Interspecies variability in protein binding of antibiotics basis for translational PK/PD studies-a case study using cefazolin.
antibiotics
cefazolin
equilibrium dialysis
fraction unbound
interspecies differences
pharmacokinetics
plasma protein binding
ultrafiltration
Journal
Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061
Informations de publication
Date de publication:
20 Feb 2024
20 Feb 2024
Historique:
medline:
20
2
2024
pubmed:
20
2
2024
entrez:
20
2
2024
Statut:
aheadofprint
Résumé
For antimicrobial agents in particular, plasma protein binding (PPB) plays a pivotal role in deciphering key properties of drug candidates. Animal models are generally used in the preclinical development of new drugs to predict their effects in humans using translational pharmacokinetics/pharmacodynamics (PK/PD). Thus, we compared the protein binding (PB) of cefazolin as well as bacterial growth under various conditions
Identifiants
pubmed: 38376186
doi: 10.1128/aac.01647-23
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM