Early appearance of thyroid autoimmunity in children followed from birth for type 1 diabetes risk.

Thyroid autoimmunity autoimmune thyroid disease children

Journal

The Journal of clinical endocrinology and metabolism

ISSN: 1945-7197

Titre abrégé: J Clin Endocrinol Metab

Pays: United States

ID NLM: 0375362

Informations de publication

Date de publication:
12 Jul 2024

Historique:

received: 11 01 2024

revised: 02 07 2024

accepted: 09 07 2024

medline: 12 7 2024

pubmed: 12 7 2024

entrez: 12 7 2024

Statut: aheadofprint

Résumé

Autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) define pre-clinical autoimmune thyroid disease (AITD) which can progress to either clinical hypo- or hyperthyroidism. We determined the age at seroconversion in children genetically at risk for type 1 diabetes. TPOAb and TgAb seropositivity were determined in 5066 healthy children with HLA DR3 or DR4 containing haplogenotypes from The Environmental Determinants of Diabetes in the Young (TEDDY) Study. Children seropositive on the cross-sectional initial screen at 8-13 years of age had longitudinally collected samples (from 3.5 months of age) screened retrospectively and prospectively for thyroid autoantibodies to identify the age at seroconversion. First-appearing autoantibody was related to sex, HLA genotype, family history of AITD, and subsequent thyroid dysfunction and disease. The youngest appearance of TPOAb and TgAb was 10 and 15 months of age, respectively. Girls had higher incidence rates of both autoantibodies. Family history of AITD was associated with a higher risk of TPOAb hazard ratio [HR] 1.90, 95% confidence interval [CI] 1.17, 3.08; and TgAb HR 2.55, 95% CI 1.91, 3.41. The risk of progressing to hypo- or hyperthyroidism was not different between TgAb and TPOAb, but children with both autoantibodies appearing at the same visit had a higher risk compared to TPOAb appearing first (HR 6.34, 95% CI 2.72, 14.76). Thyroid autoantibodies may appear during the first years of life, especially in girls, and in children with a family history of AITD. Simultaneous appearance of both autoantibodies increases the risk for hypo- or hyperthyroidism.

Identifiants

DOI: 10.1210/clinem/dgae478 PMID: 38996042

pubmed: 38996042

pii: 7712979

doi: 10.1210/clinem/dgae478

pii:

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Investigateurs

Marian Rewers (M)

Kimberly Bautista (K)

Judith Baxter (J)

Daniel Felipe-Morales (D)

Brigitte I Frohnert (BI)

Marisa Stahl (M)

Isabel Flores Garcia (IF)

Patricia Gesualdo (P)

Sierra Hays (S)

Michelle Hoffman (M)

Randi Johnson (R)

Rachel Karban (R)

Edwin Liu (E)

Leila Loaiza (L)

Jill Norris (J)

Holly O'Donnell (H)

Loana Thorndahl (L)

Andrea Steck (A)

Kathleen Waugh (K)

Jorma Toppari (J)

Olli G Simell (OG)

Annika Adamsson (A)

Suvi Ahonen (S)

Mari Åkerlund (M)

Sirpa Anttila (S)

Leena Hakola (L)

Anne Hekkala (A)

Tiia Honkanen (T)

Teija Hurskainen (T)

Heikki Hyöty (H)

Jorma Ilonen (J)

Saori Itoshima (S)

Minna Jokipolvi (M)

Sanna Jokipuu (S)

Taru Karjalainen (T)

Leena Karlsson (L)

Jukka Kero (J)

Marika Korpela (M)

Jaakko J Koskenniemi (JJ)

Miia Kähönen (M)

Mikael Knip (M)

Minna-Liisa Koivikko (ML)

Katja Kokkonen (K)

Merja Koskinen (M)

Mirva Koreasalo (M)

Kalle Kurppa (K)

Salla Kuusela (S)

Jarita Kytölä (J)

Mia Laakso (M)

Jutta Laiho (J)

Tiina Latva-Aho (T)

Siiri Leisku (S)

Laura Leppänen (L)

Katri Lindfors (K)

Maria Lönnrot (M)

Elina Mäntymäki (E)

Markus Mattila (M)

Maija Miettinen (M)

Tiina Niininen (T)

Sari Niinistö (S)

Noora Nurminen (N)

Sami Oikarinen (S)

Hanna-Leena Oinas (HL)

Paula Ollikainen (P)

Zhian Othmani (Z)

Sirpa Pohjola (S)

Solja Raja-Hanhela (S)

Jenna Rautanen (J)

Anne Riikonen (A)

Minna Romo (M)

Juulia Rönkä (J)

Nelli Rönkä (N)

Satu Simell (S)

Aino Tihinen (A)

Päivi Tossavainen (P)

Mari Vähä-Mäkilä (M)

Eeva Varjonen (E)

Riitta Veijola (R)

Irene Viinikangas (I)

Silja Vilmi (S)

Suvi M Virtanen (SM)

Richard McIndoe (R)

Desmond Schatz (D)

Diane Hopkins (D)

Michael Haller (M)

Melissa Gardiner (M)

Ashok Sharma (A)

Laura Jacobsen (L)

Percy Gordon (P)

Jennifer Hosford (J)

Sharon Maina (S)

Chelsea Salmon (C)

Anette G Ziegler (AG)

Ezio Bonifacio (E)

Cigdem Gezginci (C)

Willi Grätz (W)

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Sandra Hummel (S)

Annette Knopff (A)

Sibylle Koletzko (S)

Claudia Ramminger (C)

Roswith Roth (R)

Jennifer Schmidt (J)

Marlon Scholz (M)

Joanna Stock (J)

Katharina Warncke (K)

Lorena Wendel (L)

Christiane Winkler (C)

Helmholtz Zentrum München (HZ)

Forschergruppe Diabetes (F)

Klinikum Rechts der Isar (KR)

Åke Lernmark (Å)

Daniel Agardh (D)

Carin Andrén Aronsson (CA)

Rasmus Bennet (R)

Corrado Cilio (C)

Susanne Dahlberg (S)

Malin Goldman Tsubarah (MG)

Emelie Ericson-Hallström (E)

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Emina Halilovic (E)

Susanne Hyberg (S)

Berglind Jonsdottir (B)

Naghmeh Karimi (N)

Helena Elding Larsson (HE)

Marielle Lindström (M)

Markus Lundgren (M)

Marlena Maziarz (M)

Jessica Melin (J)

Kobra Rahmati (K)

Anita Ramelius (A)

Falastin Salami (F)

Anette Sjöberg (A)

Evelyn Tekum Amboh (ET)

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Ulrika Ulvenhag (U)

Terese Wiktorsson (T)

Åsa Wimar (Å)

William A Hagopian (WA)

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