should not be denied, and clinicians should be prepared for these occasions. Although studies propose that chemotherapy has a trivial effect on teratoid Wilms tumors, it is essential to evaluate the tumor for any possibility of regression in non-teratoid regions before proceeding to upfront tumoral resection.
Identifiants
pubmed: 39179960
doi: 10.1186/s12882-024-03709-5
pii: 10.1186/s12882-024-03709-5
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
267Informations de copyright
© 2024. The Author(s).
Références
Bhandarkar KP, Kittur DH, Patil SV, Jadhav SS. Horseshoe kidney and associated anomalies: single institutional review of 20 cases. Afr J Paediatr Surg. 2018;15(2):104–7.
doi: 10.4103/ajps.AJPS_55_17
pubmed: 31290474
pmcid: 6615013
Hamilton TE, Shamberger RC. Wilms tumor: recent advances in clinical care and biology. Semin Pediatr Surg. 2012;21(1):15–20.
doi: 10.1053/j.sempedsurg.2011.10.002
pubmed: 22248966
Lee SH, Bae MH, Choi SH, Lee JS, Cho YS, Joo KJ, Kwon CH, Park HJ. Wilms’ tumor in a horseshoe kidney. Korean J Urol. 2012;53(8):577–80.
doi: 10.4111/kju.2012.53.8.577
pubmed: 22950005
pmcid: 3427845
Choi DJ, Wallace EC, Fraire AE, Baiyee D. Best cases from the AFIP: intrarenal teratoma. Radiographics. 2005;25(2):481–5.
doi: 10.1148/rg.252045153
pubmed: 15798064
Weizer AZ, Silverstein AD, Auge BK, et al. Determining the incidence of horseshoe kidney from radiographic data at a single institution. J Urol. 2003;170(5):1722–6.
doi: 10.1097/01.ju.0000092537.96414.4a
pubmed: 14532762
Farouk AG, Ibrahim HA, Farate A, Wabada S, Mustapha MG. Advanced-stage Wilms tumor arising in a horseshoe kidney of a 9-year-old child: a case report. J Med Case Rep. 2021;15(1):470.
doi: 10.1186/s13256-021-03048-1
pubmed: 34521468
pmcid: 8442335
Luu DT, Duc NM, Tra My TT, Bang LV, Lien Bang MT, Van ND. Wilms’ tumor in horseshoe kidney. Case Rep Nephrol Dial. 2021;11(2):124–8.
doi: 10.1159/000514774
pubmed: 34250029
pmcid: 8255719
Cascio S, Sweeney B, Granata C, Piaggio G, Jasonni V, Puri P, et al. Vesicoureteral reflux and ureteropelvic junction obstruction in children with horseshoe kidney: Treatment and outcome. J Urol. 2002;167(6):2566–8.
doi: 10.1016/S0022-5347(05)65038-0
pubmed: 11992090
Neville H, Ritchey ML, Shamberger RC, Haase G, Perlman S, Yoshioka T. The occurrence of Wilms tumor in horseshoe kidneys: a report from the National Wilms Tumor Study Group (NWTSG). J Pediatr Surg. 2002;37(8):1134–7.
doi: 10.1053/jpsu.2002.34458
pubmed: 12149688
Beckwith JB, Kiviat NB, Bonadio JF. Nephrogenic rests, nephroblastomatosis, and the pathogenesis of Wilms’ tumor. Pediatr Pathol. 1990;10(1–2):1–36.
doi: 10.3109/15513819009067094
pubmed: 2156243
Treger TD, Chowdhury T, Pritchard-Jones K, Behjati S. The genetic changes of Wilms tumour. Nat Rev Nephrol. 2019;15(4):240–51.
doi: 10.1038/s41581-019-0112-0
pubmed: 30705419
Kim S, Chung DH. Pediatric solid malignancies: neuroblastoma and Wilms’ tumor. Surg Clin North Am. 2006;86(2):469-xi 11p13. Proc Natl Acad Sci U S A 1998;95(22):13068-13072.
Miles C, Elgar G, Coles E, Kleinjan DJ, van Heyningen V, Hastie N. Complete sequencing of the Fugu WAGR region from WT1 to PAX6: dramatic compaction and conservation of synteny with human chromosome. pnas. 1998;95(22):13068–72.
Riccardi VM, Sujansky E, Smith AC, Francke U. Chromosomal imbalance in the Aniridia-Wilms’ tumor association: 11p interstitial deletion. Pediatrics. 1978;61(4):604–10.
doi: 10.1542/peds.61.4.604
pubmed: 208044
Pappis CH, Moussatos GH, Constantinides CG, Kairis M. Bilateral nephroblastoma in a horseshoe kidney. J Pediatr Surg. 1979;14(4):483–4.
doi: 10.1016/S0022-3468(79)80025-1
pubmed: 226667
Myers JB, Dall’Era J, Odom LF, McGavran L, Lovell MA, Furness P 3rd. Teratoid Wilms’ tumor, an important variant of nephroblastoma. J Pediatr Urol. 2007;3(4):282–6.
doi: 10.1016/j.jpurol.2006.11.004
pubmed: 18947756
Beckwith JB. Wilms’ tumor and other renal tumors of childhood: a selective review from the National Wilms’ Tumor Study Pathology Center. Hum Pathol. 1983;14(6):481–92.
doi: 10.1016/S0046-8177(83)80003-3
pubmed: 6303938
Magee JF, Ansari S, McFadden DE, Dimmick J. Teratoid Wilms’ tumour: a report of two cases. Histopathology. 1992;20(5):427–31.
doi: 10.1111/j.1365-2559.1992.tb01014.x
pubmed: 1316872
Bhatnagar S. Management of Wilms’ tumor: NWTS vs SIOP. J Indian Assoc Pediatr Surg. 2009;14(1):6–14.
doi: 10.4103/0971-9261.54811
pubmed: 20177436
pmcid: 2809467
Gupta R, Sharma A, Arora R, Dinda AK. Stroma-predominant Wilms tumor with teratoid features: report of a rare case and review of the literature. Pediatr Surg Int. 2009;25(3):293–5.
doi: 10.1007/s00383-009-2333-y
pubmed: 19184050
Vujanić GM, Sandstedt B, Harms D, et al. Revised International Society of Paediatric Oncology (SIOP) working classification of renal tumors of childhood. Med Pediatr Oncol. 2002;38(2):79–82.
doi: 10.1002/mpo.1276
pubmed: 11813170
Inoue M, Uchida K, Kohei O, et al. Teratoid Wilms’ tumor: a case report with literature review. J Pediatr Surg. 2006;41(10):1759–63.
doi: 10.1016/j.jpedsurg.2006.05.045
pubmed: 17011284