New pyrazolylindolin-2-one based coumarin derivatives as anti-melanoma agents: design, synthesis, dual BRAF


Journal

RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657

Informations de publication

Date de publication:
14 Feb 2024
Historique:
received: 06 01 2024
accepted: 29 01 2024
medline: 19 2 2024
pubmed: 19 2 2024
entrez: 19 2 2024
Statut: epublish

Résumé

Malignant melanoma is the most invasive skin cancer with the highest risk of death. The inhibition of BRAF

Identifiants

pubmed: 38370458
doi: 10.1039/d4ra00157e
pii: d4ra00157e
pmc: PMC10870110
doi:

Types de publication

Journal Article

Langues

eng

Pagination

5907-5925

Informations de copyright

This journal is © The Royal Society of Chemistry.

Déclaration de conflit d'intérêts

There are no conflicts of interest to declare.

Auteurs

Ahmed Sabt (A)

Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre Dokki Cairo 12622 Egypt rasha_batran@yahoo.com.

Mohammed A Khedr (MA)

Department of Pharmaceutical Chemistry, College of Pharmacy, Kuwait University Safat 13110 Kuwait.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University 11795 Egypt.

Wagdy M Eldehna (WM)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University Kafrelsheikh 33516 Egypt.

Abdelsamed I Elshamy (AI)

Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre Dokki Cairo 12622 Egypt rasha_batran@yahoo.com.

Mohamed F Abdelhameed (MF)

Pharmacology Department, Medical and Clinical Research Institute, National Research Centre Dokki Cairo 12622 Egypt.

Rasha M Allam (RM)

Pharmacology Department, Medical and Clinical Research Institute, National Research Centre Dokki Cairo 12622 Egypt.

Rasha Z Batran (RZ)

Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre Dokki Cairo 12622 Egypt rasha_batran@yahoo.com.

Classifications MeSH