Imidazoquinoline Derivatives as Potential Inhibitors of InhA Enzyme and
Mycobacterium tuberculosis
/ enzymology
Bacterial Proteins
/ antagonists & inhibitors
Oxidoreductases
/ antagonists & inhibitors
Antitubercular Agents
/ pharmacology
Molecular Docking Simulation
Quinolines
/ chemistry
Imidazoles
/ chemistry
Enzyme Inhibitors
/ chemistry
Structure-Activity Relationship
Microbial Sensitivity Tests
Binding Sites
Molecular Structure
InhA enzyme
imidazoquinoline
inhibitor
mycobacterium tuberculosis
triazolophthalazine
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
27 Jun 2024
27 Jun 2024
Historique:
received:
13
06
2024
revised:
25
06
2024
accepted:
27
06
2024
medline:
13
7
2024
pubmed:
13
7
2024
entrez:
13
7
2024
Statut:
epublish
Résumé
Tuberculosis is a serious public health problem worldwide. The search for new antibiotics has become a priority, especially with the emergence of resistant strains. A new family of imidazoquinoline derivatives, structurally analogous to triazolophthalazines, which had previously shown good antituberculosis activity, were designed to inhibit InhA, an essential enzyme for
Identifiants
pubmed: 38999028
pii: molecules29133076
doi: 10.3390/molecules29133076
pii:
doi:
Substances chimiques
Bacterial Proteins
0
InhA protein, Mycobacterium
EC 1.3.1.9
Oxidoreductases
EC 1.-
Antitubercular Agents
0
Quinolines
0
Imidazoles
0
Enzyme Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM