Planar Chiral Rhodium Complex Based on the Tetrahydrofluorenyl Core for Enantioselective Catalysis.
Journal
Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393
Informations de publication
Date de publication:
05 Dec 2023
05 Dec 2023
Historique:
medline:
6
12
2023
pubmed:
6
12
2023
entrez:
5
12
2023
Statut:
aheadofprint
Résumé
A simple four-step route to a chiral tetrahydrofluorenyl rhodium catalyst from naturally occurring (-)-α-pinene was developed. Our approach does not use multistep and time-consuming procedures such as chiral HPLC or diastereomeric resolution. The key to success lies in the face-selective coordination of rhodium to the sterically hindered tetrahydrofluorenyl ligand, giving only one diastereomeric complex. This catalyst proved to be highly efficient for asymmetric C-H annulation of aryl hydroxamates with alkenes (yield up to 95%, 91%
Identifiants
pubmed: 38051945
doi: 10.1021/acs.orglett.3c03726
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM