Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis.

Humans Male Female Pursuit, Smooth / physiology Psychotic Disorders / diagnosis Adult Biomarkers Young Adult Bipolar Disorder / diagnosis Middle Aged Case-Control Studies Adolescent
Bipolar Depression Individual prediction Machine learning Psychosis Smooth pursuit eye movements

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
15 Jun 2024
Historique:
received: 11 03 2024
accepted: 10 06 2024
medline: 16 6 2024
pubmed: 16 6 2024
entrez: 15 6 2024
Statut: epublish

Résumé

Smooth pursuit eye movements are considered a well-established and quantifiable biomarker of sensorimotor function in psychosis research. Identifying psychotic syndromes on an individual level based on neurobiological markers is limited by heterogeneity and requires comprehensive external validation to avoid overestimation of prediction models. Here, we studied quantifiable sensorimotor measures derived from smooth pursuit eye movements in a large sample of psychosis probands (N = 674) and healthy controls (N = 305) using multivariate pattern analysis. Balanced accuracies of 64% for the prediction of psychosis status are in line with recent results from other large heterogenous psychiatric samples. They are confirmed by external validation in independent large samples including probands with (1) psychosis (N = 727) versus healthy controls (N = 292), (2) psychotic (N = 49) and non-psychotic bipolar disorder (N = 36), and (3) non-psychotic affective disorders (N = 119) and psychosis (N = 51) yielding accuracies of 65%, 66% and 58%, respectively, albeit slightly different psychosis syndromes. Our findings make a significant contribution to the identification of biologically defined profiles of heterogeneous psychosis syndromes on an individual level underlining the impact of sensorimotor dysfunction in psychosis.

Identifiants

DOI: 10.1038/s41598-024-64487-6 PMID: 38879556
pubmed: 38879556
doi: 10.1038/s41598-024-64487-6
pii: 10.1038/s41598-024-64487-6
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Validation Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

13859

Subventions

Organisme : Innovative Medical Research of the University of Münster Medical School
ID : ME 1 2 18 05
Organisme : German Research Council
ID : LE 1122/7-1

Informations de copyright

© 2024. The Author(s).

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Auteurs

Inga Meyhoefer (I)

Institute for Translational Psychiatry, University of Muenster, Albert Schweitzer Campus 1, Build. A9a, 48149, Muenster, Germany.
Otto-Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Muenster, Muenster, Germany.
Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Duesseldorf/LVR, Duesseldorf, Germany.

Andreas Sprenger (A)

Department of Neurology, University of Luebeck, Luebeck, Germany.

David Derad (D)

Department of Neurology, University of Luebeck, Luebeck, Germany.

Dominik Grotegerd (D)

Institute for Translational Psychiatry, University of Muenster, Albert Schweitzer Campus 1, Build. A9a, 48149, Muenster, Germany.

Ramona Leenings (R)

Institute for Translational Psychiatry, University of Muenster, Albert Schweitzer Campus 1, Build. A9a, 48149, Muenster, Germany.

Elisabeth J Leehr (EJ)

Institute for Translational Psychiatry, University of Muenster, Albert Schweitzer Campus 1, Build. A9a, 48149, Muenster, Germany.

Fabian Breuer (F)

Institute for Translational Psychiatry, University of Muenster, Albert Schweitzer Campus 1, Build. A9a, 48149, Muenster, Germany.

Marian Surmann (M)

Institute for Translational Psychiatry, University of Muenster, Albert Schweitzer Campus 1, Build. A9a, 48149, Muenster, Germany.

Karen Rolfes (K)

Institute for Translational Psychiatry, University of Muenster, Albert Schweitzer Campus 1, Build. A9a, 48149, Muenster, Germany.

Volker Arolt (V)

Institute for Translational Psychiatry, University of Muenster, Albert Schweitzer Campus 1, Build. A9a, 48149, Muenster, Germany.
Otto-Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Muenster, Muenster, Germany.

Georg Romer (G)

Department of Child Adolescence Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany.

Markus Lappe (M)

Otto-Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Muenster, Muenster, Germany.
Institute of Psychology, University of Muenster, Muenster, Germany.

Johanna Rehder (J)

Institute of Psychology, University of Muenster, Muenster, Germany.

Nikolaos Koutsouleris (N)

Department of Psychiatry and Psychotherapy, Ludwig-Maximilian University Munich, Munich, Germany.
Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Max-Planck-Institute of Psychiatry Munich, Munich, Germany.

Stefan Borgwardt (S)

Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany.
Department of Psychiatry, Psychiatric University Hospital, University of Basel, Basel, Switzerland.

Frauke Schultze-Lutter (F)

Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Duesseldorf/LVR, Duesseldorf, Germany.
Department of Psychology, Faculty of Psychology, Airlangga University, Surabaya, Indonesia.
University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.

Eva Meisenzahl (E)

Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Duesseldorf/LVR, Duesseldorf, Germany.

Tilo T J Kircher (TTJ)

Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Marburg, Germany.

Sarah S Keedy (SS)

Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, USA.

Jeffrey R Bishop (JR)

Department of Experimental and Clinical Pharmacology and Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, USA.

Elena I Ivleva (EI)

Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

Jennifer E McDowell (JE)

Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens, GA, USA.

James L Reilly (JL)

Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Scot Kristian Hill (SK)

Department of Psychology, Rosalind Franklin University of Medicine and Science, Chicago, IL, USA.

Godfrey D Pearlson (GD)

Departments of Psychiatry and Neuroscience, Yale School of Medicine, and Olin Research Center, Institute of Living/Hartford Hospital, Hartford, CT, USA.

Carol A Tamminga (CA)

Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

Matcheri S Keshavan (MS)

Department of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Elliot S Gershon (ES)

Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, USA.

Brett A Clementz (BA)

Departments of Psychology and Neuroscience, Bio-Imaging Research Center, University of Georgia, Athens, GA, USA.

John A Sweeney (JA)

Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China.
Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, USA.

Tim Hahn (T)

Institute for Translational Psychiatry, University of Muenster, Albert Schweitzer Campus 1, Build. A9a, 48149, Muenster, Germany.

Udo Dannlowski (U)

Institute for Translational Psychiatry, University of Muenster, Albert Schweitzer Campus 1, Build. A9a, 48149, Muenster, Germany.

Rebekka Lencer (R)

Institute for Translational Psychiatry, University of Muenster, Albert Schweitzer Campus 1, Build. A9a, 48149, Muenster, Germany. lencer@uni-muenster.de.
Otto-Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Muenster, Muenster, Germany. lencer@uni-muenster.de.
Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany. lencer@uni-muenster.de.

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Classifications MeSH

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