Unveiling P. vivax invasion pathways in Duffy-negative individuals.
Duffy antigen receptor for chemokines
Duffy-negativity
Plasmodium vivax
Sub-Saharan Africa
erythropoiesis
invasion pathways
malaria
Journal
Cell host & microbe
ISSN: 1934-6069
Titre abrégé: Cell Host Microbe
Pays: United States
ID NLM: 101302316
Informations de publication
Date de publication:
13 Dec 2023
13 Dec 2023
Historique:
received:
06
06
2023
revised:
01
10
2023
accepted:
08
11
2023
pubmed:
7
12
2023
medline:
7
12
2023
entrez:
6
12
2023
Statut:
ppublish
Résumé
Vivax malaria has long been thought to be absent from sub-Saharan Africa owing to the high proportion of individuals lacking the Duffy antigen receptor for chemokines (DARC) in their erythrocytes. The interaction between P. vivax Duffy-binding protein (PvDBP) and DARC is assumed to be the main pathway used by merozoites to invade reticulocytes. However, the increasing number of reports of vivax malaria cases in genotypically Duffy-negative (DN) individuals has raised questions regarding the P. vivax invasion pathway(s). Here, we show that a subset of DN erythroblasts transiently express DARC during terminal erythroid differentiation and that P. vivax merozoites, irrespective of their origin, can invade DARC+ DN erythroblasts. These findings reveal that a large number of DN individuals may represent a silent reservoir of deep P. vivax infections at the sites of active erythropoiesis with low or no parasitemia, and it may represent an underestimated biological problem with potential clinical consequences in sub-Saharan Africa.
Identifiants
pubmed: 38056460
pii: S1931-3128(23)00457-2
doi: 10.1016/j.chom.2023.11.007
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2080-2092.e5Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.