Association of polymorphic variants of prolactin (PRL) and beta-lactoglobulin (BLG) genes with resistance/susceptibility to mastitis in holstein cows.
Journal
Brazilian journal of biology = Revista brasleira de biologia
ISSN: 1678-4375
Titre abrégé: Braz J Biol
Pays: Brazil
ID NLM: 101129542
Informations de publication
Date de publication:
2024
2024
Historique:
received:
26
03
2024
accepted:
22
05
2024
medline:
7
8
2024
pubmed:
7
8
2024
entrez:
7
8
2024
Statut:
epublish
Résumé
The work aims to analyze the associations of polymorphic variants of the PRL and BLG genes with resistance and susceptibility to mastitis in Holstein cows. The experimental study consisted of the selection of biomaterial samples from 250 heads of Holstein cows aged 3 years divided into two groups (healthy and with a confirmed diagnosis of mastitis). The determination of animal genotypes was carried out using polymerase chain reaction and restriction fragment length polymorphism. The study of the nature of the association of polymorphic variants of the PRL and BLG gene with resistance/increased risk of mastitis established a significant deviation from the theoretically expected distribution of bBLG-HaeIII genotypes in the group of animals suffering from mastitis (the value of χ2 was 0.24). The bBLG-HaeIIIBB genotype can act as a marker of an increased risk of developing mastitis in Holstein cows; its frequency in the group of sick animals exceeds the frequency in the control group by more than 2 times (44.0 compared to 17.0%, respectively). The bBLG-HaeIIIAB genotype is significantly associated with mastitis resistance in Holstein cows; its frequency is 2 times lower than in the control group (28.0 compared to 54.0%).
Identifiants
pubmed: 39109729
pii: S1519-69842024000101198
doi: 10.1590/1519-6984.284961
pii:
doi:
Substances chimiques
Prolactin
9002-62-4
Lactoglobulins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM