The PDE4 inhibitor apremilast modulates ethanol responses in Gabrb1-S409A knock-in mice via PKA-dependent and independent mechanisms.

Journal

Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217

Informations de publication

Date de publication:
12 Jun 2024
Historique:
received: 09 04 2024
revised: 05 06 2024
accepted: 10 06 2024
medline: 15 6 2024
pubmed: 15 6 2024
entrez: 14 6 2024
Statut: aheadofprint

Résumé

We previously showed that the PDE4 inhibitor apremilast reduces ethanol consumption in mice by protein kinase A (PKA) and GABAergic mechanisms. Preventing PKA phosphorylation of GABA

Identifiants

DOI: 10.1016/j.neuropharm.2024.110035 PMID: 38876310
pubmed: 38876310
pii: S0028-3908(24)00204-1
doi: 10.1016/j.neuropharm.2024.110035
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

110035

Informations de copyright

Copyright © 2024. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of Competing Interest none.

Auteurs

Yuri A Blednov (YA)

Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX 78712.

William Shawlot (W)

Center for Biomedical Research Support, Mouse Genetic Engineering Facility, The University of Texas at Austin, Austin, TX 78712.

Gregg E Homanics (GE)

Departments of Anesthesiology & Perioperative Medicine, Neurobiology, and Pharmacology & Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261.

Elizabeth A Osterndorff-Kahanek (EA)

Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX 78712.

Sonia Mason (S)

Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX 78712.

Jody Mayfield (J)

Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX 78712.

Joshua L Smalley (JL)

Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111.

Stephen J Moss (SJ)

Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111.

Robert O Messing (RO)

Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX 78712; Department of Neuroscience, The University of Texas at Austin, Austin, TX 78712; Department of Neurology, Dell Medical School, The University of Texas at Austin, Austin, TX 78712. Electronic address: romessing@austin.utexas.edu.

Classifications MeSH