Long-term pharmacodynamic and clinical effects of twice- versus once-daily low-dose aspirin in essential thrombocythemia: The ARES trial.


Journal

American journal of hematology
ISSN: 1096-8652
Titre abrégé: Am J Hematol
Pays: United States
ID NLM: 7610369

Informations de publication

Date de publication:
15 Jun 2024
Historique:
revised: 25 05 2024
received: 11 04 2024
accepted: 29 05 2024
medline: 15 6 2024
pubmed: 15 6 2024
entrez: 15 6 2024
Statut: aheadofprint

Résumé

Patients with essential thrombocythemia (ET) are treated with once-daily low-dose aspirin to prevent thrombosis, but their accelerated platelet turnover shortens the antiplatelet effect. The short-term Aspirin Regimens in EsSential Thrombocythemia trial showed that twice-daily aspirin dosing restores persistent platelet thromboxane (TX) inhibition. However, the long-term pharmacodynamic efficacy, safety and tolerability of twice-daily aspirin remain untested. We performed a multicenter, randomized, open-label, blinded-endpoint, phase-2 trial in which 242 patients with ET were randomized to 100 mg aspirin twice- or once-daily and followed for 20 months. The primary endpoint was the persistence of low serum TXB

Identifiants

pubmed: 38877813
doi: 10.1002/ajh.27418
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Agenzia Italiana del Farmaco (AIFA), Ministero della Salute
ID : Study FARM12Y8HH

Investigateurs

Valerio De Stefano (V)
Elena Rossi (E)
Silvia Betti (S)
Tommaso Za (T)
Angela Ciminello (A)
Francesca Bartolomei (F)
Denise Soldati (D)
Giulia De Santis (G)
Carlo Patrono (C)
Bianca Rocca (B)
Giovanna Petrucci (G)
Duaa Hatem (D)
Marco Ruggeri (M)
Alberto Tosetto (A)
Giuseppe Carli (G)
Ilaria Nichele (I)
Stefania Bellesso (S)
Francesco Rodeghiero (F)
Andrea Timillero (A)
Alessandra Iurlo (A)
Daniele Cattaneo (D)
Cristina Bucelli (C)
Silvia Artuso (S)
Alfredo Dragani (A)
Mauro Di Ianni (M)
Paola Ranalli (P)
Giovanna Summa (G)
Celeste Santone (C)
Francesca Palandri (F)
Nicola Vianelli (N)
Giuseppe Auteri (G)
Eloise Beggiato (E)
Giuseppe Lanzarone (G)
Miriana Arminio (M)
Elena Maria Elli (EM)
Stefania Priolo (S)
Nora Giello (N)
Rossella Renso (R)
Maria Luigia Randi (ML)
Irene Bertozzi (I)
Giulia Bogoni (G)
Alessandro Maria Vannucchi (AM)
Paola Guglielmelli (P)
Giuseppe Loscocco (G)
Francesco Mannelli (F)
Giacomo Coltro (G)
Chiara Paoli (C)
Enrica Ravenda (E)
Giorgina Specchia (G)
Francesco Albano (F)
Alessandra Ricco (A)
Paola Carluccio (P)
Marianna Gentile (M)

Informations de copyright

© 2024 The Author(s). American Journal of Hematology published by Wiley Periodicals LLC.

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Auteurs

Bianca Rocca (B)

Department of Safety and Bioethics, Section of Pharmacology, Catholic University School of Medicine, Rome, Italy.
Department NeuroFarBa, University of Florence, Florence, Italy.

Alberto Tosetto (A)

Hematology Department, San Bortolo Hospital, Vicenza, Italy.

Giovanna Petrucci (G)

Department of Safety and Bioethics, Section of Pharmacology, Catholic University School of Medicine, Rome, Italy.
Department of Radiological and Hematological Sciences, Section of Hematology, Catholic University School of Medicine, Roma, Italy.

Elena Rossi (E)

Department of Radiological and Hematological Sciences, Section of Hematology, Catholic University School of Medicine, Roma, Italy.
Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma, Italy.

Silvia Betti (S)

Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma, Italy.

Denise Soldati (D)

Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma, Italy.

Alessandra Iurlo (A)

Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.

Daniele Cattaneo (D)

Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
Department of Oncology and Hemato-Oncology, University of Milan, Milano, Italy.

Cristina Bucelli (C)

Hematology Division, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.

Alfredo Dragani (A)

Hematology Unit, Department of Oncology and Hematology, Ospedale Civile "Santo Spirito", Pescara, Italy.

Mauro Di Ianni (M)

Hematology Unit, Department of Oncology and Hematology, Ospedale Civile "Santo Spirito", Pescara, Italy.
Department of Medicine and Aging Sciences, "G. D'Annunzio" University, Chieti, Italy.

Paola Ranalli (P)

Hematology Unit, Department of Oncology and Hematology, Ospedale Civile "Santo Spirito", Pescara, Italy.
Department of Medicine and Aging Sciences, "G. D'Annunzio" University, Chieti, Italy.

Francesca Palandri (F)

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Istituto di Ematologia "Seràgnoli", Bologna, Italy.

Nicola Vianelli (N)

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, Istituto di Ematologia "Seràgnoli", Bologna, Italy.

Eloise Beggiato (E)

Department of Oncology, Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy.

Giuseppe Lanzarone (G)

Department of Oncology, Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy.

Marco Ruggeri (M)

Hematology Department, San Bortolo Hospital, Vicenza, Italy.

Giuseppe Carli (G)

Hematology Department, San Bortolo Hospital, Vicenza, Italy.

Elena Maria Elli (EM)

Division of Haematology and Bone Marrow Transplantation Unit, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.

Rossella Renso (R)

Division of Haematology and Bone Marrow Transplantation Unit, Fondazione IRCCS San Gerardo Dei Tintori, Monza, Italy.

Maria Luigia Randi (ML)

Department of Medicine-DIMED, University of Padova, Padova, Italy.

Irene Bertozzi (I)

Department of Medicine-DIMED, University of Padova, Padova, Italy.

Giuseppe Gaetano Loscocco (GG)

Department of Experimental and Clinical Medicine, CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy.

Alessandra Ricco (A)

Unit of Hematology and Stem Cell Transplantation, AOU Consorziale Policlinico, Bari, Italy.

Giorgina Specchia (G)

University of Bari Aldo Moro, Bari, Italy.

Alessandro M Vannucchi (AM)

Department of Experimental and Clinical Medicine, CRIMM, Center of Research and Innovation of Myeloproliferative Neoplasms, Azienda Ospedaliero-Universitaria Careggi, University of Florence, Florence, Italy.

Francesco Rodeghiero (F)

Hematology Project Foundation, Affiliated to the Department of Hematology, San Bortolo Hospital, Vicenza, Italy.

Valerio De Stefano (V)

Department of Radiological and Hematological Sciences, Section of Hematology, Catholic University School of Medicine, Roma, Italy.
Fondazione Policlinico Universitario A. Gemelli, IRCCS, Roma, Italy.

Carlo Patrono (C)

Department of Safety and Bioethics, Section of Pharmacology, Catholic University School of Medicine, Rome, Italy.
Center of Excellence on Aging, "G. D'Annunzio" University School of Medicine, Chieti, Italy.

Classifications MeSH