S-SCAM is essential for synapse formation.
neuronal morphology
scaffolding protein
spine
synapse formation
synaptic transmission
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2023
2023
Historique:
received:
08
03
2023
accepted:
02
10
2023
medline:
4
12
2023
pubmed:
4
12
2023
entrez:
4
12
2023
Statut:
epublish
Résumé
Synapse formation is critical for the wiring of neural circuits in the developing brain. The synaptic scaffolding protein S-SCAM/MAGI-2 has important roles in the assembly of signaling complexes at post-synaptic densities. However, the role of S-SCAM in establishing the entire synapse is not known. Here, we report significant effects of RNAi-induced S-SCAM knockdown on the number of synapses in early stages of network development
Identifiants
pubmed: 38045729
doi: 10.3389/fncel.2023.1182493
pmc: PMC10690602
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1182493Informations de copyright
Copyright © 2023 Wittenmayer, Petkova-Tuffy, Borgmeyer, Lee, Becker, Böning, Kügler, Rhee, Viotti and Dresbach.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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