Bioengineering a plant NLR immune receptor with a robust binding interface toward a conserved fungal pathogen effector.
Oryza
/ microbiology
Plant Diseases
/ microbiology
NLR Proteins
/ metabolism
Plant Proteins
/ metabolism
Fungal Proteins
/ metabolism
Host-Pathogen Interactions
/ immunology
Disease Resistance
/ immunology
Plant Immunity
Bioengineering
/ methods
Magnaporthe
/ immunology
Protein Binding
Receptors, Immunologic
/ metabolism
Ascomycota
NLR
integrated domain
plant immunity
protein structure
recognition
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
09 Jul 2024
09 Jul 2024
Historique:
medline:
5
7
2024
pubmed:
5
7
2024
entrez:
5
7
2024
Statut:
ppublish
Résumé
Bioengineering of plant immune receptors has emerged as a key strategy for generating novel disease resistance traits to counteract the expanding threat of plant pathogens to global food security. However, current approaches are limited by rapid evolution of plant pathogens in the field and may lack durability when deployed. Here, we show that the rice nucleotide-binding, leucine-rich repeat (NLR) immune receptor Pik-1 can be engineered to respond to a conserved family of effectors from the multihost blast fungus pathogen
Identifiants
pubmed: 38968126
doi: 10.1073/pnas.2402872121
doi:
Substances chimiques
NLR Proteins
0
Plant Proteins
0
Fungal Proteins
0
Receptors, Immunologic
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2402872121Subventions
Organisme : UKRI | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/W00108X/1
Organisme : UKRI | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/WW002221/1
Organisme : UKRI | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/V002937/1
Organisme : UKRI | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/V016342
Organisme : UKRI | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/P012574
Organisme : UKRI | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BBS/E/J/000PR9795
Organisme : UKRI | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BBS/E/J/000PR9796
Organisme : UKRI | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/X010996/1
Organisme : UKRI | Biotechnology and Biological Sciences Research Council (BBSRC)
ID : BB/M011216/1
Organisme : EC | ERC | HORIZON EUROPE European Research Council (ERC)
ID : 743165
Organisme : EC | ERC | HORIZON EUROPE European Research Council (ERC)
ID : 101077853
Organisme : John Innes Foundation (JIF)
ID : N/A
Organisme : Gatsby Charitable Foundation (GATSBY)
ID : N/A
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 20H05681
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 23K20042
Déclaration de conflit d'intérêts
Competing interests statement:S.K. receives funding from industry on NLR biology and cofounded a start-up company (Resurrect Bio Ltd.) on resurrecting disease resistance.