Impact of repeated blast exposure on active-duty United States Special Operations Forces.

Special Operations Forces blast overpressure traumatic brain injury

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
07 May 2024
Historique:
medline: 23 4 2024
pubmed: 23 4 2024
entrez: 22 4 2024
Statut: ppublish

Résumé

United States (US) Special Operations Forces (SOF) are frequently exposed to explosive blasts in training and combat, but the effects of repeated blast exposure (RBE) on SOF brain health are incompletely understood. Furthermore, there is no diagnostic test to detect brain injury from RBE. As a result, SOF personnel may experience cognitive, physical, and psychological symptoms for which the cause is never identified, and they may return to training or combat during a period of brain vulnerability. In 30 active-duty US SOF, we assessed the relationship between cumulative blast exposure and cognitive performance, psychological health, physical symptoms, blood proteomics, and neuroimaging measures (Connectome structural and diffusion MRI, 7 Tesla functional MRI, [

Identifiants

DOI: 10.1073/pnas.2313568121 PMID: 38648470
pubmed: 38648470
doi: 10.1073/pnas.2313568121
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2313568121

Subventions

Organisme : U.S. Department of Defense (DOD)
ID : USSOCOM Contract No. H9240520D0001

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Natalie Gilmore (N)

Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
ORCID: 0000-0002-2935-8386

Chieh-En J Tseng (CJ)

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.
ORCID: 0000-0003-0592-335X

Chiara Maffei (C)

Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.

Samantha L Tromly (SL)

Institute of Applied Engineering, University of South Florida, Tampa, FL 33612.

Katryna B Deary (KB)

Navy SEAL Foundation, Virginia Beach, VA 23455.
ORCID: 0009-0007-9738-5179

Isabella R McKinney (IR)

Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
ORCID: 0009-0007-8105-4674

Jessica N Kelemen (JN)

Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.

Brian C Healy (BC)

Harvard T.H. Chan School of Public Health, Boston, MA 02115.

Collin G Hu (CG)

United States Army Special Operations Aviation Command, Fort Liberty, NC 28307.
Department of Family Medicine, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.

Gabriel Ramos-Llordén (G)

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.

Maryam Masood (M)

Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
ORCID: 0000-0002-1534-8830

Ryan J Cali (RJ)

Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.

Jennifer Guo (J)

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.

Heather G Belanger (HG)

Department of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, FL 33613.
ORCID: 0000-0002-3181-7473

Eveline F Yao (EF)

Office of the Air Force Surgeon General, Falls Church, VA 22042.

Timothy Baxter (T)

Institute of Applied Engineering, University of South Florida, Tampa, FL 33612.

Bruce Fischl (B)

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.
ORCID: 0000-0002-2413-1115

Andrea S Foulkes (AS)

Harvard T.H. Chan School of Public Health, Boston, MA 02115.

Jonathan R Polimeni (JR)

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.

Bruce R Rosen (BR)

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.

Daniel P Perl (DP)

Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814.
ORCID: 0000-0002-4869-924X

Jacob M Hooker (JM)

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.
ORCID: 0000-0002-9394-7708

Nicole R Zürcher (NR)

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.
ORCID: 0000-0003-0271-6304

Susie Y Huang (SY)

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.

W Taylor Kimberly (WT)

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
ORCID: 0000-0002-2519-8530

Douglas N Greve (DN)

Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.
ORCID: 0000-0002-0610-0155

Christine L Mac Donald (CL)

Department of Neurological Surgery, University of Washington, Seattle, WA 98195.
ORCID: 0000-0002-7419-996X

Kristen Dams-O'Connor (K)

Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

Yelena G Bodien (YG)

Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital and Harvard Medical School, Charlestown, MA 02129.

Brian L Edlow (BL)

Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114.
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.
Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129.
ORCID: 0000-0001-7235-8456

Classifications MeSH