Time course evaluation of collagen type IV in Pectoralis major muscles of broiler chickens selected for different growth-rates.
breast meat abnormality
broiler
collagen type IV
genotype
growth-rate
Journal
Poultry science
ISSN: 1525-3171
Titre abrégé: Poult Sci
Pays: England
ID NLM: 0401150
Informations de publication
Date de publication:
11 Oct 2023
11 Oct 2023
Historique:
received:
28
07
2023
revised:
25
09
2023
accepted:
06
10
2023
medline:
7
11
2023
pubmed:
7
11
2023
entrez:
6
11
2023
Statut:
aheadofprint
Résumé
Collagen type IV (COL4) is one of the major components of animals' and humans' basement membranes of several tissues, such as skeletal muscles and vascular endothelia. Alterations in COL4 assembly and secretion are associated to muscular disorders in humans and animals among which growth-related abnormalities such as white striping and wooden breast affecting Pectoralis major muscles (PMs) in modern fast-growing (FG) chickens. Considering the high prevalence of these myopathies in FG broilers and that a worsening is observed as the bird slaughter age is increased, the present study was intended to evaluate the distribution and the expression level of COL4 protein and its coding genes in PMs of FG broilers at different stages of muscle development (i.e., 7, 14, 21, 28, 35, and 42 d of age). Medium-growing (MG) chickens have been considered as the control group in consideration of the lower selection pressure on breast muscle growth rate and hypertrophy. Briefly, 5 PM/sampling time/genotype were selected for western blot, immunohistochemistry (IHC), and gene expression analyses. The normalized expression levels of COL4 coding genes showed an overexpression of COL4A2 in FG than MG at d 28, as well as a significant decrease in its expression over their rearing period. Overall, results obtained through the gene expression analysis suggested that selection for the hypertrophic growth of FG broilers may have led to an altered regulation of fibroblast proliferation and COL4 synthesis. Moreover, western blot and IHC analyses suggested an altered secretion and/or degradation of COL4 protein in FG broilers, as evidenced by the fluctuating trend of 2 bands observed in FG over time. In view of the above, the present research supports the evidence about a potential aberrant synthesis and/or degradation of COL4 and corroborates the hypothesis regarding a likely involvement of COL4 in the series of events underlying the growth-related abnormalities in modern FG broilers.
Identifiants
pubmed: 37931400
pii: S0032-5791(23)00698-3
doi: 10.1016/j.psj.2023.103179
pmc: PMC10652102
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
103179Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
DISCLOSURES The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Comp Biochem Physiol A Mol Integr Physiol. 2022 Nov;273:111296
pubmed: 35973649
J Pharmacol Sci. 2019 Feb;139(2):59-64
pubmed: 30580971
Poult Sci. 2021 Jun;100(6):101180
pubmed: 33975044
PLoS One. 2021 Jan 4;16(1):e0243983
pubmed: 33395447
Food Res Int. 2018 May;107:206-215
pubmed: 29580479
Acta Physiol (Oxf). 2019 Aug;226(4):e13320
pubmed: 31152472
Hum Mol Genet. 2012 Oct 15;21(R1):R97-110
pubmed: 22914737
Proc Natl Acad Sci U S A. 1984 Dec;81(23):7343-7
pubmed: 6209713
PLoS One. 2016 Apr 20;11(4):e0153750
pubmed: 27097013
Genome Biol. 2002 Jun 18;3(7):RESEARCH0034
pubmed: 12184808
Neurobiol Dis. 2017 Apr;100:52-61
pubmed: 28057519
J Comp Pathol. 2018 May;161:1-10
pubmed: 30173852
Circ Res. 2002 Apr 19;90(7):784-91
pubmed: 11964371
Reprod Sci. 2012 Oct;19(10):1030-40
pubmed: 22573493
Dev Biol. 2017 Nov 15;431(2):124-133
pubmed: 28982537
Genet Med. 2015 Nov;17(11):843-53
pubmed: 25719457
Avian Pathol. 2019 Feb;48(1):1-3
pubmed: 30246553
Am J Physiol Cell Physiol. 2023 Mar 1;324(3):C679-C693
pubmed: 36717103
Anal Biochem. 2013 Feb 15;433(2):105-11
pubmed: 23085117
Int J Mol Sci. 2019 Oct 16;20(20):
pubmed: 31623094
Essays Biochem. 2019 Sep 13;63(3):297-312
pubmed: 31387942
Circulation. 2015 May 5;131(18):1555-65
pubmed: 25753534
Cereb Circ Cogn Behav. 2022 Mar 24;3:100140
pubmed: 36324412
Annu Rev Anim Biosci. 2019 Feb 15;7:289-308
pubmed: 30256651
Front Physiol. 2022 Sep 05;13:970034
pubmed: 36134328
Mol Med Rep. 2020 Aug;22(2):661-670
pubmed: 32467996
Poult Sci. 2020 Jan;99(1):620-628
pubmed: 32416850
Hum Mol Genet. 2014 Apr 1;23(7):1709-22
pubmed: 24203695
Sci Rep. 2019 Oct 17;9(1):14905
pubmed: 31624339
Poult Sci. 2013 Feb;92(2):331-8
pubmed: 23300297
Poult Sci. 2021 Dec;100(12):101496
pubmed: 34695627
Development. 2004 Apr;131(7):1619-28
pubmed: 14998921
PLoS One. 2018 Dec 5;13(12):e0207346
pubmed: 30517117
Am J Hum Genet. 2019 May 2;104(5):847-860
pubmed: 31051113
J Biol Chem. 1982 May 10;257(9):5239-45
pubmed: 6802849
Nucleic Acids Res. 2012 Aug;40(15):e115
pubmed: 22730293
Front Physiol. 2020 May 07;11:461
pubmed: 32457657
Compr Rev Food Sci Food Saf. 2019 Mar;18(2):565-583
pubmed: 33336940
Avian Pathol. 2017 Dec;46(6):623-643
pubmed: 28609139
Sci Rep. 2016 Jan 27;6:18602
pubmed: 26813606
Front Physiol. 2020 Mar 13;11:169
pubmed: 32231585
Lab Invest. 2015 Aug;95(8):872-85
pubmed: 26006016
J Biol Chem. 2021 Jan-Jun;296:100541
pubmed: 33722606
Poult Sci. 2021 Mar;100(3):100945
pubmed: 33652536
BMC Genomics. 2015 May 21;16:399
pubmed: 25994290
Biotechnol Lett. 2004 Mar;26(6):509-15
pubmed: 15127793
Am J Respir Cell Mol Biol. 2011 Aug;45(2):287-94
pubmed: 20971881
Sci Rep. 2021 Jan 19;11(1):1776
pubmed: 33469097
Front Physiol. 2020 Jan 17;10:1581
pubmed: 32009982
Vet Pathol. 2017 Jan;54(1):119-128
pubmed: 27511311
Sci Rep. 2023 Mar 23;13(1):4747
pubmed: 36959331
Avian Dis. 2017 Dec;61(4):481-490
pubmed: 29337623
J Biol Chem. 2004 Apr 2;279(14):14201-6
pubmed: 14732718
Front Physiol. 2022 Jul 08;13:936768
pubmed: 35874513
Poult Sci. 2021 Mar;100(3):100804
pubmed: 33516474
Exp Cell Res. 2003 Jan 15;282(2):90-100
pubmed: 12531695
Int J Mol Sci. 2022 Jun 28;23(13):
pubmed: 35806204
Am J Pathol. 2017 Mar;187(3):505-516
pubmed: 28056338
PLoS One. 2012;7(11):e48974
pubmed: 23139829
Acta Physiol (Oxf). 2019 Aug;226(4):e13278
pubmed: 30943315
Atherosclerosis. 2015 Oct;242(2):543-52
pubmed: 26310581
Am J Physiol Renal Physiol. 2017 Sep 1;313(3):F596-F602
pubmed: 28424209
Front Pharmacol. 2022 Mar 24;13:860588
pubmed: 35401211
J Mol Cell Cardiol. 2018 Aug;121:36-50
pubmed: 29913136
Poult Sci. 2016 Dec 1;95(12):2771-2785
pubmed: 27591279
PLoS One. 2012;7(12):e51044
pubmed: 23227231