Topical Insulin Application in the Management of Resistant Leg Ulcers in a Patient With Prolidase Deficiency: A Case Report.
insulin
leg ulcer
prolidase deficiency
topical treatment
treatment
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
accepted:
25
10
2023
medline:
29
11
2023
pubmed:
29
11
2023
entrez:
29
11
2023
Statut:
epublish
Résumé
Leg ulcers are a significant cause of morbidity and mortality and can be caused by vascular, neuropathic, infectious, and traumatic factors, as well as rare metabolic diseases like prolidase deficiency. Despite various wound care methods and systemic treatments, managing ulcers can be challenging. This case presents a male patient with prolidase deficiency for 35 years whose leg ulcers were resistant to standard treatments such as wound dressings, topical treatments, and hyperbaric oxygen therapy. Considering the ulcers' resistant nature, we applied topical insulin to ulcers as an add-on therapy and observed clinical improvement. In this case, we want to emphasize the potential of insulin as a supplementary treatment agent in prolidase deficiency-induced ulcer treatment.
Identifiants
pubmed: 38021973
doi: 10.7759/cureus.47672
pmc: PMC10672400
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e47672Informations de copyright
Copyright © 2023, Edek et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Int J Dermatol. 2002 Jan;41(1):45-8
pubmed: 11895514
Int J Dermatol. 2004 Sep;43(9):684-6
pubmed: 15357754
BMC Cell Biol. 2009 Jan 12;10:1
pubmed: 19134226
J Am Acad Dermatol. 2010 Jun;62(6):1031-4
pubmed: 20466176
Can J Ophthalmol. 2020 Oct;55(5):e170-e172
pubmed: 32416928
Int J Low Extrem Wounds. 2016 Mar;15(1):86-91
pubmed: 26637345
Arch Dermatol Res. 2016 Dec;308(10):677-694
pubmed: 27655635
Biol Open. 2018 Jan 17;7(1):
pubmed: 29101099
J Am Acad Dermatol. 2021 Nov;85(5):e271-e272
pubmed: 32526324
J Investig Clin Dent. 2019 Nov;10(4):e12437
pubmed: 31350870
Wound Repair Regen. 2012 May-Jun;20(3):425-34
pubmed: 22564234
Handb Exp Pharmacol. 2010;(195):209-26
pubmed: 20020367
Med Clin North Am. 2021 Jul;105(4):663-679
pubmed: 34059244
Cureus. 2023 Jun 1;15(6):e39822
pubmed: 37397672