A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
22 Nov 2023
22 Nov 2023
Historique:
medline:
4
12
2023
pubmed:
4
12
2023
entrez:
4
12
2023
Statut:
epublish
Résumé
Here we report the discovery of MED6-189, a new analogue of the kalihinol family of isocyanoterpene (ICT) natural products. MED6-189 is effective against drug-sensitive and-resistant Here we report the mode of action and mechanism of resistance of a pan-antimalarial agent, MED6-189, which disrupts apicoplast function and vesicular trafficking in
Identifiants
pubmed: 38045341
doi: 10.1101/2023.11.21.568162
pmc: PMC10690269
pii:
doi:
Types de publication
Preprint
Langues
eng