Pharmacokinetics of dexmedetomidine in anaesthetized horses following repeated subcutaneous administration and intravenous constant rate infusion.
Balanced anaesthesia
Constant rate infusion
Dexmedetomidine
Equine patient
Liquid Chromatography Mass Spectrometry
Pharmacokinetics
Subcutaneous
Journal
BMC veterinary research
ISSN: 1746-6148
Titre abrégé: BMC Vet Res
Pays: England
ID NLM: 101249759
Informations de publication
Date de publication:
09 Dec 2023
09 Dec 2023
Historique:
received:
06
07
2023
accepted:
29
11
2023
medline:
10
12
2023
pubmed:
10
12
2023
entrez:
9
12
2023
Statut:
epublish
Résumé
The inclusion of dexmedetomidine (DEX) within a balanced general anaesthesia protocol is effective in improving the clinical outcome and recovery quality of anaesthesia in horses. This study aimed to determine the pharmacokinetic profile of DEX following repeated subcutaneous (SC) administration at 2 µg/kg every 60 min till the end of the procedure in comparison to intravenous constant rate infusion (CRI) at 1 µg/kg/h in anaesthetized horses undergoing diagnostic procedures up to the end of the diagnostic procedure. In the CRI and SC groups DEX maximum concentrations (C The pharmacokinetic profile of DEX following repeated SC administration in anaesthetized horses was comparable to intravenous CRI administration during the intranaesthetic period and beneficial during the recovery phase from general anaesthesia. The SC route could be considered as an alternative to CRI for improving the recovery quality of equine patients undergoing general anaesthesia.
Sections du résumé
BACKGROUND
BACKGROUND
The inclusion of dexmedetomidine (DEX) within a balanced general anaesthesia protocol is effective in improving the clinical outcome and recovery quality of anaesthesia in horses. This study aimed to determine the pharmacokinetic profile of DEX following repeated subcutaneous (SC) administration at 2 µg/kg every 60 min till the end of the procedure in comparison to intravenous constant rate infusion (CRI) at 1 µg/kg/h in anaesthetized horses undergoing diagnostic procedures up to the end of the diagnostic procedure.
RESULTS
RESULTS
In the CRI and SC groups DEX maximum concentrations (C
CONCLUSIONS
CONCLUSIONS
The pharmacokinetic profile of DEX following repeated SC administration in anaesthetized horses was comparable to intravenous CRI administration during the intranaesthetic period and beneficial during the recovery phase from general anaesthesia. The SC route could be considered as an alternative to CRI for improving the recovery quality of equine patients undergoing general anaesthesia.
Identifiants
pubmed: 38071301
doi: 10.1186/s12917-023-03831-w
pii: 10.1186/s12917-023-03831-w
pmc: PMC10709979
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
264Informations de copyright
© 2023. The Author(s).
Références
BMC Vet Res. 2021 Apr 16;17(1):169
pubmed: 33863335
Vet Surg. 2021 Feb;50(2):410-417
pubmed: 33242227
J Vet Pharmacol Ther. 2015 Feb;38(1):24-34
pubmed: 25073816
N Z Vet J. 2017 Jan;65(1):14-18
pubmed: 27643584
Vet Anaesth Analg. 2017 Sep;44(5):1128-1138
pubmed: 29037800
Vet Anaesth Analg. 2014 Jul;41(4):335-45
pubmed: 24815750
Eur J Clin Pharmacol. 2018 Aug;74(8):1047-1054
pubmed: 29666901
J Opioid Manag. 2008 Jul-Aug;4(4):187-91
pubmed: 18837201
J Vet Pharmacol Ther. 2020 Jul;43(4):369-376
pubmed: 32166760
Vet Clin North Am Equine Pract. 2013 Apr;29(1):223-42
pubmed: 23498055
Vet Anaesth Analg. 2010 Jul;37(4):311-21
pubmed: 20636563
Vet Anaesth Analg. 2002 Oct;29(4):159-170
pubmed: 28404360
J Vet Pharmacol Ther. 2015 Aug;38(4):365-74
pubmed: 25484250
Equine Vet J. 2005 Jan;37(1):60-4
pubmed: 15651736
Vet Anaesth Analg. 2019 Sep;46(5):627-635
pubmed: 31395482
J Vet Pharmacol Ther. 2004 Dec;27(6):415-25
pubmed: 15601437
Vet Clin North Am Equine Pract. 2013 Apr;29(1):89-122
pubmed: 23498047
J Vet Pharmacol Ther. 2019 Jul;42(4):392-400
pubmed: 31197847
J Pharmacokinet Biopharm. 1978 Apr;6(2):165-75
pubmed: 671222
PLoS One. 2017 Apr 26;12(4):e0176443
pubmed: 28445495
BMC Vet Res. 2020 Nov 11;16(1):436
pubmed: 33176781
J Vet Pharmacol Ther. 2015 Feb;38(1):93-6
pubmed: 25229603
Vet Anaesth Analg. 2016 Jul;43(4):412-23
pubmed: 26488527
J Vet Pharmacol Ther. 2018 Apr;41(2):205-217
pubmed: 29226340
BMC Vet Res. 2022 Jul 11;18(1):269
pubmed: 35818051
J Vet Pharmacol Ther. 2021 Jul;44(4):533-543
pubmed: 33576078
Vet Anaesth Analg. 2016 May;43(3):242-55
pubmed: 26970940
Vet Anaesth Analg. 2010 Jan;37(1):48-56
pubmed: 20017819
Res Vet Sci. 2013 Dec;95(3):1186-94
pubmed: 24148870
J Vet Pharmacol Ther. 2015 Feb;38(1):15-23
pubmed: 25066475