Exploring the biodegradability of candidate metallic intravascular stent materials using X-ray microfocus computed tomography: An in vitro study.
biodegradable stent
high‐resolution microCT
in vitro static immersion testing
metallic alloy
surface properties
Journal
Journal of biomedical materials research. Part B, Applied biomaterials
ISSN: 1552-4981
Titre abrégé: J Biomed Mater Res B Appl Biomater
Pays: United States
ID NLM: 101234238
Informations de publication
Date de publication:
Aug 2024
Aug 2024
Historique:
revised:
07
03
2024
received:
31
08
2023
accepted:
08
07
2024
medline:
23
7
2024
pubmed:
23
7
2024
entrez:
23
7
2024
Statut:
ppublish
Résumé
In vitro testing for evaluating degradation mode and rate of candidate biodegradable metals to be used as intravascular stents is crucial before going to in vivo animal models. In this study, we show that X-ray microfocus computed tomography (microCT) presents a key added value to visualize degradation mode and to evaluate degradation rate and material surface properties in 3D and at high resolution of large regions of interest. The in vitro degradation behavior of three candidate biodegradable stent materials was evaluated: pure iron (Fe), pure zinc (Zn), and a quinary Zn alloy (ZnAgCuMnZr). These metals were compared to a reference biostable cobaltchromium (CoCr) alloy. To compare the degradation mode and degradation rate evaluated with microCT, scanning electron microscopy (SEM) and inductively-coupled plasma (ICP) were included. We confirmed that Fe degrades very slowly but with desirable uniform surface corrosion. Zn degrades faster but exhibits localized deep pitting corrosion. The Zn alloy degrades at a similar rate as the pure Zn, but more homogeneously. However, the formation of deep internal dendrites was observed. Our study provides a detailed microCT-based comparison of essential surface and corrosion properties, with a structural characterization of the corrosion behavior, of different candidate stent materials in 3D in a non-destructive way.
Substances chimiques
Zinc
J41CSQ7QDS
Alloys
0
Iron
E1UOL152H7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e35452Subventions
Organisme : FSR project - Projets Fonds de Recherche Spécial Jeunes Académiques - Fédération Wallonie-Bruxelles
Organisme : Action de Recherche Concertée
ID : ARC 19/24-097
Organisme : SBO project of the Research Foundation Flanders
ID : S007219N
Organisme : Hercules Foundation
ID : AKUL 13/47
Organisme : Fonds de la Recherche Scientifique
ID : EQP - Tomo4D-U.N069.20
Informations de copyright
© 2024 Wiley Periodicals LLC.
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