Sweet dreams: glycosylation controls tumor cell dormancy.

dormancy extracellular matrix glycosylation metastasis

Journal

Trends in cancer

ISSN: 2405-8025

Titre abrégé: Trends Cancer

Pays: United States

ID NLM: 101665956

Informations de publication

Date de publication:
03 Feb 2024

Historique:

received: 16 01 2024

accepted: 24 01 2024

medline: 5 2 2024

pubmed: 5 2 2024

entrez: 4 2 2024

Statut: aheadofprint

Résumé

In a recent study in Cancer Cell, Sreekumar et al. used therapy-associated breast cancer mouse models as well as in vitro dormancy models to identify extracellular matrix (ECM)-related tumor cell-autonomous mechanisms of dormancy in residual tumor cells (RTCs). The study reveals an important role of the glycosylation of proteoglycans in sustaining dormancy and opens the door to leverage this biology to eliminate RTCs and prevent recurrence.

Identifiants

DOI: 10.1016/j.trecan.2024.01.011 PMID: 38311543

pubmed: 38311543

pii: S2405-8033(24)00011-6

doi: 10.1016/j.trecan.2024.01.011

pii:

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Informations de copyright

Déclaration de conflit d'intérêts

Declaration of interests No interests are declared.