Carotid-femoral pulse wave velocity score, an estimator of cognitive performance in the elderly: results from the Toledo Study for Healthy Aging.
Ageing
Arterial stiffness
Carotid-femoral pulse wave velocity (cf-PWV)
Cognitive performance
Neuropsychological evaluation
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
22 May 2024
22 May 2024
Historique:
received:
16
11
2023
accepted:
30
04
2024
medline:
22
5
2024
pubmed:
22
5
2024
entrez:
22
5
2024
Statut:
aheadofprint
Résumé
Ageing-related changes in the vascular wall influence the function of different organs; for this reason, we assessed how arterial stiffness measured by carotid-femoral pulse wave velocity (cf-PWV) modulates: the basal cognitive performance and the change in cognitive performance over the follow-up time. We developed a prospective, population-based cohort study with 1581 participants aged > 65 years were obtained from the Toledo Study for Healthy Aging. Participants from the second wave (2011-2013) were selected for the cross-sectional analysis. Those who also performed the cognitive assessment in the third wave (2015-2017) were selected for the prospective analysis. Arterial stiffness was evaluated by cf-PWV. Multivariate segmented regression models were used to evaluate the association between cf-PWV scores and basal neuropsychological evaluation scores and change of neuropsychological evaluation scores along follow-up. Cross-sectional analysis showed that as cf-PWV grew within the cf-PWV (5- < 10) category an improvement was observed in 7-min test, free short-term memory, and hole peg test. Furthermore, in the cf-PWV (> 13-18) category a decrease was observed in total short-term memory, free long-term memory, and total long-term memory. Prospective analysis showed a progressive worsening of cognitive function as cf-PWV increases within the cf-PWV (> 13-18) category in 7-min test, object denomination, immediate and short-term memory, and hole peg test, while in the cf-PWV (5- < 10) category, there was observed a decrease in Cumulative Executive Dysfunction Index score and short-term memory. In conclusion, a higher cf-PWV score is associated with worse cognitive performance, and with a worse evolution, reinforcing the need to plan interventions to delay arterial stiffness and its consequences.
Identifiants
pubmed: 38776043
doi: 10.1007/s11357-024-01189-x
pii: 10.1007/s11357-024-01189-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI15/01305
Organisme : Instituto de Salud Carlos III
ID : DEP2015-69386-R
Organisme : Instituto de Salud Carlos III
ID : RD12/0043
Organisme : Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable
ID : CB16/10/00456
Organisme : Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable
ID : CB16/10/00464
Organisme : FP7 Health
ID : FP7- 305483-2
Organisme : Junta de Comunidades de Castilla-La Mancha
ID : PI2010/020
Informations de copyright
© 2024. The Author(s), under exclusive licence to American Aging Association.
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