One node among many: sevoflurane-induced hypnosis and the challenge of an integrative network-level view of anaesthetic action.
anaesthetic networks
chemogenetic
fibre photometry
hypnosis
optogenetic
pedunculopontine tegmentum
sleep
unconsciousness
Journal
British journal of anaesthesia
ISSN: 1471-6771
Titre abrégé: Br J Anaesth
Pays: England
ID NLM: 0372541
Informations de publication
Date de publication:
23 Nov 2023
23 Nov 2023
Historique:
received:
21
09
2023
revised:
30
10
2023
accepted:
01
11
2023
medline:
25
11
2023
pubmed:
25
11
2023
entrez:
24
11
2023
Statut:
aheadofprint
Résumé
Building on their known ability to influence sleep and arousal, Li and colleagues show that modulating the activity of glutamatergic pedunculopontine tegmental neurones also alters sevoflurane-induced hypnosis. This finding adds support for the shared sleep-anaesthesia circuit hypothesis. However, the expanding recognition of many neuronal clusters capable of modulating anaesthetic hypnosis raises the question of how disparate and anatomically distant sites ultimately interact to coordinate global changes in the state of the brain. Understanding how these individual sites work in concert to disrupt cognition and behaviour is the next challenge for anaesthetic mechanisms research.
Identifiants
pubmed: 38000931
pii: S0007-0912(23)00620-7
doi: 10.1016/j.bja.2023.11.002
pii:
doi:
Types de publication
Editorial
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2023 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.