Membrane Permeability and Responsiveness Drive Performance: Linking Structural Features with the Antitumor Effectiveness of Doxorubicin-Loaded Stimuli-Triggered Polymersomes.
Journal
Biomacromolecules
ISSN: 1526-4602
Titre abrégé: Biomacromolecules
Pays: United States
ID NLM: 100892849
Informations de publication
Date de publication:
25 Jun 2024
25 Jun 2024
Historique:
medline:
25
6
2024
pubmed:
25
6
2024
entrez:
25
6
2024
Statut:
aheadofprint
Résumé
The permeability and responsiveness of polymer membranes are absolutely relevant in the design of polymersomes for cargo delivery. Accordingly, we herein correlate the structural features, permeability, and responsiveness of doxorubicin-loaded (DOX-loaded) nonresponsive and stimuli-responsive polymersomes with their in vitro and in vivo antitumor performance. Polymer vesicles were produced using amphiphilic block copolymers containing a hydrophilic poly[
Identifiants
pubmed: 38917475
doi: 10.1021/acs.biomac.4c00282
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM