Retrospective Evaluation of the Results of Low-Dose Intravenous Thrombolytic Therapy in Acute Ischemic Stroke.
Intracranial hemorrhage
ischemic stroke
thrombolytic therapy
Journal
Sisli Etfal Hastanesi tip bulteni
ISSN: 1302-7123
Titre abrégé: Sisli Etfal Hastan Tip Bul
Pays: Turkey
ID NLM: 9424130
Informations de publication
Date de publication:
2023
2023
Historique:
received:
01
11
2022
revised:
01
04
2023
accepted:
05
04
2023
medline:
30
10
2023
pubmed:
30
10
2023
entrez:
30
10
2023
Statut:
epublish
Résumé
This study aimed to investigate the clinical data of patients with acute ischemic stroke who received low-dose intravenous (IV) thrombolytic therapy (0.9 mg/kg; maximum 50 mg) for various reasons, compare the obtained results with those of patients who received standard-dose thrombolytic therapy, and discuss them in light of the literature. Patients who received IV thrombolytic therapy within 4.5 h of symptom onset between January 2015 and June 2018 were retrospectively reviewed. Patients were divided into the low-dose group (0.9 mg/kg; max. 50 mg) and the standard-dose group (0.9 mg/kg; max 90 mg) according to the thrombolytic therapy dose, after which demographic data and clinical results were analyzed. A total of 109 patients receiving thrombolytic therapy (19 patients in the low-dose group and 90 patients in the standard-dose group) were included in the study. There was no significant difference between the two groups in terms of good outcome rates (47.4% vs. 52.2%). There was no statistically significant difference in terms of symptomatic and asymptomatic intracerebral hemorrhage rates. Our study showed similar efficacy and safety for low-dose IV thrombolytic therapy compared with standard-dose IV thrombolytic therapy administered within 4.5 h of symptom onset in patients with acute ischemic stroke.
Identifiants
pubmed: 37900337
doi: 10.14744/SEMB.2023.51437
pii: SEMB-57-359
pmc: PMC10600607
doi:
Types de publication
Journal Article
Langues
eng
Pagination
359-366Informations de copyright
©Copyright 2023 by The Medical Bulletin of Sisli Etfal Hospital.
Déclaration de conflit d'intérêts
None declared.
Références
Stroke. 2006 Jul;37(7):1810-5
pubmed: 16763187
Lancet. 1991 Jun 22;337(8756):1521-6
pubmed: 1675378
J Vasc Interv Radiol. 2019 Feb;30(2):134-140
pubmed: 30717945
J Neuroimaging. 2011 Apr;21(2):113-20
pubmed: 19909396
Medicine (Baltimore). 2017 Dec;96(51):e9435
pubmed: 29390574
Lancet. 2014 Nov 29;384(9958):1929-35
pubmed: 25106063
J Clin Neurosci. 2009 Oct;16(10):1276-8
pubmed: 19570685
Sci Rep. 2016 Aug 11;6:31344
pubmed: 27510959
J Stroke Cerebrovasc Dis. 2013 Jul;22(5):690-3
pubmed: 23111010
BMC Neurol. 2021 Nov 9;21(1):434
pubmed: 34753432
CNS Neurosci Ther. 2015 Aug;21(8):657-61
pubmed: 26096605
J Stroke Cerebrovasc Dis. 2016 Oct;25(10):2543-8
pubmed: 27444521
Stroke. 2015 Sep;46(9):2541-8
pubmed: 26243232
J Stroke Cerebrovasc Dis. 2018 Dec;27(12):3587-3590
pubmed: 30217636
Circulation. 2017 Mar 14;135(11):1024-1035
pubmed: 28119380
Stroke. 2009 Nov;40(11):3591-5
pubmed: 19762694
Drug Des Devel Ther. 2020 Jan 17;14:257-263
pubmed: 32021109
Lancet. 2020 Jul 11;396(10244):129-142
pubmed: 32653056
Int J Stroke. 2015 Jul;10(5):778-88
pubmed: 25832995
Acta Neurol Scand. 2018 Mar;137(3):347-355
pubmed: 29218699
Stroke. 2016 Feb;47(2):581-641
pubmed: 26696642
Clin Neurol Neurosurg. 2007 Sep;109(7):567-70
pubmed: 17573188
Postgrad Med. 2000 May 15;107(6):85-6, 89-93
pubmed: 10865869
Neurologia (Engl Ed). 2022 Mar;37(2):130-135
pubmed: 35279226
Cerebrovasc Dis. 2011;31(2):123-9
pubmed: 21088392
N Engl J Med. 1995 Dec 14;333(24):1581-7
pubmed: 7477192
J Neurol Sci. 2019 Apr 15;399:76-81
pubmed: 30780072
Int J Stroke. 2014 Dec;9(8):1117-24
pubmed: 25088843
Ann Indian Acad Neurol. 2018 Jul-Sep;21(3):214-219
pubmed: 30258265
Stroke. 2018 Mar;49(3):e46-e110
pubmed: 29367334
Postgrad Med. 1998 Apr;103(4):221-4, 229-31
pubmed: 9553597
JAMA Neurol. 2014 Sep;71(9):1181-5
pubmed: 25069522
J Stroke Cerebrovasc Dis. 2018 Feb;27(2):381-390
pubmed: 29111341
Expert Rev Neurother. 2013 Aug;13(8):895-902
pubmed: 23965163
Stroke. 2010 Sep;41(9):1984-9
pubmed: 20651262
Stroke. 2014 Aug;45(8):2354-8
pubmed: 25013020
Stroke. 2017 Sep;48(9):2605-2609
pubmed: 28739832
N Engl J Med. 2016 Jun 16;374(24):2313-23
pubmed: 27161018