The Impact of Neurotransmitters on the Neurobiology of Neurodegenerative Diseases.
Dopamine
HIV-1 Associated Neurocognitive Disorders
neurodegenerative diseases
neurotransmitters
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Oct 2023
19 Oct 2023
Historique:
received:
26
09
2023
revised:
16
10
2023
accepted:
17
10
2023
medline:
30
10
2023
pubmed:
28
10
2023
entrez:
28
10
2023
Statut:
epublish
Résumé
Neurodegenerative diseases affect millions of people worldwide. Neurodegenerative diseases result from progressive damage to nerve cells in the brain or peripheral nervous system connections that are essential for cognition, coordination, strength, sensation, and mobility. Dysfunction of these brain and nerve functions is associated with Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and motor neuron disease. In addition to these, 50% of people living with HIV develop a spectrum of cognitive, motor, and/or mood problems collectively referred to as HIV-Associated Neurocognitive Disorders (HAND) despite the widespread use of a combination of antiretroviral therapies. Neuroinflammation and neurotransmitter systems have a pathological correlation and play a critical role in developing neurodegenerative diseases. Each of these diseases has a unique pattern of dysregulation of the neurotransmitter system, which has been attributed to different forms of cell-specific neuronal loss. In this review, we will focus on a discussion of the regulation of dopaminergic and cholinergic systems, which are more commonly disturbed in neurodegenerative disorders. Additionally, we will provide evidence for the hypothesis that disturbances in neurotransmission contribute to the neuronal loss observed in neurodegenerative disorders. Further, we will highlight the critical role of dopamine as a mediator of neuronal injury and loss in the context of NeuroHIV. This review will highlight the need to further investigate neurotransmission systems for their role in the etiology of neurodegenerative disorders.
Identifiants
pubmed: 37895020
pii: ijms242015340
doi: 10.3390/ijms242015340
pmc: PMC10607327
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : DA047924
Pays : United States
Organisme : NIH HHS
ID : DA035714
Pays : United States
Organisme : NIH HHS
ID : DA057866
Pays : United States
Organisme : NIH HHS
ID : DA057163
Pays : United States
Références
EMBO J. 2007 Apr 18;26(8):2127-36
pubmed: 17380124
Curr Opin Neurobiol. 2020 Aug;63:122-130
pubmed: 32408142
J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9
pubmed: 24833586
PLoS One. 2008;3(11):e3731
pubmed: 19009018
Neurology. 2013 May 7;80(19):1778-83
pubmed: 23390181
J Neurochem. 1999 Dec;73(6):2406-14
pubmed: 10582600
J Pharmacol Exp Ther. 2019 Nov;371(2):526-543
pubmed: 31413138
J Alzheimers Dis. 2011;26(4):755-66
pubmed: 21743130
Acta Neuropathol. 2023 Feb;145(2):175-195
pubmed: 36481964
Curr Opin Immunol. 2021 Feb;68:116-124
pubmed: 33181351
Curr HIV Res. 2015;13(1):21-42
pubmed: 25613135
J Neuroimmune Pharmacol. 2019 Mar;14(1):134-156
pubmed: 30519866
Biochem Biophys Res Commun. 2003 May 9;304(3):463-70
pubmed: 12729580
Pharmacol Rev. 2015 Oct;67(4):1005-24
pubmed: 26408528
J Neurosci Res. 1991 Mar;28(3):406-9
pubmed: 1856886
RSC Med Chem. 2022 Sep 5;13(11):1410-1419
pubmed: 36439982
Neuroreport. 1996 Mar 22;7(4):910-2
pubmed: 8724671
Nat Rev Neurol. 2016 Apr;12(4):234-48
pubmed: 26965674
Curr Opin Neurobiol. 2022 Aug;75:102575
pubmed: 35691251
Cell Mol Life Sci. 2021 May;78(9):4283-4303
pubmed: 33585975
J Biol Chem. 2000 Feb 25;275(8):5626-32
pubmed: 10681545
Met Ions Life Sci. 2013;12:119-68
pubmed: 23595672
J Neurovirol. 2009 May;15(3):257-74
pubmed: 19499455
Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2271-6
pubmed: 20133871
Extracell Vesicles Circ Nucl Acids. 2022;3(2):133-149
pubmed: 36812097
Curr Pharm Des. 2006;12(6):677-84
pubmed: 16472157
Exp Neurol. 2017 Sep;295:176-183
pubmed: 28579325
Brain Behav Immun. 2019 Nov;82:239-252
pubmed: 31470080
Front Neurol. 2019 Mar 26;10:285
pubmed: 30972014
Traffic. 2008 Sep;9(9):1414-24
pubmed: 18445120
Neurology. 1993 Oct;43(10):2099-104
pubmed: 8413973
Cell Mol Immunol. 2020 Mar;17(3):283-299
pubmed: 31320730
J Pharmacol Exp Ther. 2023 Feb;384(2):306-314
pubmed: 36456195
Cells. 2020 Sep 08;9(9):
pubmed: 32911641
Trends Pharmacol Sci. 2013 Sep;34(9):489-96
pubmed: 23968642
J Biol Chem. 2005 Dec 9;280(49):40442-9
pubmed: 16204245
Front Public Health. 2021 Dec 07;9:776847
pubmed: 34950630
Biochem Pharmacol. 2013 Oct 15;86(8):1063-73
pubmed: 23830821
Front Aging Neurosci. 2016 Feb 23;8:31
pubmed: 26941642
J Neurosci. 2014 Sep 17;34(38):12850-64
pubmed: 25232120
Curr HIV Res. 2012 Jul;10(5):369-83
pubmed: 22591361
Neurochem Int. 2002 Nov;41(5):291-9
pubmed: 12176069
Cell Death Discov. 2023 Feb 17;9(1):69
pubmed: 36801911
J Biol Chem. 2002 Jul 12;277(28):25178-86
pubmed: 11994276
Biochemistry. 1998 Sep 22;37(38):13400-10
pubmed: 9748347
J Neurovirol. 2009 Sep;15(5-6):401-10
pubmed: 20175694
Adv Pharmacol. 2014;69:71-106
pubmed: 24484975
Oncogene. 2008 Oct 27;27(50):6407-18
pubmed: 18955969
ACS Chem Neurosci. 2019 Jun 19;10(6):2707-2717
pubmed: 30965003
Am J Pathol. 2003 May;162(5):1693-707
pubmed: 12707054
Aging Cell. 2007 Jun;6(3):319-25
pubmed: 17517041
Neurology. 2007 Oct 30;69(18):1789-99
pubmed: 17914061
AIDS. 2019 Dec 1;33 Suppl 2:S145-S157
pubmed: 31789815
J Biol Chem. 2016 Sep 30;291(40):20849-20857
pubmed: 27462077
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13588-93
pubmed: 23898208
Brain Behav Immun. 2017 Oct;65:210-221
pubmed: 28495611
Neurochem Int. 2019 Jan;122:94-105
pubmed: 30465801
Drug Alcohol Depend. 2017 Sep 1;178:7-14
pubmed: 28623807
Physiol Rev. 2009 Jan;89(1):73-120
pubmed: 19126755
Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9977-82
pubmed: 24979780
Neurosignals. 2009;17(1):42-54
pubmed: 19212139
Int J Mol Sci. 2019 Nov 07;20(22):
pubmed: 31703453
J Neuroinflammation. 2022 Feb 26;19(1):56
pubmed: 35219323
J Prev Alzheimers Dis. 2021;8(3):313-321
pubmed: 34101789
Mol Aspects Med. 2013 Apr-Jun;34(2-3):360-72
pubmed: 23506877
Front Neurosci. 2018 Jun 26;12:419
pubmed: 29997470
J Neurol Neurosurg Psychiatry. 2020 Aug;91(8):795-808
pubmed: 32576618
Trends Biochem Sci. 2016 Dec;41(12):1012-1021
pubmed: 27669650
Brain Res. 2000 Oct 6;879(1-2):42-9
pubmed: 11011004
Neuropharmacology. 2005 Oct;49(5):638-45
pubmed: 15939443
J Neurochem. 2001 Aug;78(3):457-67
pubmed: 11483648
Traffic. 2008 Sep;9(9):1425-36
pubmed: 18507811
CNS Drugs. 2018 Dec;32(12):1131-1144
pubmed: 30306450
J Neurochem. 2007 Mar;100(5):1387-96
pubmed: 17217417
Curr Opin Pharmacol. 2010 Feb;10(1):93-9
pubmed: 19897420
Molecules. 2020 Dec 08;25(24):
pubmed: 33302541
J Neurovirol. 2011 Feb;17(1):26-40
pubmed: 21165787
ACS Chem Neurosci. 2015 Apr 15;6(4):658-665
pubmed: 25695767
Prog Neurobiol. 2012 Mar;96(3):304-21
pubmed: 22307060
Biochim Biophys Acta. 2009 May;1787(5):335-44
pubmed: 19268425
Front Mol Neurosci. 2020 Dec 03;13:610964
pubmed: 33343299
PLoS One. 2022 Sep 28;17(9):e0275182
pubmed: 36170295
Neuron. 2003 Jun 19;38(6):987-96
pubmed: 12818183
Biol Psychiatry. 1995 Jul 1;38(1):22-33
pubmed: 7548469
Curr Opin Pharmacol. 2017 Feb;32:56-70
pubmed: 27875804
Clin Chim Acta. 2021 Nov;522:114-126
pubmed: 34389279
Neuropsychopharmacology. 2018 May;43(6):1405-1414
pubmed: 29185481
J Acquir Immune Defic Syndr. 2002 Oct 1;31 Suppl 2:S55-61
pubmed: 12394783
Int Rev Neurobiol. 2007;82:339-56
pubmed: 17678970
PLoS One. 2011 Jan 27;6(1):e16350
pubmed: 21298009
J Biol Chem. 2003 Jun 13;278(24):22168-74
pubmed: 12682063
Front Neuroanat. 2020 Jun 04;14:26
pubmed: 32581728
Oxid Med Cell Longev. 2022 Jan 29;2022:2501279
pubmed: 35132346
AIDS. 1994 Jan;8(1):67-71
pubmed: 8011238
Neuron. 2017 Nov 1;96(3):651-666
pubmed: 29096078
J Neurovirol. 2020 Oct;26(5):664-675
pubmed: 32804309
J Neurosci. 2003 Jul 30;23(17):6810-8
pubmed: 12890775
Mol Membr Biol. 2008 May;25(4):279-92
pubmed: 18446614
Mol Pharmacol. 2011 Mar;79(3):520-32
pubmed: 21149640
Nat Rev Neurosci. 2020 Apr;21(4):213-229
pubmed: 32161339
Exp Neurol. 1998 Dec;154(2):276-88
pubmed: 9878167
Brain Res. 2010 Jan 8;1306:116-30
pubmed: 19815008
Biochem J. 2013 Mar 1;450(2):265-74
pubmed: 23410039
Int J Biochem Cell Biol. 2023 Apr;157:106387
pubmed: 36754161
Neuropharmacology. 2022 Dec 01;220:109239
pubmed: 36126727
Mol Cell Neurosci. 2019 Dec;101:103414
pubmed: 31655116
Cells. 2021 May 17;10(5):
pubmed: 34067760
Trends Pharmacol Sci. 2006 Jun;27(6):317-23
pubmed: 16678913
Cell Commun Signal. 2013 May 17;11(1):34
pubmed: 23683503
J Pharmacol Exp Ther. 2020 Aug;374(2):241-251
pubmed: 32461322
Pharmacol Ther. 2018 Mar;183:78-89
pubmed: 28987321
Cell Mol Neurobiol. 2019 Jan;39(1):31-59
pubmed: 30446950
J Pharmacol Exp Ther. 2009 Jun;329(3):1071-83
pubmed: 19325033
PLoS One. 2021 Mar 11;16(3):e0248309
pubmed: 33705493
J Immunol Res. 2016;2016:3969023
pubmed: 26885533
Front Aging Neurosci. 2022 Jun 10;14:879021
pubmed: 35754962
Appl Microbiol Biotechnol. 2020 Jul;104(14):6129-6140
pubmed: 32447438
Biochem Pharmacol. 2014 May 1;89(1):1-11
pubmed: 24486571
Physiol Rev. 2004 Jul;84(3):835-67
pubmed: 15269338
J Neurochem. 1999 Oct;73(4):1363-74
pubmed: 10501179
Front Physiol. 2017 Jan 20;8:5
pubmed: 28163686
Brain. 2004 Nov;127(Pt 11):2452-8
pubmed: 15319273
J Neural Transm (Vienna). 2010 Jun;117(6):699-705
pubmed: 20454983
Brain Res. 1995 Dec 24;705(1-2):168-76
pubmed: 8821747
Annu Rev Neurosci. 1997;20:125-56
pubmed: 9056710
Cell Calcium. 2006 Nov-Dec;40(5-6):553-60
pubmed: 17074387
Biochemistry. 2009 Feb 10;48(5):1067-76
pubmed: 19146407
Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):16046-51
pubmed: 15520385
J Neurosci. 1996 Jan 15;16(2):436-47
pubmed: 8551328
Sci Rep. 2018 May 23;8(1):8028
pubmed: 29795337
Int J Alzheimers Dis. 2022 Mar 9;2022:9343514
pubmed: 35308835
Cell Commun Signal. 2011 Sep 22;9:19
pubmed: 21939514
ACS Chem Neurosci. 2021 May 5;12(9):1519-1527
pubmed: 33886267
Synapse. 2006 Jan;59(1):51-60
pubmed: 16237680
J Med Chem. 2016 Dec 8;59(23):10676-10691
pubmed: 27933960
Int J Mol Sci. 2022 Jul 28;23(15):
pubmed: 35955494
Pharmacol Ther. 2018 Jun;186:152-167
pubmed: 29360540
Neuroscience. 2014 Feb 14;259:194-202
pubmed: 24321511
Mol Neurodegener. 2019 Aug 20;14(1):35
pubmed: 31488222
Front Mol Neurosci. 2019 Sep 25;12:230
pubmed: 31607863
Physiol Rev. 2022 Jan 1;102(1):209-268
pubmed: 34280054
Int J Mol Sci. 2020 Oct 09;21(20):
pubmed: 33050345
Int J Mol Sci. 2020 Mar 14;21(6):
pubmed: 32183332
Biochemistry. 2007 Sep 18;46(37):10484-97
pubmed: 17711354
Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):6479-84
pubmed: 24733892
Nature. 2017 Aug 24;548(7668):420-425
pubmed: 28813412
J Psychopharmacol. 2000;14(3):214-21
pubmed: 11106299
J Neural Transm (Vienna). 2013 Oct;120(10):1411-9
pubmed: 24057505
J Neurosci. 2002 Oct 15;22(20):8951-60
pubmed: 12388602
Int Immunopharmacol. 2019 Feb;67:458-464
pubmed: 30594776
Neurochem Int. 2020 Nov;140:104810
pubmed: 32768485
Trends Pharmacol Sci. 2019 Dec;40(12):1006-1020
pubmed: 31711626
Aging Dis. 2020 Oct 1;11(5):1291-1316
pubmed: 33014538
J Leukoc Biol. 1999 Apr;65(4):458-65
pubmed: 10204574
Neuron. 2022 Mar 16;110(6):935-966
pubmed: 35134347
Cereb Cortex. 2010 Aug;20(8):1974-84
pubmed: 20034999
Biochim Biophys Acta. 2006 May-Jun;1757(5-6):639-47
pubmed: 16678785
Neurosci Lett. 1995 Sep 15;197(3):215-8
pubmed: 8552302
Front Cell Neurosci. 2014 Aug 01;8:216
pubmed: 25136295
Oxid Med Cell Longev. 2019 Oct 7;2019:3462530
pubmed: 31687078
Eur J Pharmacol. 1999 Jan 15;365(1):27-34
pubmed: 9988119
Br J Pharmacol. 2001 Feb;132(4):950-8
pubmed: 11181437
Neuron. 2009 Apr 30;62(2):218-29
pubmed: 19409267
Curr Drug Targets. 2016;17(1):4-14
pubmed: 26028040
Neuropharmacology. 2020 Oct 15;177:108256
pubmed: 32738308