Neonatal brain dynamic functional connectivity in term and preterm infants and its association with early childhood neurodevelopment.

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
08 Feb 2024
Historique:
received: 28 02 2023
accepted: 28 11 2023
medline: 9 2 2024
pubmed: 9 2 2024
entrez: 8 2 2024
Statut: epublish

Résumé

Brain dynamic functional connectivity characterises transient connections between brain regions. Features of brain dynamics have been linked to emotion and cognition in adult individuals, and atypical patterns have been associated with neurodevelopmental conditions such as autism. Although reliable functional brain networks have been consistently identified in neonates, little is known about the early development of dynamic functional connectivity. In this study we characterise dynamic functional connectivity with functional magnetic resonance imaging (fMRI) in the first few weeks of postnatal life in term-born (n = 324) and preterm-born (n = 66) individuals. We show that a dynamic landscape of brain connectivity is already established by the time of birth in the human brain, characterised by six transient states of neonatal functional connectivity with changing dynamics through the neonatal period. The pattern of dynamic connectivity is atypical in preterm-born infants, and associated with atypical social, sensory, and repetitive behaviours measured by the Quantitative Checklist for Autism in Toddlers (Q-CHAT) scores at 18 months of age.

Identifiants

DOI: 10.1038/s41467-023-44050-z PMID: 38331941
pubmed: 38331941
doi: 10.1038/s41467-023-44050-z
pii: 10.1038/s41467-023-44050-z
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

16

Subventions

Organisme : EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013))
ID : 319456
Organisme : Wellcome Trust (Wellcome)
ID : 203148/Z/16/Z
Organisme : Wellcome Trust (Wellcome)
ID : 206675/Z/17/Z
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/K006355/1
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/P502108/1
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/N026063/1

Informations de copyright

© 2024. The Author(s).

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Auteurs

Lucas G S França (LGS)

Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
Department of Computer and Information Sciences, Faculty of Engineering and Environment, Northumbria University, Newcastle upon Tyne, NE1 8ST, UK.
ORCID: 0000-0003-0853-1319

Judit Ciarrusta (J)

Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.

Oliver Gale-Grant (O)

Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.

Sunniva Fenn-Moltu (S)

Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.

Sean Fitzgibbon (S)

Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, OX3 9DU, UK.

Andrew Chew (A)

Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
ORCID: 0000-0002-4344-2015

Shona Falconer (S)

Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.

Ralica Dimitrova (R)

Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.

Lucilio Cordero-Grande (L)

Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
Biomedical Image Technologies, ETSI Telecomunicación, Universidad Politécnica de Madrid, 28040, Madrid, Spain.
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, 28029, Madrid, Spain.

Anthony N Price (AN)

Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.

Emer Hughes (E)

Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.

Jonathan O'Muircheartaigh (J)

Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK.
ORCID: 0000-0002-8033-6959

Eugene Duff (E)

Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, OX3 9DU, UK.
Department of Brain Sciences, Imperial College London, London, W12 0BZ, UK.
UK Dementia Research Institute at Imperial College London, London, W12 0BZ, UK.

Jetro J Tuulari (JJ)

FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Institute of Clinical Medicine, University of Turku, 20500, Turku, Finland.
Turku Collegium for Science and Medicine and Technology, University of Turku, 20500, Turku, Finland.
Department of Psychiatry, University of Turku and Turku University Hospital, 20500, Turku, Finland.

Gustavo Deco (G)

Center for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Pompeu Fabra University, 08002, Barcelona, Spain.
Catalan Institution for Research and Advanced Studies, 08010, Barcelona, Spain.
Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, 04103, Leipzig, Germany.
School of Psychological Sciences, Monash University, Melbourne, VIC, 3010, Australia.
ORCID: 0000-0002-8995-7583

Serena J Counsell (SJ)

Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.

Joseph V Hajnal (JV)

Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
ORCID: 0000-0002-2690-5495

Chiara Nosarti (C)

Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
ORCID: 0000-0001-6305-9710

Tomoki Arichi (T)

Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK.
Department of Paediatric Neurosciences, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.
Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK.
ORCID: 0000-0002-3550-1644

A David Edwards (AD)

Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK.
MRC Centre for Neurodevelopmental Disorders, King's College London, London, SE1 1UL, UK.
ORCID: 0000-0003-4801-7066

Grainne McAlonan (G)

Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK.
ORCID: 0000-0002-4466-2343

Dafnis Batalle (D)

Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK. dafnis.batalle@kcl.ac.uk.
Centre for the Developing Brain, School of Biomedical Engineering & Imaging Sciences, King's College London, London, SE1 7EH, UK. dafnis.batalle@kcl.ac.uk.
ORCID: 0000-0003-2097-979X

Classifications MeSH