Stromal cells regulate mechanics of tumour spheroid.
Cancer spheroids
Contractility
Mechanobiology
Stromal cells
Traction forces
Journal
Materials today. Bio
ISSN: 2590-0064
Titre abrégé: Mater Today Bio
Pays: England
ID NLM: 101757228
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
04
05
2023
revised:
15
09
2023
accepted:
24
09
2023
medline:
23
10
2023
pubmed:
23
10
2023
entrez:
23
10
2023
Statut:
epublish
Résumé
The remarkable contractility and force generation ability exhibited by cancer cells empower them to overcome the resistance and steric hindrance presented by a three-dimensional, interconnected matrix. Cancer cells disseminate by actively remodelling and deforming their extracellular matrix (ECM). The process of tumour growth and its ECM remodelling have been extensively studied, but the effect of the cellular tumour microenvironment (TME) has been ignored in most studies that investigated tumour-cell-mediated ECM deformations and realignment. This study reports the integration of stromal cells in spheroid contractility assays that impacts the ECM remodelling and invasion abilities of cancer spheroids. To investigate this, we developed a novel multilayer
Identifiants
pubmed: 37868949
doi: 10.1016/j.mtbio.2023.100821
pii: S2590-0064(23)00281-8
pmc: PMC10585335
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100821Informations de copyright
Crown Copyright © 2023 Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Trends Cancer. 2022 Aug;8(8):683-697
pubmed: 35568647
Front Bioeng Biotechnol. 2020 Apr 21;8:198
pubmed: 32373594
Cancer Res. 2019 Jun 15;79(12):3011-3027
pubmed: 31053634
Science. 2020 Oct 30;370(6516):
pubmed: 33122355
Nat Cell Biol. 2017 Mar;19(3):224-237
pubmed: 28218910
Nat Rev Immunol. 2015 Nov;15(11):669-82
pubmed: 26471778
Nat Commun. 2021 Apr 12;12(1):2168
pubmed: 33846322
Cancers (Basel). 2022 Jun 27;14(13):
pubmed: 35804913
Biophys J. 2013 Nov 5;105(9):1967-75
pubmed: 24209841
Methods Mol Biol. 2017;1627:429-451
pubmed: 28836218
Med Eng Phys. 2016 Sep;38(9):854-61
pubmed: 27349492
Nat Commun. 2017 Oct 13;8(1):924
pubmed: 29030636
J Biomech Eng. 2017 Feb 1;139(2):
pubmed: 27814431
PLoS One. 2012;7(2):e32572
pubmed: 22389710
Biofabrication. 2023 Jun 06;15(3):
pubmed: 37201517
Immunity. 2019 Jul 16;51(1):27-41
pubmed: 31315034
Bioeng Transl Med. 2022 Nov 17;8(2):e10454
pubmed: 36925684
Cell Death Dis. 2022 May 20;13(5):478
pubmed: 35589690
Biophys J. 2014 Dec 2;107(11):2546-58
pubmed: 25468334
PLoS One. 2016 Jun 07;11(6):e0156442
pubmed: 27271249
Biochim Biophys Acta Mol Cell Res. 2021 Oct;1868(11):119103
pubmed: 34293346
J Vis Exp. 2011 Nov 16;(57):
pubmed: 22126971
Elife. 2020 Apr 30;9:
pubmed: 32352379
Nat Rev Cancer. 2020 Mar;20(3):174-186
pubmed: 31980749
Commun Phys. 2021 Nov 4;4:237
pubmed: 34841089
Front Oncol. 2021 Jul 07;11:692142
pubmed: 34307156
Sci Adv. 2023 Aug 11;9(32):eadg9781
pubmed: 37566656
Cancer Res. 2008 Sep 15;68(18):7247-9
pubmed: 18794108
Extreme Mech Lett. 2018 May;21:25-34
pubmed: 30135864
Front Aging Neurosci. 2023 Jul 20;15:1212212
pubmed: 37547743
Adv Sci (Weinh). 2023 Jun;10(16):e2206554
pubmed: 37051804
Biotechnol Bioeng. 2019 Jan;116(1):206-226
pubmed: 30367820
Nano Lett. 2019 Jul 10;19(7):4427-4434
pubmed: 31199151
Comput Struct Biotechnol J. 2018 Jul 27;16:279-287
pubmed: 30128085
Oncol Lett. 2022 Jan;23(1):26
pubmed: 34868363
Front Immunol. 2019 Apr 12;10:757
pubmed: 31031757
Transl Oncol. 2021 Jan;14(1):100899
pubmed: 33080522
Acta Biomater. 2019 Jan 15;84:280-292
pubmed: 30500449