Megaprosthetic replacement in complex distal humerus fractures in elderly patients: a case series.

Distal humerus Distal humerus fractures Elbow Elbow replacement Elderly Megaprostheses Megaprosthesis

Journal

Journal of orthopaedic surgery and research
ISSN: 1749-799X
Titre abrégé: J Orthop Surg Res
Pays: England
ID NLM: 101265112

Informations de publication

Date de publication:
11 Jan 2024
Historique:
received: 14 10 2023
accepted: 12 12 2023
medline: 12 1 2024
pubmed: 12 1 2024
entrez: 11 1 2024
Statut: epublish

Résumé

Managing distal humeral fractures can be challenging for orthopedic surgeons. There are several treatment options for managing this type of fracture, and the treatment method for these fractures should be based on patient-related factors. In elderly patients with osteoporotic bone and severe comminution of the fracture, adequate fixation can be a major challenge for surgeons. The use of megaprosthesis has been recently proposed in traumatology as an alternative to osteosynthesis or conventional prosthesis for the management of comminuted articular fractures in elderly patients with poor bone stock. A consecutive case series of 5 patients who underwent reconstruction of the elbow joint with a trabecular hinged modular elbow megaprosthesis was reviewed retrospectively. All patients included had AO/OTA 13C2 and 13C3 fractures with metaphyseal extension and considerable bone loss of the distal humerus. The primary outcome was the evaluation of functional and clinical outcomes with the MEPS score in comminuted distal humerus fractures with metaphyseal extension and poor bone stock in elderly patients treated with elbow megaprosthesis. The secondary outcome was assessing the treatment-related complication rate of this technique in non-oncological fields. Five patients were included in the study with a mean age of 82.66 ± 7.72 years at surgery. The mean MEPS value was 63 ± 24.2 at 1 month, 81 ± 23.53 at 3 months, 83 ± 24.2 at 6 months, and 84 ± 24.57 at 12 months. No intraoperative complications were recorded in our series. Of 5 patients, four patients had excellent clinical and functional outcomes. We did not encounter wound dehiscence, prosthetic joint infection, aseptic loosening, or periprosthetic fractures. The indication for this type of treatment must be selected and narrowed down, as it is a salvage procedure, and any failure would cause even more complex situations. Short operating times and early mobilization of the elbow are the advantages of this technique.

Sections du résumé

BACKGROUND BACKGROUND
Managing distal humeral fractures can be challenging for orthopedic surgeons. There are several treatment options for managing this type of fracture, and the treatment method for these fractures should be based on patient-related factors. In elderly patients with osteoporotic bone and severe comminution of the fracture, adequate fixation can be a major challenge for surgeons. The use of megaprosthesis has been recently proposed in traumatology as an alternative to osteosynthesis or conventional prosthesis for the management of comminuted articular fractures in elderly patients with poor bone stock.
METHODS METHODS
A consecutive case series of 5 patients who underwent reconstruction of the elbow joint with a trabecular hinged modular elbow megaprosthesis was reviewed retrospectively. All patients included had AO/OTA 13C2 and 13C3 fractures with metaphyseal extension and considerable bone loss of the distal humerus. The primary outcome was the evaluation of functional and clinical outcomes with the MEPS score in comminuted distal humerus fractures with metaphyseal extension and poor bone stock in elderly patients treated with elbow megaprosthesis. The secondary outcome was assessing the treatment-related complication rate of this technique in non-oncological fields.
RESULTS RESULTS
Five patients were included in the study with a mean age of 82.66 ± 7.72 years at surgery. The mean MEPS value was 63 ± 24.2 at 1 month, 81 ± 23.53 at 3 months, 83 ± 24.2 at 6 months, and 84 ± 24.57 at 12 months. No intraoperative complications were recorded in our series. Of 5 patients, four patients had excellent clinical and functional outcomes. We did not encounter wound dehiscence, prosthetic joint infection, aseptic loosening, or periprosthetic fractures.
CONCLUSIONS CONCLUSIONS
The indication for this type of treatment must be selected and narrowed down, as it is a salvage procedure, and any failure would cause even more complex situations. Short operating times and early mobilization of the elbow are the advantages of this technique.

Identifiants

pubmed: 38212796
doi: 10.1186/s13018-023-04465-2
pii: 10.1186/s13018-023-04465-2
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

53

Informations de copyright

© 2024. The Author(s).

Références

Galano GJ, Ahmad CS, Levine WN. Current treatment strategies for bicolumnar distal humerus fractures. J Am Acad Orthop Surg. 2010;18(1):20–30.
doi: 10.5435/00124635-201001000-00004 pubmed: 20044489
Nauth A, McKee MD, Ristevski B, Hall J, Schemitsch EH. Distal humeral fractures in adults. J Bone Joint Surg Am. 2011;93(7):686–700(Https://Doi.Org/10.2106/JBJS.J.00845).
doi: 10.2106/JBJS.J.00845 pubmed: 21471423
Lauder A, Richard MJ. Management of distal humerus fractures. Eur J Orthop Surg Traumatol. 2020;30(5):745–62. https://doi.org/10.1007/S00590-020-02626-1 . (Epub 2020 Jan 21 PMID: 31965305).
doi: 10.1007/S00590-020-02626-1 pubmed: 31965305
Meinberg EG, Agel J, Roberts CS, Karam MD, Kellam JF. Fracture and dislocation classification compendium-2018. J Orthop Trauma. 2018;32(Suppl 1):S1–170. https://doi.org/10.1097/BOT.0000000000001063 . (PMID: 29256945).
doi: 10.1097/BOT.0000000000001063 pubmed: 29256945
Mehlhoff TL, Bennett JB. Distal humeral fractures: fixation versus arthroplasty. J Shoulder Elbow Surg. 2011;20(2 Suppl):S97-106. https://doi.org/10.1016/j.Jse.2010.11.012 .
doi: 10.1016/j.Jse.2010.11.012 pubmed: 21281926
Martin S, Sanchez E. Anatomy and biomechanics of the elbow joint. Semin Musculoskelet Radiol. 2013;17(5):429–36. https://doi.org/10.1055/s-0033-1361587 . (Epub 2013 Dec 10 PMID: 24327407).
doi: 10.1055/s-0033-1361587 pubmed: 24327407
Plath JE, Förch S, Haufe T, Mayr EJ. Ellenbogenfraktur Im Alter—Erhalt Oder Ersatz? [Distal Humerus Fracture in the Elderly]. Z Orthop Unfall. 2018;156(1):30–40. https://doi.org/10.1055/s-0043-121893 . (Epub 2018 Jan 11. PMID: 29325184).
doi: 10.1055/s-0043-121893 pubmed: 29325184
Morrey ME, Morrey BF, Sanchez-Sotelo J, Barlow JD, O’Driscoll S. A review of the surgical management of distal humerus fractures and nonunions: from fixation to arthroplasty. J Clin Orthop Trauma. 2021;12(20): 101477. https://doi.org/10.1016/j.Jcot.2021.101477.PMID:34211832;PMCID:PMC8237363 .
doi: 10.1016/j.Jcot.2021.101477.PMID:34211832;PMCID:PMC8237363
Desloges W, Faber KJ, King GJ, Athwal GS. Functional outcomes of distal humeral fractures managed nonoperatively in medically unwell and lower-demand elderly patients. J Shoulder Elbow Surg. 2015;24(8):1187–96. https://doi.org/10.1016/j.Jse.2015.05.032 .
doi: 10.1016/j.Jse.2015.05.032 pubmed: 26189804
McKee MD, Veillette CJ, Hall JA, Schemitsch EH, Wild LM, McCormack R, Perey B, Goetz T, Zomar M, Moon K, Mandel S, Petit S, Guy P, Leung I. A multicenter, prospective, randomized, controlled trial of open reduction—internal fixation versus total elbow arthroplasty for displaced intra-articular distal humeral fractures in elderly patients. J Shoulder Elbow Surg. 2009;18(1):3–12. https://doi.org/10.1016/j.Jse.2008.06.005 .
doi: 10.1016/j.Jse.2008.06.005 pubmed: 18823799
Kharrazi FD, Busfield BT, Khorshad DS, Hornicek FJ, Mankin HJ. Osteoarticular and total elbow allograft reconstruction with severe bone loss. Clin Orthop Relat Res. 2008;466(1):205–9. https://doi.org/10.1007/S11999-007-0011-8 .(PMID: 18196394; PMCID: PMC2505305).
doi: 10.1007/S11999-007-0011-8 pubmed: 18196394 pmcid: 2505305
Funovics PT, Schuh R, Adams SB Jr, Sabeti-Aschraf M, Dominkus M, Kotz RI. Modular prosthetic reconstruction of major bone defects of the distal end of the humerus. J Bone Joint Surg Am. 2011;93:1064–74.
doi: 10.2106/JBJS.J.00239 pubmed: 21655900
Moghaddam-Alvandi A, Dremel E, Güven F, Heppert V, Wagner C, Studier-Fischer S, Grützner PA, Biglari B. Ellenbogengelenkarthrodese. Indikation, Operationsverfahren Und Klinische Ergebnisse [Arthrodesis of the elbow joint. indications, surgical technique and clinical results]. Unfallchirurg. 2010;113(4):300–7. https://doi.org/10.1007/S00113-009-1722-y .
doi: 10.1007/S00113-009-1722-y pubmed: 20224987
Morrey ME, Sanchez-Sotelo J, Abdel MP, Morrey BF. Allograft-prosthetic composite reconstruction for massive bone loss including catastrophic failure in total elbow arthroplasty. J Bone Joint Surg Am. 2013;95(12):1117–24. https://doi.org/10.2106/JBJS.L.00747 .(PMID: 23783209).
doi: 10.2106/JBJS.L.00747 pubmed: 23783209
Koller H, Kolb K, Assuncao A, Kolb W, Holz U. The fate of elbow arthrodesis: indications, techniques, and outcome in fourteen patients. J Shoulder Elbow Surg. 2008;17(2):293–306. https://doi.org/10.1016/j.jse.2007.06.008 .
doi: 10.1016/j.jse.2007.06.008 pubmed: 18036845
Vitiello R, Matrangolo MR, El Motassime A, Perna A, Cianni L, Maccauro G, Ziranu A. Three-dimension-printed custom-made prosthetic reconstructions in bone tumors: a single center experience. Curr Oncol. 2022;29(7):4566–77. https://doi.org/10.3390/Curroncol29070361.PMID:35877221;PMCID:PMC9322169 .
doi: 10.3390/Curroncol29070361.PMID:35877221;PMCID:PMC9322169 pubmed: 35877221 pmcid: 9322169
Piccioli A, Donati F, Giacomo GD, Ziranu A, Careri S, Spinelli MS, Giannini S, Giannicola G, Perisano C, Maccauro G. Infective complications in tumour endoprostheses implanted after pathological fracture of the limbs. Injury. 2016;47(Suppl 4):S22–8.
doi: 10.1016/j.injury.2016.07.054 pubmed: 27568843
Rajasekaran RB, Palanisami DR, Natesan R, Jayaramaraju D, Rajasekaran S. Megaprosthesis in distal femur nonunions in elderly patients—experience from twenty four cases. Int Orthop. 2020;44:677–84.
doi: 10.1007/s00264-019-04383-1 pubmed: 31392494
Vitiello R, Smimmo A, De Fazio A, Bocchi MB, Oliva MS, Perna A, Maccauro G, Ziranu A. Megaprosthesis in articular fractures of the lower limbs in fragile patients: a proposal for the therapeutic algorithm. Eur Rev Med Pharmacol Sci. 2022;26(1 Suppl):84–91. https://doi.org/10.26355/Eurrev_202211_30286.PMID:36448860.8,17 .
doi: 10.26355/Eurrev_202211_30286.PMID:36448860.8,17 pubmed: 36448860
Capanna R, Muratori F, Campo FR, D’Arienzo A, Frenos F, Beltrami G, Scoccianti G, Cuomo P, Piccioli A, Müller DA. Modular megaprosthesis reconstruction for oncological and non-oncological resection of the elbow joint. Injury. 2016;47(Suppl 4):S78–83. https://doi.org/10.1016/j.Injury.2016.07.041 . (Epub 2016 Aug 18 PMID: 27546723).
doi: 10.1016/j.Injury.2016.07.041 pubmed: 27546723
Agha RA, Sohrabi C, Mathew G, Franchi T, Kerwan A, O’Neill N, PROCESS Group. The PROCESS 2020 guideline: updating consensus preferred reporting of case series in surgery (PROCESS) guidelines. Int J Surg. 2020;84:231–5. https://doi.org/10.1016/j.Ijsu.2020.11.005 . (Epub 2020 Nov 12. PMID: 33189880).
doi: 10.1016/j.Ijsu.2020.11.005 pubmed: 33189880
D’Adamio S, Ziranu A, Cazzato G, Sanguinetti M, Manicone PF, Rosa MA, Maccauro G. Antifungal properties of silver coating on tumour endoprostheses: an in vitro study. Eur Rev Med Pharmacol Sci. 2019;23(2 Suppl):252–7. https://doi.org/10.26355/Eurrev_201904_17499 . (PMID: 30977892).
doi: 10.26355/Eurrev_201904_17499 pubmed: 30977892
Ziranu A, Lillo M, Fantoni M, Maffulli N, Maccauro G. Single dose cefazolin is safe and effective for pre-operative prophylaxis in orthopaedic oncology. J Biol Regul Homeost Agents. 2018;32(6 Suppl. 1):45–9 (PMID: 30644281).
pubmed: 30644281
Cusick MC, Bonnaig NS, Azar FM, Mauck BM, Smith RA, Throckmorton TW. Accuracy and reliability of the mayo elbow performance score. J Hand Surg Am. 2014;39(6):1146–50. https://doi.org/10.1016/j.Jhsa.2014.01.041 . (Epub 2014 Mar 20 PMID: 24656392).
doi: 10.1016/j.Jhsa.2014.01.041 pubmed: 24656392
Parvizi J, Zmistowski B, Berbari EF, et al. New definition for periprosthetic joint infection: 282 from the workgroup of the musculoskeletal infection society. Clin Orthop. 2011;469(11):2992–4. https://doi.org/10.1007/S11999-011-2102-9 .
doi: 10.1007/S11999-011-2102-9 pubmed: 21938532 pmcid: 3183178
Larry L, Hench L. In Biomaterials, artificial organs and tissue engineering (2005).
Capone A, Congia S, Civinini R, Marongiu G. Periprosthetic fractures: epidemiology and current treatment. Clin Cases Miner Bone Metab. 2017;14(2):189–96. https://doi.org/10.11138/Ccmbm/2017.14.1.189 . (Epub 2017 Oct 25. PMID: 29263732; PMCID: PMC5726208).
doi: 10.11138/Ccmbm/2017.14.1.189 pubmed: 29263732 pmcid: 5726208
Horan TC, Gaynes RP, Martone WJ, Jarvis WR, Emori TG. CDC Definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control Hosp Epidemiol Ottobre. 1992;13(10):606–8.
doi: 10.2307/30148464
Laumonerie P, Granjou J, Tibbo ME, Massin V, Bonnevialle N, Mansat P. Midterm outcomes allograft prosthetic composite reconstruction for massive bone loss at the elbow. Orthop Traumatol Surg Res. 2022;10:103517. https://doi.org/10.1016/j.Otsr.2022.103517 . (Epub Ahead of Print. PMID: 36513324).
doi: 10.1016/j.Otsr.2022.103517
Graham TJ, Fitzgerald MS. The destroyed elbow. Am J Orthop (Belle Mead NJ). 2000;29(9 Suppl):9–15(PMID: 11011774).
pubmed: 11011774
Loisel F, Amar Y, Rochet S, Obert L. Distal humerus fracture in older patients: ORIF vs total elbow arthroplasty. Orthop Traumatol Surg Res. 2023;20:103759. https://doi.org/10.1016/j.otsr.2023.103759 .
doi: 10.1016/j.otsr.2023.103759
Lundh F, Sayed-Noor AS, Brosjö O, Bauer H. Megaprosthetic reconstruction for periprosthetic or highly comminuted fractures of the hip and knee. Eur J Orthop Surg Traumatol. 2014;24(4):553–7. https://doi.org/10.1007/S00590-013-1237-7 . (Epub 2013 May 21 PMID: 23689913).
doi: 10.1007/S00590-013-1237-7 pubmed: 23689913
Windhager R, Schreiner M, Staats K, Apprich S. Megaprostheses in the treatment of periprosthetic fractures of the knee joint: indication, technique, results and review of literature. Int Orthop. 2016;40(5):935–43. https://doi.org/10.1007/S00264-015-2991-4 . (Epub 2015 Sep 25 PMID: 26404093).
doi: 10.1007/S00264-015-2991-4 pubmed: 26404093
Vitiello R, Ziranu A, Oliva MS, Meluzio MC, Cauteruccio M, Maccauro G, Liuzza F, Saccomanno MF. The value of megaprostheses in non-oncological fractures in elderly patients: a shortterm results: a short-term result. Injury. 2022;53:1241–6.
doi: 10.1016/j.injury.2021.09.026 pubmed: 34602244
Ziranu A, Bocchi MB, Oliva MS, Meschini C, Messina F, Calori S, Vitiello R. Survivorship of proximal femoral replacement in neoplastic and non-neoplastic elderly patients. Eur Rev Med Pharmacol Sci. 2022;26(1 Suppl):106–12. https://doi.org/10.26355/eurrev_202211_30289 . (PMID: 36448862).
doi: 10.26355/eurrev_202211_30289 pubmed: 36448862
Tran Trung D, Tran Q, Vu TuN, Nguyen Tran Quang S, Nguyen Huu M, Pham Trung H. Non-oncologic indication for elbow megaprothesis replacement: 2 cases report. Int J Surg Case Rep. 2021;86:106356. https://doi.org/10.1016/j.Ijscr.2021.106356 . (Epub 2021 Sep 1. PMID: 34507188; PMCID: PMC8430374).
doi: 10.1016/j.Ijscr.2021.106356 pubmed: 34507188 pmcid: 8430374
El Ezzo O, Oliva MS, Cauteruccio M, Saracco M, Vitiello R, Maccauro G, Perisano C. Innovations in prevention of infections in oncological megaprostheses: a narrative review. J Biol Regul Homeost Agents. 2020;34(4):275–8.
pubmed: 33261289

Auteurs

Matteo Caredda (M)

Department of Ageing, Neurosciences, Head-Neck and Orthopedics Sciences, Orthopedics and Trauma Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.
Orthopedics and Trauma Surgery, Università Cattolica del Sacro Cuore, 00168, Rome, Italy.

Luigi Cianni (L)

Department of Ageing, Neurosciences, Head-Neck and Orthopedics Sciences, Orthopedics and Trauma Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy. luigi_cianni@libero.it.
Orthopedics and Trauma Surgery, Università Cattolica del Sacro Cuore, 00168, Rome, Italy. luigi_cianni@libero.it.

Andrea De Fazio (A)

Department of Ageing, Neurosciences, Head-Neck and Orthopedics Sciences, Orthopedics and Trauma Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.
Orthopedics and Trauma Surgery, Università Cattolica del Sacro Cuore, 00168, Rome, Italy.

Antonio Ziranu (A)

Orthopedics and Trauma Surgery, Università Cattolica del Sacro Cuore, 00168, Rome, Italy.

Raffaele Vitiello (R)

Department of Ageing, Neurosciences, Head-Neck and Orthopedics Sciences, Orthopedics and Trauma Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.

Giulio Maccauro (G)

Department of Ageing, Neurosciences, Head-Neck and Orthopedics Sciences, Orthopedics and Trauma Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168, Rome, Italy.
Orthopedics and Trauma Surgery, Università Cattolica del Sacro Cuore, 00168, Rome, Italy.

Classifications MeSH