Estimating gene-level false discovery probability improves eQTL statistical fine-mapping precision.

Journal

NAR genomics and bioinformatics
ISSN: 2631-9268
Titre abrégé: NAR Genom Bioinform
Pays: England
ID NLM: 101756213

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 24 03 2023
revised: 10 08 2023
accepted: 25 09 2023
medline: 2 11 2023
pubmed: 2 11 2023
entrez: 2 11 2023
Statut: epublish

Résumé

Statistical fine-mapping prioritizes putative causal variants from a large number of candidate variants, and is widely used in expression quantitative loci (eQTLs) studies. In eQTL fine-mapping, the existence of causal variants for gene expression is not guaranteed, since the genetic heritability of gene expression explained by nearby (

Identifiants

DOI: 10.1093/nargab/lqad090 PMID: 37915762 PMC: PMC10616627
pubmed: 37915762
doi: 10.1093/nargab/lqad090
pii: lqad090
pmc: PMC10616627
doi:

Types de publication

Journal Article

Langues

eng

Pagination

lqad090

Informations de copyright

© The Author(s) 2023. Published by Oxford University Press on behalf of NAR Genomics and Bioinformatics.

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Auteurs

Qingbo S Wang (QS)

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.
Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, 565-0871, Japan.
Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, 113-0033, Japan.
ORCID: 0000-0002-9110-5830

Ryuya Edahiro (R)

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.
Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.

Ho Namkoong (H)

Department of Infectious Diseases, Keio University School of Medicine, Tokyo, 160-8582, Japan.
ORCID: 0000-0001-6181-4284

Takanori Hasegawa (T)

M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, 113-8510, Japan.

Yuya Shirai (Y)

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.
Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.

Kyuto Sonehara (K)

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.
Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, 113-0033, Japan.
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, 565-0871, Japan.

Atsushi Kumanogoh (A)

Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, 565-0871, Japan.
Department of Immunopathology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, 565-0871, Japan.
Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, 565-0871, Japan.

Makoto Ishii (M)

Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, 65 tsurumai, Showa-ku, Nagoya, 466-8550, Japan.
ORCID: 0000-0003-4396-1664

Ryuji Koike (R)

Health Science Research and Development Center (HeRD), Tokyo Medical and Dental University, Tokyo, 113-8510, Japan.

Akinori Kimura (A)

Institute of Research, Tokyo Medical and Dental University, Tokyo, 113-8510, Japan.

Seiya Imoto (S)

Division of Health Medical Intelligence, Human Genome Center, the Institute of Medical Science, the University of Tokyo, Tokyo, 108-8639, Japan.
ORCID: 0000-0002-2989-308X

Satoru Miyano (S)

M&D Data Science Center, Tokyo Medical and Dental University, Tokyo, 113-8510, Japan.

Seishi Ogawa (S)

Department of Pathology and Tumor Biology, Kyoto University, Kyoto, 606-8315, Japan.
Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, 606-8303, Japan.
Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Stockholm, 171 77, Sweden.
ORCID: 0000-0002-7778-5374

Takanori Kanai (T)

Division of Gastroenterology and Hepatology, Department of Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Koichi Fukunaga (K)

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Yukinori Okada (Y)

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan.
Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, 565-0871, Japan.
Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Tokyo, 113-0033, Japan.
Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, 565-0871, Japan.
Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, 565-0871, Japan.
Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, 230-0045, Japan.
ORCID: 0000-0002-0311-8472

Classifications MeSH