Targeted depletion of TRBV9
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
received:
22
06
2023
accepted:
26
09
2023
medline:
27
11
2023
pubmed:
24
10
2023
entrez:
23
10
2023
Statut:
ppublish
Résumé
Autoimmunity is intrinsically driven by memory T and B cell clones inappropriately targeted at self-antigens. Selective depletion or suppression of self-reactive T cells remains a holy grail of autoimmune therapy, but disease-associated T cell receptors (TCRs) and cognate antigenic epitopes remained elusive. A TRBV9-containing CD8
Identifiants
pubmed: 37872223
doi: 10.1038/s41591-023-02613-z
pii: 10.1038/s41591-023-02613-z
pmc: PMC10667094
doi:
Substances chimiques
Epitopes
0
HLA-B Antigens
0
Receptors, Antigen, T-Cell
0
Tumor Necrosis Factor Inhibitors
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2731-2736Informations de copyright
© 2023. The Author(s).
Références
Benjamin, R. & Parham, P. Guilt by association: HLA-B27 and ankylosing spondylitis. Immunol. Today 11, 137–142 (1990).
doi: 10.1016/0167-5699(90)90051-A
pubmed: 2187471
Faham, M. et al. Discovery of T cell receptor beta motifs specific to HLA-B27-positive ankylosing spondylitis by deep repertoire sequence analysis. Arthritis Rheumatol. 69, 774–784 (2017).
doi: 10.1002/art.40028
pubmed: 28002888
Komech, E. A. et al. CD8+ T cells with characteristic T cell receptor beta motif are detected in blood and expanded in synovial fluid of ankylosing spondylitis patients. Rheumatology 57, 1097–1104 (2018).
doi: 10.1093/rheumatology/kex517
pubmed: 29481668
Pogorelyy, M. V. et al. Detecting T cell receptors involved in immune responses from single repertoire snapshots. PLoS Biol. 17, e3000314 (2019).
doi: 10.1371/journal.pbio.3000314
pubmed: 31194732
pmcid: 6592544
May, E. et al. Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen. Tissue Antigens 60, 299–308 (2002).
doi: 10.1034/j.1399-0039.2002.600404.x
pubmed: 12472659
Yang, X. et al. Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature 612, 771–777 (2022).
doi: 10.1038/s41586-022-05501-7
pubmed: 36477533
pmcid: 10511244
Komech, E. A. et al. TCR repertoire profiling revealed antigen-driven CD8+ T cell clonal groups shared in synovial fluid of patients with spondyloarthritis. Front. Immunol. 13, 973243 (2022).
doi: 10.3389/fimmu.2022.973243
pubmed: 36325356
pmcid: 9618624
Garrido-Mesa, J. & Brown, M. A. T cell repertoire profiling and the mechanism by which HLA-B27 causes ankylosing spondylitis. Curr. Rheumatol. Rep. 24, 398–410 (2022).
doi: 10.1007/s11926-022-01090-6
pubmed: 36197645
pmcid: 9666335
Bowness, P. HLA-B27. Annu. Rev. Immunol. 33, 29–48 (2015).
doi: 10.1146/annurev-immunol-032414-112110
pubmed: 25861975
Chiocchia, G., Boissier, M. C. & Fournier, C. Therapy against murine collagen-induced arthritis with T cell receptor V beta-specific antibodies. Eur. J. Immunol. 21, 2899–2905 (1991).
doi: 10.1002/eji.1830211202
pubmed: 1836185
Liu, Z. et al. Prevention of type 1 diabetes in the rat with an allele-specific anti-T-cell receptor antibody: Vbeta13 as a therapeutic target and biomarker. Diabetes 61, 1160–1168 (2012).
doi: 10.2337/db11-0867
pubmed: 22368175
pmcid: 3331757
Paul, S. et al. TCR beta chain-directed bispecific antibodies for the treatment of T cell cancers. Sci. Transl. Med. 13, eabd3595 (2021).
doi: 10.1126/scitranslmed.abd3595
pubmed: 33649188
pmcid: 8236299
Maciocia, P. M. et al. Targeting the T cell receptor beta-chain constant region for immunotherapy of T cell malignancies. Nat. Med. 23, 1416–1423 (2017).
doi: 10.1038/nm.4444
pubmed: 29131157
Putintseva, E. V. et al. Mother and child T cell receptor repertoires: deep profiling study. Front. Immunol. 4, 463 (2013).
doi: 10.3389/fimmu.2013.00463
pubmed: 24400004
pmcid: 3872299
Xue, Z. et al. Disease associated human TCR characterization by deep-learning framework TCR-DeepInsight. Preprint at bioRxiv https://doi.org/10.1101/2023.05.22.541406 (2023).
Nakayama, M. & Michels, A. W. Using the T cell receptor as a biomarker in type 1 diabetes. Front. Immunol. 12, 777788 (2021).
doi: 10.3389/fimmu.2021.777788
pubmed: 34868047
pmcid: 8635517
Rosati, E. et al. A novel unconventional T cell population enriched in Crohn’s disease. Gut 71, 2194–2204 (2022).
doi: 10.1136/gutjnl-2021-325373
pubmed: 35264446
Valente, D. et al. Pharmacokinetics of novel Fc-engineered monoclonal and multispecific antibodies in cynomolgus monkeys and humanized FcRn transgenic mouse models. mAbs 12, 1829337 (2020).
doi: 10.1080/19420862.2020.1829337
pubmed: 33079615
pmcid: 7587234
Mamedov, I. Z. et al. Quantitative tracking of T cell clones after haematopoietic stem cell transplantation. EMBO Mol. Med. 3, 201–207 (2011).
doi: 10.1002/emmm.201100129
pubmed: 21374820
pmcid: 3377069
Britanova, O. V. et al. First autologous hematopoietic SCT for ankylosing spondylitis: a case report and clues to understanding the therapy. Bone Marrow Transpl. 47, 1479–1481 (2012).
doi: 10.1038/bmt.2012.44
Hayashi, F. et al. A new clustering method identifies multiple sclerosis-specific T-cell receptors. Ann. Clin. Transl. Neurol. 8, 163–176 (2021).
doi: 10.1002/acn3.51264
pubmed: 33400858
pmcid: 7818280
Sewell, A. K. Why must T cells be cross-reactive? Nat. Rev. Immunol. 12, 669–677 (2012).
doi: 10.1038/nri3279
pubmed: 22918468
pmcid: 7097784
Montalvao, F. et al. The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging. J. Clin. Invest. 123, 5098–5103 (2013).
doi: 10.1172/JCI70972
pubmed: 24177426
pmcid: 3859399
Shugay, M. et al. Towards error-free profiling of immune repertoires. Nat. Methods 11, 653–655 (2014).
doi: 10.1038/nmeth.2960
pubmed: 24793455
Bolotin, D. A. et al. MiXCR: software for comprehensive adaptive immunity profiling. Nat. Methods 12, 380–381 (2015).
doi: 10.1038/nmeth.3364
pubmed: 25924071
Shugay, M. et al. VDJtools: unifying post-analysis of T cell receptor repertoires. PLoS Comput. Biol. 11, e1004503 (2015).
doi: 10.1371/journal.pcbi.1004503
pubmed: 26606115
pmcid: 4659587
Wickham, H. ggplot2: Elegant Graphics for Data Analysis 1st edn (Springer-Verlag, 2009).
doi: 10.1007/978-0-387-98141-3
Wagih, O. ggseqlogo: a versatile R package for drawing sequence logos. Bioinformatics 33, 3645–3647 (2017).
doi: 10.1093/bioinformatics/btx469
pubmed: 29036507