L-Wnk1 Deletion in Smooth Muscle Cells Causes Aortitis and Inflammatory Shift.

Wnk1 aortitis inflammation phenotype switch smooth muscle cell

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
09 Jul 2024
Historique:
medline: 9 7 2024
pubmed: 9 7 2024
entrez: 9 7 2024
Statut: aheadofprint

Résumé

The long isoform of the Wnk1 (with-no-lysine [K] kinase 1) is a ubiquitous serine/threonine kinase, but its role in vascular smooth muscle cells (VSMCs) pathophysiology remains unknown. AngII (angiotensin II) was infused in Single-cell RNA-sequencing of the aneurysmal abdominal aorta from AngII-infused Wnk1 is a key regulator of VSMC function.

Sections du résumé

BACKGROUND UNASSIGNED
The long isoform of the Wnk1 (with-no-lysine [K] kinase 1) is a ubiquitous serine/threonine kinase, but its role in vascular smooth muscle cells (VSMCs) pathophysiology remains unknown.
METHODS UNASSIGNED
AngII (angiotensin II) was infused in
RESULTS UNASSIGNED
Single-cell RNA-sequencing of the aneurysmal abdominal aorta from AngII-infused
CONCLUSION UNASSIGNED
Wnk1 is a key regulator of VSMC function.

Identifiants

DOI: 10.1161/CIRCRESAHA.124.324366 PMID: 38979610
pubmed: 38979610
doi: 10.1161/CIRCRESAHA.124.324366
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Helene Quelquejay (H)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).
ORCID: 0009-0003-5079-7943

Rida Al-Rifai (R)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).
ORCID: 0000-0002-6976-0011

Michele Silvestro (M)

Division of Vascular and Endovascular Surgery, Department of Surgery and Department of Cell Biology, New York University Langone Medical Center (M.S., B.R.).
ORCID: 0000-0003-1151-2215

Marie Vandestienne (M)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).
ORCID: 0000-0002-6947-9852

Irmine Ferreira (I)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).
ORCID: 0000-0003-1080-8786

Tristan Mirault (T)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).
ORCID: 0000-0001-8690-1093

Henrion Daniel (H)

MITOVASC Department, Team 2 (CarMe), ICAT SFR, University of Angers, Inserm U1083, France (H.D.).
ORCID: 0000-0003-1094-0285

Xiaodan Zhong (X)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).
ORCID: 0000-0001-5268-3905

Icia Santos-Zas (I)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).
Laboratorio de Endocrinología Celular, Área de Endocrinología Molecular y Celular Instituto de Investigación Sanitaria de Santiago, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, Spain (I.S.-Z.).
ORCID: 0000-0002-0310-9074

Guillaume Goudot (G)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).
ORCID: 0000-0003-4327-5568

Paul Alayrac (P)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).
ORCID: 0000-0003-1686-7496

Estelle Robidel (E)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).

Gwennhael Autret (G)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).
ORCID: 0000-0001-7335-350X

Daniel Balvay (D)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).
ORCID: 0000-0003-3802-2224

Soraya Taleb (S)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).
ORCID: 0000-0002-6650-619X

Alain Tedgui (A)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).
ORCID: 0000-0002-7229-4875

Chantal M Boulanger (CM)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).

Alma Zernecke (A)

Institute of Experimental Biomedicine, University Hospital Würzburg, Germany (A.Z.).
ORCID: 0000-0001-8551-4729

Antoine-Emmanuel Saliba (AE)

Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, Würzburg, Germany (A.-E.S., C.C.).
ORCID: 0000-0001-8539-2784

Juliette Hadchouel (J)

Inserm UMRS 1155, Tenon Hospital, Sorbonne Université, Paris, France. (J.H.).
ORCID: 0000-0001-8260-6265

Bhama Ramkhelawon (B)

Division of Vascular and Endovascular Surgery, Department of Surgery and Department of Cell Biology, New York University Langone Medical Center (M.S., B.R.).
ORCID: 0000-0002-9087-0995

Clement Cochain (C)

Helmholtz Institute for RNA-Based Infection Research, Helmholtz-Center for Infection Research, Würzburg, Germany (A.-E.S., C.C.).
ORCID: 0000-0002-0340-1745

Sonia Bergaya (S)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).

Xavier Jeunemaitre (X)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).
ORCID: 0000-0001-5925-381X

Hafid Ait-Oufella (H)

Université de Paris, Inserm U970, Paris-Cardiovascular Research Center, France (H.Q., R.A.-R., M.V., I.F., T.M., X.Z., I.S.-Z., G.G., P.A., E.R., G.A., D.B., S.T., A.T., C.M.B., S.B., X.J., H.A.-O.).
Medical Intensive Care Unit, Hôpital Saint-Antoine, AP-HP, Sorbonne Université, Paris, France. (H.A.-O.).
ORCID: 0000-0002-2955-0183

Classifications MeSH