Comparing ethanol lock therapy versus vancomycin lock in a salvation strategy for totally implantable vascular access device infections due to coagulase-negative staphylococci (the ETHALOCK study): a prospective double-blind randomized clinical trial.

Central venous catheter infection Coagulase-negative staphylococci Ethanol Lock solution Totally implantable vascular access device Vancomycin

Journal

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
ISSN: 1435-4373
Titre abrégé: Eur J Clin Microbiol Infect Dis
Pays: Germany
ID NLM: 8804297

Informations de publication

Date de publication:
23 Nov 2023
Historique:
received: 20 04 2023
accepted: 06 11 2023
medline: 23 11 2023
pubmed: 23 11 2023
entrez: 22 11 2023
Statut: aheadofprint

Résumé

Little is known about efficacy and safety of ethanol lock therapy (ELT) to treat totally implantable venous access device (TIVAD) infections. The objective of this trial was to evaluate the effectiveness and safety profile of a local treatment with ELT without removal for TIVAD infection due to coagulase-negative staphylococci. We performed a prospective, multicenter, double-blind, randomized clinical trial comparing the efficacy of 40% ELT versus vancomycin lock therapy (VLT) in TIVAD infections due to coagulase-negative staphylococci, complicated or not by bloodstream infection. Thirty-one patients were assigned to the ELT group and 30 to the VLT arm. Concomitant bacteremia was present in 41 patients (67.2%). Treatment success was 58.1 % (18 of 31) for the ELT arm and 46.7% (14 of 30) for the VLT arm (p = 0.37). The overall treatment success was 52.5% (32). The risk of treatment failure due to uncontrolled infections, superinfections, and mechanical complications did not differ significantly between participants receiving ELT (13 out of 31 [42%]) and those receiving VLT (16 out of 30 [53%]) with a hazard ratio of 0.70 (p = 0.343; 95% CI [0.34-1.46], Cox model). Catheter malfunctions were significantly more frequent in the ELT arm (11 patients versus 2 in the VLT group, p = 0.01). We found an overall high rate of treatment failure that did not differ between the ELT arm and the VLT arm. TIVAD removal must be prioritized to prevent complications (uncontrolled infections, superinfections, and catheter malfunctions) except in exceptional situations.

Identifiants

pubmed: 37993679
doi: 10.1007/s10096-023-04702-w
pii: 10.1007/s10096-023-04702-w
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Auteurs

Olivier Lesens (O)

Infectious and Tropical Diseases Department, Centre Hospitalier de Cayenne Andrée Rosemon, Cayenne, French Guiana. olivier.lesens@ch-cayenne.fr.
Centre d'Investigation Clinique (CIC INSERM 1424), Centre Hospitalier de Cayenne Andrée Rosemon, Cayenne, French Guiana. olivier.lesens@ch-cayenne.fr.
Infectious and Tropical Diseases Department, Clermont-Ferrand University Hospital Center, Reference Center for Osteoarticular Infections, Regional Reference Center for Tick-Based Vector Diseases, Genome and Environment Microorganisms Laboratory, Clermont Auvergne University, Clermont-Ferrand, France. olivier.lesens@ch-cayenne.fr.

Emmanuel Forestier (E)

Infectious Disease Department, Metropole Savoie Hospital Center, Chambery, France.

Elisabeth Botelho-Nevers (E)

Infectious Diseases Department, Saint-Etienne University Hospital Center, Saint-Etienne, France.

Patricia Pavese (P)

Infectious Disease Department, Grenoble University Hospital Center, Grenoble, France.

Gary David (G)

Infectious Disease Department, Villefranche sur Saône Hospital Center, Villefranche sur Saône, France.

Bertrand Nougarede (B)

Jean Perrin Comprehensive Cancer Center, Clermont-Ferrand, France.

Violaine Corbin (V)

Infectious and Tropical Diseases Department, Clermont-Ferrand University Hospital Center, Reference Center for Osteoarticular Infections, Regional Reference Center for Tick-Based Vector Diseases, Genome and Environment Microorganisms Laboratory, Clermont Auvergne University, Clermont-Ferrand, France.

Bruno Pereira (B)

Clinical Research Direction, Clermont-Ferrand University Hospital Center, Clermont-Ferrand, France.

Claire Aumeran (C)

Infection Control Department, 3IHP, CHU Clermont-Ferrand, 63000, Clermont-Ferrand, France.

Léo Sauvat (L)

Infection Control Department, 3IHP, CHU Clermont-Ferrand, 63000, Clermont-Ferrand, France.

Classifications MeSH