Electrophysiological neuromuscular alterations and severe fatigue predict long-term muscle weakness in survivors of COVID-19 acute respiratory distress syndrome.

COVID-19 acute respiratory distress syndrome electrical neuromuscular function fatigue muscle weakness

Journal

Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899

Informations de publication

Date de publication:
2023
Historique:
received: 08 06 2023
accepted: 27 10 2023
medline: 11 12 2023
pubmed: 11 12 2023
entrez: 11 12 2023
Statut: epublish

Résumé

Long-term weakness is common in survivors of COVID-19-associated acute respiratory distress syndrome (CARDS). We longitudinally assessed the predictors of muscle weakness in patients evaluated 6 and 12 months after intensive care unit discharge with in-person visits. Muscle strength was measured by isometric maximal voluntary contraction (MVC) of the tibialis anterior muscle. Candidate predictors of muscle weakness were follow-up time, sex, age, mechanical ventilation duration, use of steroids in the intensive care unit, the compound muscle action potential of the tibialis anterior muscle (CMAP-TA-S100), a 6-min walk test, severe fatigue, depression and anxiety, post-traumatic stress disorder, cognitive assessment, and body mass index. We also compared the clinical tools currently available for the evaluation of muscle strength (handgrip strength and Medical Research Council sum score) and electrical neuromuscular function (simplified peroneal nerve test [PENT]) with more objective and robust measures of force (MVC) and electrophysiological evaluation of the neuromuscular function of the tibialis anterior muscle (CMAP-TA-S100) for their essential role in ankle control. MVC improved at 12 months compared with 6 months. CMAP-TA-S100 ( Electrical neuromuscular abnormalities and severe fatigue are independently associated with reduced MVC and can be used to predict the risk of long-term muscle weakness in CARDS survivors.

Identifiants

DOI: 10.3389/fneur.2023.1235734 PMID: 38073634 PMC: PMC10702731
pubmed: 38073634
doi: 10.3389/fneur.2023.1235734
pmc: PMC10702731
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1235734

Informations de copyright

Copyright © 2023 Benedini, Cogliati, Lulic-Kuryllo, Peli, Mombelli, Calza, Guarneri, Cudicio, Rizzardi, Bertoni, Gazzina, Renzi, Gitti, Rasulo, Goffi, Pozzi, Orizio, Negro, Latronico and Piva.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Marco Benedini (M)

Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Marta Cogliati (M)

Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Tea Lulic-Kuryllo (T)

Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Elena Peli (E)

Department of Anesthesia, Critical Care and Emergency, ASST Spedali Civili University Hospital, Brescia, Italy.

Stefano Mombelli (S)

Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.

Stefano Calza (S)

Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Bruno Guarneri (B)

Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.

Alessandro Cudicio (A)

Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Andrea Rizzardi (A)

Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Michele Bertoni (M)

Department of Anesthesia, Critical Care and Emergency, ASST Spedali Civili University Hospital, Brescia, Italy.

Stefano Gazzina (S)

Department of Continuity of Care and Frailty, Neurology Unit, ASST Spedali Civili, Brescia, Italy.

Stefania Renzi (S)

Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.

Nicola Gitti (N)

Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.

Frank A Rasulo (FA)

Department of Anesthesia, Critical Care and Emergency, ASST Spedali Civili University Hospital, Brescia, Italy.
Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
"Alessandra Bono" Interdepartmental University Research Center on LOng-Term Outcome (LOTO) in Critical Illness Survivors, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.

Alberto Goffi (A)

Department of Medicine and Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.
St. Michael's Hospital and Li Ka Shing Knowledge Institute, Keenan Research Centre, Unity Health Toronto, Toronto, ON, Canada.

Matteo Pozzi (M)

Department of Emergency and Intensive Care, ASST Monza, Monza, Italy.

Claudio Orizio (C)

Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
"Teresa Camplani" Interdepartmental University Research Center on the Neuromuscular Function and the Adapted Motor Activity, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Francesco Negro (F)

Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Nicola Latronico (N)

Department of Anesthesia, Critical Care and Emergency, ASST Spedali Civili University Hospital, Brescia, Italy.
Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
"Alessandra Bono" Interdepartmental University Research Center on LOng-Term Outcome (LOTO) in Critical Illness Survivors, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.

Simone Piva (S)

Department of Anesthesia, Critical Care and Emergency, ASST Spedali Civili University Hospital, Brescia, Italy.
Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.

Classifications MeSH