Targeting Viral and Cellular Cysteine Proteases for Treatment of New Variants of SARS-CoV-2.
SARS-CoV-2
cysteine protease
pseudovirus technology
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
22 Feb 2024
22 Feb 2024
Historique:
received:
19
12
2023
revised:
12
02
2024
accepted:
19
02
2024
medline:
29
3
2024
pubmed:
28
3
2024
entrez:
28
3
2024
Statut:
epublish
Résumé
The continuous emergence of SARS-CoV-2 variants caused the persistence of the COVID-19 epidemic and challenged the effectiveness of the existing vaccines. The viral proteases are the most attractive targets for developing antiviral drugs. In this scenario, our study explores the use of HIV-1 protease inhibitors against SARS-CoV-2. An in silico screening of a library of HIV-1 proteases identified four anti-HIV compounds able to interact with the 3CL
Identifiants
pubmed: 38543704
pii: v16030338
doi: 10.3390/v16030338
pmc: PMC10976049
pii:
doi:
Substances chimiques
Cysteine Proteases
EC 3.4.-
Protease Inhibitors
0
Antiviral Agents
0
Cysteine Endopeptidases
EC 3.4.22.-
Viral Proteases
EC 3.4.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : World Health Organization
ID : 001
Pays : International
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