PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity.

CP: Cancer CP: Immunology PRMT1 STAT1 argenine methylation cancer immunology

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
23 Feb 2024
Historique:
received: 08 09 2023
revised: 31 12 2023
accepted: 05 02 2024
medline: 24 2 2024
pubmed: 24 2 2024
entrez: 24 2 2024
Statut: aheadofprint

Résumé

Cancer immunotherapies have demonstrated remarkable success; however, the majority of patients do not respond or develop resistance. Here, we conduct epigenetic gene-targeted CRISPR-Cas9 screens to identify epigenomic factors that limit CD8

Identifiants

DOI: 10.1016/j.celrep.2024.113831 PMID: 38401121
pubmed: 38401121
pii: S2211-1247(24)00159-1
doi: 10.1016/j.celrep.2024.113831
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113831

Informations de copyright

Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests S.J.H. is an employee of AbbVie and holds stock in the company. R.W.J. receives research support from Roche, BMS, Astra-Zeneca, Pfizer, and MecRx and is a scientific consultant and shareholder in MecRx.

Auteurs

Tirta M Djajawi (TM)

Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.

Lizzy Pijpers (L)

Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia.

Akash Srivaths (A)

Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.

David Chisanga (D)

Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.

Kok Fei Chan (KF)

Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.

Simon J Hogg (SJ)

Oncology Discovery, AbbVie, South San Francisco, CA 94080, USA.

Liam Neil (L)

Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.

Sarahi Mendoza Rivera (SM)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.

Nenad Bartonicek (N)

Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia.

Sarah L Ellis (SL)

Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.

Terry C C Lim Kam Sian (TCC)

Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; Monash Proteomics and Metabolomics Platform, Department of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC 3800, Australia; Department of Molecular and Translational Science, Faculty of Medicine, Nursing and Health Science, Monash University, Clayton, VIC 3168, Australia.

Pouya Faridi (P)

Centre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia; Monash Proteomics and Metabolomics Platform, Department of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC 3800, Australia; Department of Molecular and Translational Science, Faculty of Medicine, Nursing and Health Science, Monash University, Clayton, VIC 3168, Australia.

Yang Liao (Y)

Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.

Bhupinder Pal (B)

Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.

Andreas Behren (A)

Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.

Wei Shi (W)

Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia.

Stephin J Vervoort (SJ)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia.

Ricky W Johnstone (RW)

Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, VIC 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia.

Conor J Kearney (CJ)

Olivia Newton-John Cancer Research Institute, Heidelberg, VIC 3084, Australia; School of Cancer Medicine, La Trobe University, Melbourne, VIC 3086, Australia. Electronic address: conor.kearney@onjcri.org.au.

Classifications MeSH