Using adjusted local assortativity with Molecular Pixelation unveils colocalization of membrane proteins with immunological significance.
Rituximab
graph theory
local assortativity
molecular pixelation
single cell
spatial proteomics
topological data analysis
uropod formation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2024
2024
Historique:
received:
08
10
2023
accepted:
09
04
2024
medline:
10
7
2024
pubmed:
10
7
2024
entrez:
10
7
2024
Statut:
epublish
Résumé
Advances in spatial proteomics and protein colocalization are a driving force in the understanding of cellular mechanisms and their influence on biological processes. New methods in the field of spatial proteomics call for the development of algorithms and open up new avenues of research. The newly introduced Molecular Pixelation (MPX) provides spatial information on surface proteins and their relationship with each other in single cells. This allows for
Identifiants
pubmed: 38983848
doi: 10.3389/fimmu.2024.1309916
pmc: PMC11231075
doi:
Substances chimiques
Membrane Proteins
0
Rituximab
4F4X42SYQ6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1309916Informations de copyright
Copyright © 2024 Rhomberg-Kauert, Karlsson, Thiagarajan, Kallas, Karlsson, Fredriksson, Dahlberg and Martinez Barrio.
Déclaration de conflit d'intérêts
All authors are current or past employees of Pixelgen Technologies AB commercializing products based on Molecular Pixelation.