Persistent DNA Methylation Changes across the First Year of Life and Prenatal

Journal

Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411

Informations de publication

Date de publication:
Apr 2024
Historique:
medline: 4 4 2024
pubmed: 4 4 2024
entrez: 4 4 2024
Statut: ppublish

Résumé

Evidence suggests that prenatal air pollution exposure alters DNA methylation (DNAm), which could go on to affect long-term health. It remains unclear whether DNAm alterations present at birth persist through early life. Identifying persistent DNAm changes would provide greater insight into the molecular mechanisms contributing to the association of prenatal air pollution exposure with atopic diseases. This study investigated DNAm differences associated with prenatal nitrogen dioxide ( Microarrays measured DNAm at birth and at 1 y of age for an atopy-enriched subset of Canadian Health Infant Longitudinal Development (CHILD) study participants. Individual and regional DNAm differences associated with prenatal At birth ( Regional cord blood DNAm differences associated with prenatal

Sections du résumé

BACKGROUND UNASSIGNED
Evidence suggests that prenatal air pollution exposure alters DNA methylation (DNAm), which could go on to affect long-term health. It remains unclear whether DNAm alterations present at birth persist through early life. Identifying persistent DNAm changes would provide greater insight into the molecular mechanisms contributing to the association of prenatal air pollution exposure with atopic diseases.
OBJECTIVES UNASSIGNED
This study investigated DNAm differences associated with prenatal nitrogen dioxide (
METHODS UNASSIGNED
Microarrays measured DNAm at birth and at 1 y of age for an atopy-enriched subset of Canadian Health Infant Longitudinal Development (CHILD) study participants. Individual and regional DNAm differences associated with prenatal
RESULTS UNASSIGNED
At birth (
DISCUSSION UNASSIGNED
Regional cord blood DNAm differences associated with prenatal

Identifiants

DOI: 10.1289/EHP13034 PMID: 38573328
pubmed: 38573328
doi: 10.1289/EHP13034
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

47004

Auteurs

Samantha Lee (S)

Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.
Biology of Breathing Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.

Hind Sbihi (H)

British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.
School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.

Julia L MacIsaac (JL)

Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.

Robert Balshaw (R)

Centre for Healthcare Innovation, University of Manitoba, Winnipeg, Manitoba, Canada.

Amirthagowri Ambalavanan (A)

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.

Padmaja Subbarao (P)

Department of Pediatrics & Translational Medicine, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Piushkumar J Mandhane (PJ)

Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Faculty of Medicine, USCI University, Kuala Lumpur, Malaysia.

Theo J Moraes (TJ)

Department of Pediatrics & Translational Medicine, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Stuart E Turvey (SE)

BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
ORCID: 0000-0003-1599-1065

Qingling Duan (Q)

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.
School of Computing, Queen's University, Kingston, Ontario, Canada.

Michael Brauer (M)

School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.

Jeffrey R Brook (JR)

Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Michael S Kobor (MS)

Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.
BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.

Meaghan J Jones (MJ)

Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada.
Biology of Breathing Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
ORCID: 0000-0003-1593-997X

Classifications MeSH